Type 2 Diabetes Mellitus in Children

Ludwig, David S.; Ebbeling, Cara B.

doi:10.1001/jama.286.12.1427

Cited by 140 publications

(24 citation statements)

References 34 publications

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“…This is a trend similar to that seen in Western countries [3]- [5]. However, the prevention of childhood obesity remains a priority because obesity is associated with cardiovascular [6] [7], endocrine [8] [9], and respiratory diseases [10] among children. Furthermore, high body mass in infancy or early childhood is likely to persist into adulthood [11]- [13].…”

Section: Introductionsupporting

confidence: 61%

Child Care Providers’ Perceptions of Children’s Lifestyles and Risk Factors for Obesity: A Focus Group Study

Haga¹,

Takagi²,

Nakagomi³

2014

Health

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Objective: This study attempts to understand child care providers' perceptions of remarkable children's lifestyles and discusses potentially successful strategies of cooperation among child care providers, parents, and health professionals for health promotion and the prevention of obesity in preschool children. Methods: We conducted 6 focus group discussions consisting of 34 child care providers employed by private and public child care centers, and a public kindergarten in Yamanashi Prefecture, Japan. Systematic thematic analysis was conducted to generate themes to address the study questions. Results: What the focus group participants discussed with felt mainly into the 3 different kinds of points: "Concerns of Child Care Providers Regarding Parental Attitudes about Nutrition and Nurture," "Tensions between Parents and Child Care Providers," and "Current Obesity Prevention Activities and the Role of Child Care Professionals." Conclusions: Childcare providers had many concerns that fell into 5 main issues of the possible detrimental effects on children's health due to parents' nurturing methods and lifestyles. Participants described possible strategies for the prevention of childhood obesity in childcare settings as well as barriers to effective intervention. Childcare providers felt that a system to demand helps from public health nurses in guiding parents would be effective in preventing childhood obesity.

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Section: Introductionsupporting

confidence: 61%

Child Care Providers’ Perceptions of Children’s Lifestyles and Risk Factors for Obesity: A Focus Group Study

Haga¹,

Takagi²,

Nakagomi³

2014

Health

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“…[1][2][3] Type 2 diabetes mellitus accounts for 33% to 46% of all diagnosed cases of diabetes mellitus in children and adolescents between the ages of 10 and 19 years. 4,5 The prevalence of type 2 diabetes mellitus in children and adolescents has been estimated between 2 and 50 cases per 1000 in various populations, representing a 10-fold increase during the past 2 decades. 4,5 Type 2 diabetes mellitus has been associated with multiple comorbidities, and children with multiple chronic conditions have had severe long-term consequences.…”

Section: Discussionmentioning

confidence: 99%

“…4,5 The prevalence of type 2 diabetes mellitus in children and adolescents has been estimated between 2 and 50 cases per 1000 in various populations, representing a 10-fold increase during the past 2 decades. 4,5 Type 2 diabetes mellitus has been associated with multiple comorbidities, and children with multiple chronic conditions have had severe long-term consequences. 6,7 Considering the future economic burden and the subsequent loss of productivity as adults because of premature morbidity, type 2 diabetes mellitus in children is considered a major public health problem in the United States.…”

Section: Discussionmentioning

confidence: 99%

Pediatricians' Perceptions and Practices Regarding Prevention and Treatment of Type 2 Diabetes Mellitus in Children and Adolescents

Ditmyer

Price²,

Telljohann³

et al. 2003

Arch Pediatr Adolesc Med

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Pediatricians who had a higher perceived confidence level and who perceived they were better prepared for the counseling and follow-up of patients with type 2 diabetes mellitus had a greater potential to positively affect their diabetic patients. Improving continuing medical education and residency-based programs is imperative to adequately address the emerging epidemic of type 2 diabetes mellitus in children and adolescents.

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“…The burden of diabetes is assuming pandemic proportions [1], with an increasingly worrying incidence among children [2]. It has been known for some time that dietary factors can influence the risk of insulin resistance, and in recent years it has come to light that this risk can be transmitted to offspring through intrauterine reprogramming events.…”

Section: Introductionmentioning

confidence: 99%

In utero Exposure to Germinated Brown Rice and Its GABA Extract Attenuates High-Fat-Diet-Induced Insulin Resistance in Rat Offspring

Adamu

Imam²,

Ooi³

et al. 2017

Lifestyle Genomics

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Background: Numerous studies have reported on the influence of diet on insulin resistance. Our study provides insight into the effect of germinated brown rice (GBR) and γ-aminobutyric acid (GABA) on early environment-driven programming and susceptibility to insulin resistance in rat offspring. Methods: Male rat offspring from female Sprague-Dawley rats fed with a high-fat diet (HFD) alone, HFD + GBR, or HFD + GABA extract throughout pregnancy and lactation were weaned 4 weeks after delivery and followed up for 8 weeks. A biochemical analysis and an assessment of the hepatic expression of insulin signaling genes were performed. Results: The results showed that intrauterine exposure to HFD caused metabolic perturbations in rat offspring which gravitated towards insulin resistance even though the rat offspring did not consume an HFD. GBR and GABA attenuated the HFD-induced changes by underlying regulation of the insulin signaling genes. Conclusions: The results suggest that intake of GBR and GABA during pregnancy and lactation can influence the programming of genes in rat offspring, thereby enhancing insulin sensitivity.

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Type 2 Diabetes Mellitus in Children

Cited by 140 publications

References 34 publications

Child Care Providers’ Perceptions of Children’s Lifestyles and Risk Factors for Obesity: A Focus Group Study

Child Care Providers’ Perceptions of Children’s Lifestyles and Risk Factors for Obesity: A Focus Group Study

Pediatricians' Perceptions and Practices Regarding Prevention and Treatment of Type 2 Diabetes Mellitus in Children and Adolescents

In utero Exposure to Germinated Brown Rice and Its GABA Extract Attenuates High-Fat-Diet-Induced Insulin Resistance in Rat Offspring

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