Type-2 Diabetes Mellitus and Oral Tumors in Hungary: A Long-term Comparative Epidemiological Study

Abstract

Diabetes is considered an endemic medical condition with increasing prevalence globally. This tendency has been also detected in Hungary where the prevalence of diabetes among the adult population reached 7% according to the latest statistical data (1). Numerous data from several medical publications have shown that diabetes is a promoting factor in the formation of malignant tumors at different sites and has a negative impact on tumor progression and patient survival (2-16). Our medical research team has long studied the correlations between oral cavity cancer and diabetes, mainly type 2 diabetes (17, 18). Since type-2 diabetes has rapidly increased in prevalence globally and the morbidity and mortality rates of oral cavity cancer -especially in Hungary-do not show any significant decrease, we examined the relationship between glucose metabolic disorders and oral cancer in our clinic over the past 14 years. In the present study, we analyzed data of 758 patients with oral cavity cancer and 534 tumor-free control patients and examined the prevalence of diabetes and impaired fasting glucose (IFG), the distribution of tumor location and the role of smoking. Additionally, we compared our current results to data obtained 14 years ago. Patients and MethodsWe conducted a retrospective research study in the inpatient ward of the Semmelweis University Department of Oral and Maxillofacial Surgery, Budapest, Hungary. We examined patients who were diagnosed with histologically confirmed malignant oral tumors. The examination period was between the 1st of January, 2012 and 31st of December, 2015. These results were compared to an earlier study that was conducted in the same Department between the 1st of January, 1998 and 30th of June, 2002. We processed the data of 610 patients (435 males and 175 females) in the first interval and the data of 758 patients (400 male and 358 female) in the second interval. All patients were diagnosed with histologically confirmed malignant cancer. Based on these histological data, we confirmed that 606 cases among the 610 and 749 cases among the 758 were squamous cell carcinomas, while the remainder consisted of adenocarcinomas. The average age of the patients from the previous study was 56 years (range=36-85), whereas the average age of the patients in the follow-up study was 64 years (range=12-92).The control group in the first research interval was formed by 574 patients (351 male, 223 female). Their average age was 51 years (range=32-79).The control group in the second study interval was formed by 534 patients (318 male, 216 female) with an average age of 53 years (range=30-94). The patients of the control group in both study intervals volunteered for stomato-oncological screening and found symptom-and cancer-free.We considered patients with diabetes mellitus (DM) to be those who had been previously diagnosed and treated for diabetes by an internist or diabetologist. We classified patients into the IFG group when their fasting blood glucose values were between 6.1 and 6.9 mmol/l. We cons...

Body Mass Index and Diabetes Mellitus May Predict Poorer Overall Survival of Oral Squamous Cell Carcinoma Patients: A Retrospective Cohort From a Tertiary-Care Centre of a Resource-Limited Country

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Point-of-care HbA1c Measurements in Oral Cancer and Control Patients in Hungary

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