2017
DOI: 10.1161/strokeaha.117.017709
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Type 2 Diabetes Mellitus and Impaired Renal Function Are Associated With Brain Alterations and Poststroke Cognitive Decline

Abstract: URL: http://www.clinicaltrials.gov. Unique identifier: NCT01926691.

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Cited by 51 publications
(49 citation statements)
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“…The third independent variable associated with WMH progression was GFR, with lower GFR values in WHM progressors. The finding that patients with impaired renal function have an increased WMH burden has been reported in several cross-sectional studies both in subjects with cardiovascular risk factors [35,36], and patients with previous stroke [37,38]. Nevertheless, this is the first longitudinal study in patients with a carotid plaque showing a significant association between renal impairment and risk of WMH progression.…”
Section: Discussionsupporting
confidence: 50%
“…The third independent variable associated with WMH progression was GFR, with lower GFR values in WHM progressors. The finding that patients with impaired renal function have an increased WMH burden has been reported in several cross-sectional studies both in subjects with cardiovascular risk factors [35,36], and patients with previous stroke [37,38]. Nevertheless, this is the first longitudinal study in patients with a carotid plaque showing a significant association between renal impairment and risk of WMH progression.…”
Section: Discussionsupporting
confidence: 50%
“…This model also did not exacerbate white matter injury after stroke. The disruption of white matter integrity in the uninjured brain of T2D patients has been recently shown [59]. However, whether it is exacerbated after stroke in T2D patients is still largely undetermined [60,61].…”
Section: Discussionmentioning
confidence: 99%
“…Interestingly, the Tel Aviv Brain Acute Stroke Cohort (TABASCO) study examined a combination of genetic, inflammatory, imaging, and psychological markers during the acute phase to predict longterm cognitive and functional decline, with collection of both blood and saliva [61]. While TABASCO identified imaging abnormalities, motor function (i.e., balance, gait), and comorbidities as biomarkers for cognitive decline [45,62,63], blood and saliva results have yet to be published.…”
Section: Current Biomarker Trials For Strokementioning
confidence: 99%