Type 2 diabetes and psoriasis: links and risks

Holm, Jesper Grønlund; Thomsen, Simon Francis

doi:10.2147/ptt.s159163

Cited by 27 publications

(31 citation statements)

References 47 publications

(66 reference statements)

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“…It is currently not known whether DD patients carry other risk factors for the development of diabetes irrespective of ATP2A2 mutation status. However, since some DD patients seem to lack ATP2A2 mutations altogether, speculations could be made as to the existence of possible diabetes risk factors other than mutation status per se for DD patients, for example skin inflammation, as inflammatory skin conditions such as psoriasis is linked with type 2 diabetes [9]. This is also in accordance to our data showing no significant difference between the pathogenic and benign mutation variants among DD patients ( Table 2).…”

Section: Table 1 Baseline Characteristics and Glucose Metabolismsupporting

confidence: 90%

Metabolic phenotype in Darier disease: a cross-sectional clinical study

Ahanian

Curman

Leong

et al. 2020

Diabetol Metab Syndr

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Background: Human data supporting a role for endoplasmic reticulum (ER) stress and calcium dyshomeostasis in diabetes is scarce. Darier disease (DD) is a hereditary skin disease caused by mutations in the ATP2A2 gene encoding the sarcoendoplasmic-reticulum ATPase 2 (SERCA2) calcium pump, which causes calcium dyshomeostasis and ER stress. We hypothesize that DD patients have a diabetes-like metabolic phenotype and the objective of this study was to examine the association between DD with impaired glucose tolerance and diabetes. Methods: Cross-sectional clinical study on 25 DD patients and 25 matched controls. Metabolic status was assessed primarily by fasting blood glucose, oral glucose tolerance test, HOMA2-%S (insulin resistence) and HOMA2-%B (beta cell function). Results: DD subjects showed normal oral glucose tolerance test and HOMA2-%S, while fasting blood glucose was lower and c-peptide as well as HOMA2-%B was higher. Conclusion: Increased HOMA2-%B values are indicative of increased basal insulin secretion which is a type of beta cell dysfunction associated to diabetes development. These results supports a role of ER stress in diabetes pathophysiology and contribute to the understanding of DD as a multi-organ syndrome.

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Section: Table 1 Baseline Characteristics and Glucose Metabolismsupporting

confidence: 90%

Metabolic phenotype in Darier disease: a cross-sectional clinical study

Ahanian

Curman

Leong

et al. 2020

Diabetol Metab Syndr

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“…A systematic review reported that the average prevalence of type 2 diabetes in psoriasis patients was 11.6% (15 epidemiologic cohorts evaluated) [39]. The same study showed an increased prevalence of type 2 diabetes in subjects with psoriasis compared with controls (11 studies evaluated).…”

Section: Diabetesmentioning

confidence: 97%

Psoriasis and Cardiovascular Risk: A Comprehensive Review

Masson

Lobo²,

Molinero³

2020

Adv Ther

117

129

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Psoriasis is a systemic inflammatory disorder that involves complex pathogenic interactions between the innate and adaptive immune systems. Individuals with psoriasis have an increased risk of developing other chronic health diseases such cardiovascular disorders. The high incidence of cardiovascular events in the population with psoriasis could be explained by several mechanisms. The high prevalence of traditional cardiovascular risk factors and metabolic abnormalities contributes to the high cardiovascular burden in patients with psoriasis. Likewise, the presence of systemic inflammation in combination with metabolic abnormalities may act in a synergistic manner to increase cardiovascular risk in these patients. This review focused on epidemiologic and clinical evidence linking psoriasis to cardiovascular risk factors and cardiovascular disease. We described the possible pathophysiological mechanisms that justify this association and analyzed the best way to stratify the cardiovascular risk in patients with psoriasis. We also described the usefulness of the therapies frequently used in cardiovascular prevention and analyzed the impact of the specific psoriasis medication on cardiovascular risk factors or major atherosclerotic events. Knowledge of the application of different cardiovascular prevention strategies could mean an advantage in performing the difficult task of estimating cardiovascular risk and treating cardiovascular risk factors in this particular group of patients.

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“…Patients with psoriasis have a significantly higher risk of type 2 DM. However, the prevalence of type 2 DM does not correlate with patient age or severity of psoriasis [124]. Psoriasis is a marker for increased risk of type 2 DM independent of its severity.…”

Section: Intrinsic Risk Factorsmentioning

confidence: 99%

“…Psoriasis is a marker for increased risk of type 2 DM independent of its severity. It is unclear which disease comes first, psoriasis or type 2 DM [124]. As mentioned above, obesity is a risk factor for psoriasis.…”

Section: Intrinsic Risk Factorsmentioning

confidence: 99%

Risk Factors for the Development of Psoriasis

Kamiya

Kishimoto

Sugai

et al. 2019

IJMS

387

306

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Psoriasis is an immune-mediated genetic skin disease. The underlying pathomechanisms involve complex interaction between the innate and adaptive immune system. T cells interact with dendritic cells, macrophages, and keratinocytes, which can be mediated by their secreted cytokines. In the past decade, biologics targeting tumor necrosis factor-α, interleukin (IL)-23, and IL-17 have been developed and approved for the treatment of psoriasis. These biologics have dramatically changed the treatment and management of psoriasis. In contrast, various triggering factors can elicit the disease in genetically predisposed individuals. Recent studies suggest that the exacerbation of psoriasis can lead to systemic inflammation and cardiovascular comorbidity. In addition, psoriasis may be associated with other auto-inflammatory and auto-immune diseases. In this review, we summarize the risk factors, which can be divided into two groups (namely, extrinsic and intrinsic risk factors), responsible for the onset and exacerbation of psoriasis in order to facilitate its prevention.

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Type 2 diabetes and psoriasis: links and risks

Cited by 27 publications

References 47 publications

Metabolic phenotype in Darier disease: a cross-sectional clinical study

Metabolic phenotype in Darier disease: a cross-sectional clinical study

Psoriasis and Cardiovascular Risk: A Comprehensive Review

Risk Factors for the Development of Psoriasis

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