Type 2 diabetes and osteoarthritis: a systematic review and meta-analysis

Williams, Mia; London, Daniel A.; Husni, M. Elaine; Navaneethan, Sankar D.; Kashyap, Sangeeta R.

doi:10.1016/j.jdiacomp.2016.02.016

Cited by 134 publications

(118 citation statements)

References 26 publications

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“…In the last years, large interest is growing to define the relationship between OA and hyperglycemia and/or impaired glucose tolerance (IGT) (Williams et al, ). Many studies showed a positive correlation between blood glucose levels and KOA (Cimmino and Cutolo, ; Schett et al, ), while others found no association between these two conditions (Anderson and Felson, ; Frey et al, ).…”

Section: Obesity and Related Comorbidities In Koamentioning

confidence: 99%

Systemic and Local Adipose Tissue in Knee Osteoarthritis

Belluzzi

Hadi

Granzotto

et al. 2017

Journal Cellular Physiology

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Osteoarthritis is a common chronic joint disorder affecting older people. The knee is the major joint affected. The symptoms of osteoarthritis include limited range of motion, joint swelling, and pain causing disability. There are no disease modifying drugs available, and treatments are mainly focused on pain management. Total knee replacement performed at the end stage of the disease is considered the only cure available. It has been found that obese people have an increased risk to develop not only knee but also hand osteoarthritis. This supports the concept that adipose tissue might be related to osteoarthritis not only through overloading. As matter of fact, obesity induces a low grade systemic inflammatory state characterized by the production and secretion of several adipocytokines that may have a role in osteoarthritis development. Furthermore, hypertension, impaired glucose, and lipid metabolism, which are comorbidities associated with obesity, have been shown to alter the joint tissue homeostasis. Moreover, infrapatellar fat pad in the knee has been demonstrated to be a local source of adipocytokines and potentially contribute to osteoarthritis pathogenesis. Here, we discuss the role of systemic and local adipose tissue in knee osteoarthritis. J. Cell. Physiol. 232: 1971-1978, 2017. © 2016 Wiley Periodicals, Inc.

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Section: Obesity and Related Comorbidities In Koamentioning

confidence: 99%

Systemic and Local Adipose Tissue in Knee Osteoarthritis

Belluzzi

Hadi

Granzotto

et al. 2017

Journal Cellular Physiology

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“…Davies-Tuck ML et al [24] reported the evidence that increased FG concentration in a non-diabetic individuals was associated with adverse structural changes at the knee in women based on one prospective cohort study. William MF et al [25] executed one meta-analysis including ten observational studies with 16,742 patients in total. They revealed that T2D was associated with radiographic and symptomatic OA even after controlling the BMI and weight.…”

Section: Discussionmentioning

confidence: 99%

Type 2 diabetes and glycemic traits are not causal factors of osteoarthritis: A two-sample Mendelian randomization analysis

Cui

Feng

et al. 2020

Preprint

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Background: It remains unclear whether an increased risk of type 2 diabetes (T2D) affects the risk of osteoarthritis (OA). Methods: Here, we used two-sample Mendelian randomization (MR) to obtain non-confounded estimates of the effect of T2D and glycemic traits on hip and knee OA. We identified single nucleotide polymorphisms (SNPs) strongly associated with T2D, fasting glucose (FG) and 2-hour postprandial glucose (2hGlu) from genome-wide association studies (GWAS) . We used MR inverse variance weighted (IVW), the MR-Egger method, the weighted median (WM) and Robust Adjusted Profile Score (MR.RAPS) to reveal the associations of T2D, FG and 2hGlu with hip and knee OA risk. Sensitivity analyses were also conducted to verify whether heterogeneity and pleiotropy can bias the MR results.Results: We did not find statistically significant causal effects of genetically increased T2D risk, FG and 2hGlu on hip and knee OA (e.g., T2D and hip OA, MR-Egger OR=0.9536, 95% CI 0.5585 to 1.6283, p=0.8629). It was confirmed that horizontal pleiotropy was unlikely to bias the causality (e.g., T2D and hip OA, MR-Egger, intercept=-0.0032, p=0.8518). No evidence of heterogeneity was found between the genetic variants (e.g., T2D and hip OA, MR-Egger Q=40.5481, I2=0.1368, p=0.2389). Conclusions: Our MR study did not support causal effects of a genetically increased T2D risk, FG and 2hGlu on hip and knee OA risk.

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“…The lack of associations of diabetic and cholesterol medication use with incident ROA may have resulted from confounding by indication. Therefore, it is still possible that hyperlipidemia[41–43] and diabetes[44] are risk factors for incident ROA. There is the potential that targeting hyperlipidemia and diabetes, other components of metabolic syndrome, might be helpful in preventing incident OA, important questions to address in future research.…”

Section: Discussionmentioning

confidence: 99%

Systolic and pulse pressure associate with incident knee osteoarthritis: data from the Osteoarthritis Initiative

McAlindon

Katz

et al. 2017

Clin Rheumatol

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Objectives We evaluated the relationship of systolic blood pressure, diastolic blood pressure, pulse pressure, and treatment with antihypertensives with knee osteoarthritis incidence in a United States cohort. Methods We performed a longitudinal study (2004 – 2010) nested within the Osteoarthritis Initiative Study including only individuals without knee osteoarthritis at baseline. Systolic blood pressure, diastolic blood pressure and pulse pressure were assessed at baseline, 12-, 24-, and 36-month visits. Knee radiographs at baseline, 12-, 24-, 36- and 48 month visits defined radiographic osteoarthritis, Kellgren and Lawrence grade ≥ 2. We performed logistic regression, adjusting for age, sex, body mass index, NSAID use, number of antihypertensive medications, diabetic medications, and cholesterol medications. Results 1930 people (6040 observations) were included. Annual incidence rates of radiographic osteoarthritis by systolic blood pressure quartiles (lowest to highest) were 2.1%, 3.4%, 3.7%, and 3.7%. Fully adjusted odds ratios of incident radiographic OA for the 2nd–4th quartiles were 1.6, 1.7, and 1.6 relative to the lowest quartile (p for trend = 0.03). Pulse pressure results were similar. There was no association with diastolic blood pressure. Compared to those not taking any antihypertensive medications, those taking ≥ 3 had decreased odds (0.4, 0.1–1.0) of developing incident OA. Conclusions In a United States cohort, higher systolic blood pressure and pulse pressure are associated with increased incidence of radiographic knee osteoarthritis while treatment with ≥ 3 antihypertensive medications was associated with reduced incidence. These findings suggest a new and promising avenue for research on disease modification in knee osteoarthritis.

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Type 2 diabetes and osteoarthritis: a systematic review and meta-analysis

Cited by 134 publications

References 26 publications

Systemic and Local Adipose Tissue in Knee Osteoarthritis

Systemic and Local Adipose Tissue in Knee Osteoarthritis

Type 2 diabetes and glycemic traits are not causal factors of osteoarthritis: A two-sample Mendelian randomization analysis

Systolic and pulse pressure associate with incident knee osteoarthritis: data from the Osteoarthritis Initiative

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