Type 2 diabetes and hepatocellular carcinoma: A case–control study in patients with chronic hepatitis B

Li, Qiang; Li, Wenwen; Yang, Xia; Fan, Wenbo; Jin-hong, YU; Xie, Shuangshuang; Liu, Li; Ma, Liang; Chen, Shijun; Kato, Naoya

doi:10.1002/ijc.27337

Cited by 41 publications

(70 citation statements)

References 33 publications

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“…DM co-coexists with HBV infection, male gender, and age in HCC development, suggesting the potential synergism among these risk factors in driving HCC. The data is consistent with the previous studies with the populations in US [9][10], Europe [7], and Asian [8,11]. Our study suggested that DM is a risk factor of HCC that may work independently or synergistically with other risk factors.…”

Section: Discussionsupporting

confidence: 93%

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Diabetes Mellitus Is Associated with Hepatocellular Carcinoma: A Retrospective Study in Southwest China

Tang¹,

Wu²,

Cui³

2017

Hematol Med Oncol

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Background and aims: A lot of case-control patient studies have investigated the association between diabetes mellitus (DM) and hepatocellular carcinoma (HCC). Despite some controversial reports, it has been suggested that DM is associated with HCC. Therefore, it is necessary to delineate the involvement of DM, together with other related risk factors, in HCC with large sample size and strict analysis methodology.

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Section: Discussionsupporting

confidence: 93%

“…Increasing evidence has suggested the association between DM and HCC in different populations [6][7][8]. In our study, both unadjusted logistic regression and stepwise logistic regression analysis indicated a strong and statistically significant association between DM and HCC in Chongqing population where hepatitis is endemic.…”

Section: Discussionsupporting

confidence: 55%

Diabetes Mellitus Is Associated with Hepatocellular Carcinoma: A Retrospective Study in Southwest China

Tang¹,

Wu²,

Cui³

2017

Hematol Med Oncol

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show abstract

“…The values of odds ratio were trivially smaller (OR=14.05, OR=4.61, OR=3.08, and OR=2.35, respectively) than those in unadjusted model. The strong association between DM and HCC is consistent with cohort and case-control studies with the populations in US, Europe, and other Asian populations [9] [10-12] [13-16]. …”

Section: Resultssupporting

confidence: 82%

“…Increasing evidence has suggested the association between DM and HCC in different populations [9,10,13]. In our case-control study, both unadjusted logistic regression and stepwise logistic regression analysis indicated a strong and statistically significant association between DM and HCC in Chinese population where hepatitis is endemic.…”

Section: Discussionsupporting

confidence: 53%

Diabetes Mellitus Is Associated with Hepatocellular Carcinoma: A Retrospective Case-Control Study in Hepatitis Endemic Area

et al. 2013

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BackgroundA number of case-control patient studies have been conducted to investigate the association between diabetes mellitus (DM) and hepatocellular carcinoma (HCC). Despite some controversial reports, it has been suggested that DM is associated with HCC. The previous studies on this subject vary in the selection of populations, sample sizes, methodology, and analysis results. Therefore, it is necessary to further delineate the involvement of DM, together with other related risk factors, in HCC with large sample size and strict analysis methodology.MethodsWe conducted a hospital-based retrospective case-control study at Perking Union Medical College Hospital, China. A total of 1,568 patients with liver diseases were enrolled in the statistical study to evaluate the association of DM and other risk factors with HCC. Among these patients, 716 of them were diagnosed with benign liver diseases, and 852 patients were diagnosed as HCC. We utilized binary logistic regression and stepwise logistic regression to investigate the associations among DM, hypertension, fatty liver, cirrhosis, gallstone, HBV infection, HCV infection, and HCC. ResultsStatistical analysis through the stepwise regression model indicated that the prevalence of DM, male gender, cirrhosis, HCV infection, or HBV infection is higher in the HCC patient group compared to the control group. However, the prevalence of gallstone is negatively associated with HCC cases. DM co-exists with HBV infection, male gender, and age in the HCC cases. Binary logistic regression analysis suggested that DM may synergize with HBV infection in HCC development. ConclusionDM is strongly associated with the increased risk of HCC regardless of the prevalence of HBV infection, HCV infection, cirrhosis, male gender, and age. However, the synergistic interaction between DM and HBV in HCC occurrence is significant. Therefore, DM patients with HBV infection represent a very high HCC risk population and should be considered for HCC close surveillance program.

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“…The details of information collection and laboratory measurements were previously described [19,20]. The transmission routes and risk factors of HBV infection were recorded using a structured questionnaire.…”

Section: Methodsmentioning

confidence: 99%

Clinical features and outcome of acute hepatitis B in pregnancy

et al. 2014

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BackgroundThe impact of pregnancy on the clinical course of acute hepatitis B (AHB) is still largely unclear, mainly because most studies have not included matched controls. This study was conducted to investigate the clinical features and outcome of AHB in pregnancy using matched controls.MethodsConsecutive AHB inpatients who were admitted to Jinan Infectious Disease Hospital, Jinan, between January 2006 and December 2010 were evaluated and followed. Demographic data, clinical manifestations, and results of laboratory tests were compared between pregnant patients and age and sex matched non-pregnant patients at admission, discharge, and final follow-up.ResultsA total of 618 AHB inpatients were identified during the study period. 22 pregnant patients and 87 age and sex matched non-pregnant patients were enrolled in this study. Prodromal fever was less common (0% vs. 20.7%, P = 0.02), serum alanine aminotransferase levels were significantly lower, and HBsAg > 250 IU/mL rate and serum bilirubin levels were significantly higher in pregnant patients than in non-pregnant patients. After a mean (range) of 7(5.2-8.3) months follow-up, 18.2% pregnant patients and 4.6% non-pregnant patients were still HBsAg positive (P = 0.03). For pregnant patients, the relative risk (95% confidence interval) of HBsAg positive at the end of follow-up was 4.6 (1.1-20.2). The median (95% confidence interval) days of HBsAg seroclearance form disease onset in pregnant and non-pregnant patients were 145.0 (110.5-179.5) and 80.0 (62.6-97.4), respectively.ConclusionsThe HBsAg loss and seroconversion were delayed and lower in pregnant patients. Pregnancy might be a possible risk of chronicity following acute HBV infection.

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Type 2 diabetes and hepatocellular carcinoma: A case–control study in patients with chronic hepatitis B

Cited by 41 publications

References 33 publications

Diabetes Mellitus Is Associated with Hepatocellular Carcinoma: A Retrospective Study in Southwest China

Diabetes Mellitus Is Associated with Hepatocellular Carcinoma: A Retrospective Study in Southwest China

Diabetes Mellitus Is Associated with Hepatocellular Carcinoma: A Retrospective Case-Control Study in Hepatitis Endemic Area

Clinical features and outcome of acute hepatitis B in pregnancy

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