Type 2 Diabetes 2021–Beyond Glucose

Brunton,

doi:10.12788/jfp.0104

Cited by 9 publications

(18 citation statements)

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“…Como compensación, las células β secretan aún más insulina, logrando disminuir los niveles de glucosa circulante. Eventualmente las células se agotan y empiezan a funcionar de manera incorrecta, muriendo en el proceso y provocando la deficiencia de insulina y la hiperglucemia características de la diabetes mellitus tipo 2 (Brunton, 2016;Kahn et al, 2014).…”

Section: Patofisiologíaunclassified

Biomarcadores de la enfermedad de Alzheimer encontrados en pacientes con diabetes mellitus tipo 2: correlación entre ambas patologías

Walwyn-Hernández,

Cepeda-Morales,

Mateos-Platas

et al. 2023

AEBMedicine

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INTRODUCCIÓN: La diabetes mellitus tipo 2 es un problema serio de salud pública que afecta a alrededor de 462 millones de personas. Por otro lado, la enfermedad de Alzheimer es una enfermedad neurodegenerativa progresiva y el tipo de demencia más común. La evidencia sugiere que ambas patologías comparten ciertos mecanismos que pueden verse reflejados en biomarcadores de pacientes con ambas comorbilidades. OBJETIVOS: establecer una semejanza entre los principales biomarcadores encontrados en la enfermedad de Alzheimer con los biomarcadores encontrados en la diabetes mellitus tipo 2 que pudiera indicar una correlación entre ambas enfermedades. RESULTADOS: Los biomarcadores estándar utilizados para el diagnóstico de Alzheimer son Aβ42, Tτ y Pτ. Los niveles de proteína S100B sérica son influenciados por factores metabólicos implicados en la diabetes y se ven alterados en pacientes diabéticos que presentan Alzheimer. Se encontró que pacientes con dislipidemias que presentaban Alzheimer tenían deposiciones significativamente aumentadas de ERC-τ en comparación a pacientes exclusivamente con Alzheimer. De igual forma, se ha evidenciado que los factores IL-6 y TNF-α normalmente asociados a procesos inflamatorios característicos de la obesidad y diabetes mellitus tipo 2 participan en procesos de inflamación y neurodegenerativos del sistema nervioso central. Finalmente, la A2M y la APOE elevan el riesgo tanto de Alzheimer como de diabetes. CONCLUSIONES: Los marcadores séricos que presentan una posible correlación entre ambas enfermedades son ERC-τ, IL-6, TNF-α, A2M y APOE.

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Section: Patofisiologíaunclassified

Biomarcadores de la enfermedad de Alzheimer encontrados en pacientes con diabetes mellitus tipo 2: correlación entre ambas patologías

Walwyn-Hernández,

Cepeda-Morales,

Mateos-Platas

et al. 2023

AEBMedicine

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“…Type 2 diabetes mellitus (T2DM) is an ensemble of metabolic diseases that has reached pandemic dimensions all over the world. [1][2][3] Diabetes has reached pandemic dimensions, affecting over 400 million people worldwide, and it is also becoming relevant in developing countries. [4,5] Among the huge and heterogeneous number of patients with diabetes, T2DM represents the most prevalent form.…”

Section: Introductionmentioning

confidence: 99%

The effects of curcumin supplementation on high-sensitivity C-reactive protein, serum adiponectin, and lipid profile in patients with type 2 diabetes: A protocol for systematic review and meta-analysis

Sun

2022

Medicine

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Background: Type 2 diabetes mellitus (T2DM) is an ensemble of metabolic diseases that has reached pandemic dimensions all over the world. There is a lack of evidence on the contribution of curcumin in the treatment of T2DM. We conducted a protocol for systematic review and meta-analysis to evaluate whether curcumin supplementation is effective and safe in T2DM patients. Methods: The systematic review will follow the guidelines of Preferred Reporting Items for Systematic Reviews and Meta-analyses Protocols (PRISMA-P). We will obtain studies through PubMed, Cochrane Library, Embase, Web of Science, and Medline databases. In addition, we will also collect 4 databases of China: China National Knowledge Infrastructure, China Biomedical Literature Database, China Science Journal Database, and Wan-fang Database. Eligible study conference abstracts and reference lists of manuscripts will be searched. The data collection and analysis will be conducted independently by 2 reviewers. Meta-analysis will be performed using Review Manager software, version 5.3 (Update Software Ltd, Oxford, Oxon, UK). Results: The results of this systematic review and meta-analysis will be published in a peer-reviewed journal. Conclusion: The findings of this systematic review may encourage supplementation of curcumin and its preparation specifically in T2DM patients. Nevertheless, the application of curcumin supplementation in clinical practice should be taken with individual’s contributing factors.

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“…1 It is a group of chronic metabolic diseases characterized by high blood glucose that causes chronic damage and dysfunction in different tissues, especially the eyes, kidneys, heart, blood vessels and nerves. 2,3 Periodontitis is known as the sixth complication of diabetes. 4 Diabetes increases the risk and severity of periodontitis, but the specific mechanism remains unclear.…”

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confidence: 99%

Complement 3 mediates periodontal destruction in patients with type 2 diabetes by regulating macrophage polarization in periodontal tissues

Wang

et al. 2020

Cell Proliferation

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Type 2 diabetes (T2DM), also known as adult-onset diabetes, accounts for more than 90% of diabetic patients. 1 It is a group of chronic metabolic diseases characterized by high blood glucose that causes chronic damage and dysfunction in different tissues, especially the eyes, kidneys, heart, blood vessels and nerves. 2,3 Periodontitis is known as the sixth complication of diabetes. 4 Diabetes increases the risk and severity of periodontitis, but the specific mechanism remains unclear. 5-7

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Type 2 Diabetes 2021–Beyond Glucose

Cited by 9 publications

References 0 publications

Biomarcadores de la enfermedad de Alzheimer encontrados en pacientes con diabetes mellitus tipo 2: correlación entre ambas patologías

Biomarcadores de la enfermedad de Alzheimer encontrados en pacientes con diabetes mellitus tipo 2: correlación entre ambas patologías

The effects of curcumin supplementation on high-sensitivity C-reactive protein, serum adiponectin, and lipid profile in patients with type 2 diabetes: A protocol for systematic review and meta-analysis

Complement 3 mediates periodontal destruction in patients with type 2 diabetes by regulating macrophage polarization in periodontal tissues

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