Type 1 diabetes mellitus with ketoacidosis in infancy

Jali, M.V.; Patil, Vishwanath; Jali, Sujata; Gowda, Shivaraj; Kambar, Sanjay

doi:10.1007/s12098-009-0009-1

Cited by 5 publications

(4 citation statements)

References 7 publications

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“…Heavy metals, islet function and diabetes development Ya Wen Chen, 1, † Ching Yao Yang, 2, † Chun Fa Huang, 3 Dong Zong Hung, 4 Yuk Man Leung 5 and Shing Hwa Liu many kinds of the heavy metals accumulation in our organ tissue and inducing chronic toxicities. The studies that compared the levels of essential trace elements in biological samples of patients who have diabetes mellitus type 2, with those of nondiabetic control subjects, have suggested that deficiency and accumulation of some essential trace metals may play a role in the development of diabetes mellitus.…”

Section: Introductionmentioning

confidence: 99%

Heavy metals, islet function and diabetes development

Lin¹,

Yang²,

Huang³

et al. 2009

Islets

199

131

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Section: Introductionmentioning

confidence: 99%

Heavy metals, islet function and diabetes development

Lin¹,

Yang²,

Huang³

et al. 2009

Islets

199

131

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“…70 Family history is a major risk factor, and strong family history is reported to early age onset of T2DM and to also develop complications. 71 Studies from Kancheepuram district, Tamil Nadu, India, have also shown that 68.8% of the people affected with T2DM had a family history of diabetes and that 25.1% had a mother and 15.3% had father affected with the ailment, respectively, and that 51.6% had diabetic complications. 72 Together with all these observations indicate that the family history had a strong association with both ages of onset and complications.…”

Section: Discussionmentioning

confidence: 98%

“…72 Together with all these observations indicate that the family history had a strong association with both ages of onset and complications. 71 72 Large community-based studies have shown that when compared with those at average risk, people with a strong family risk were more likely to report a diagnosis of diabetes. 73 Studies done in Qatar also indicate that people with a family history of metabolic syndrome in parents, maternal aunt, maternal grandfather, and born in consanguineous marriages had high chances of developing T2DM.…”

Section: Discussionmentioning

confidence: 99%

Usefulness of Indian Diabetes Risk Score in Predicting Treatment-Induced Hyperglycemia in Women Undergoing Adjuvant Chemotherapy for Breast Cancer

Prasad,

Hegde,

Rao

et al. 2023

South Asian J Cancer

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In the curative treatment of cancer with adjuvant chemotherapy, antineoplastic drugs, along with glucocorticoids, can induce hyperglycemia. The objective of this study was to assess the utility of the Indian Diabetes Risk Score (IDRS) in predicting treatment-induced hyperglycemia in women who were nondiabetic and normoglycemic at the start of chemotherapy. This prospective study was conducted with nondiabetic women who required adjuvant chemotherapy. Participants voluntarily completed the IDRS, providing information on age, waist circumference, family history of diabetes, and physical activity. Chemotherapy-induced hyperglycemia was defined as fasting blood glucose levels ≥100 mg/dL or random blood glucose levels ≥140 mg/dL during treatment. Data were categorized into women who developed hyperglycemia and those who remained normoglycemic during treatment and were analyzed using Fisher's exact test. A significance level of p < 0.05 was applied. Receiver operating characteristic (ROC) curves were constructed to validate the IDRS for predicting hyperglycemia. A total of 208 women met the inclusion criteria and participated in the study. The results revealed that 38.93% (81/208) developed hyperglycemia by the end of chemotherapy, as observed during their first follow-up after treatment. Fisher's exact test demonstrated a significant difference in the total IDRS score and its domains, including family history, physical activity, and waist circumference (p = 0.017–< 0.001), but not age. ROC analysis indicated that an IDRS score above 60 increased the likelihood of developing hyperglycemia, with a sensitivity of 81.3%, specificity of 54.7%, and an area under the curve of 0.727. These findings suggest that the IDRS is a sensitive tool for predicting adjuvant chemotherapy-induced hyperglycemia in breast cancer patients without diabetes. To the best of the authors' knowledge, this is the first study to evaluate the utility of the IDRS in predicting treatment-induced hyperglycemia in women undergoing adjuvant chemotherapy for breast cancer. Ongoing efforts are focused on understanding the underlying mechanisms and strategies for mitigation.

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“…To the best of our knowledge, studies on associations of diabetes by gender and a family history of diabetes with depressed mood have not been reported yet. Previous studies have reported that people with diabetes with a family history of diabetes smoked more (Alharithy et al, 2018; Chang, 2012) and were diagnosed at a younger age with higher BMI, larger waist circumference, and worse cerebrovascular outcomes (Alharithy et al, 2018; Annis et al, 2005; Jali et al, 2009). In this study, diabetic patients with a family history of diabetes tended to be younger ( p = .056) and have more women ( p = .022) than those without a family history of diabetes.…”

Section: Discussionmentioning

confidence: 99%

Men With Both Diabetes and a Family History of Diabetes Were Associated With Depressed Mood in Korean Adults

2023

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Diabetes mellitus (DM) is strongly associated with depression, especially in women. This study was designed to investigate the gender-specific association between DM and depressive mood by family history of diabetes. Data from the Korea National Health and Nutrition Examination Survey, a population-based cross-sectional survey in 2020, were used. Of 6,133 participants aged 19 years or older, 4,259 participants were included after excluding participants without data of laboratory or physical examination, medical or family history of diseases, or depression scores of Patient Health Questionnaire–9. We examined associations of glucose and insulin metabolism, and DM with depressed mood by sex and family history of diabetes using logistic regression analyses with three stepwise models. In men, fasting glucose and HbA1c (odds ratio [OR]: 1.25, 95% confidence interval [CI]: [1.10, 1.42]) levels were significantly associated with depressed mood. Men with DM and a family history of diabetes were also significantly associated with depressed mood (OR: 1.84, 95% CI: [1.12, 3.05]), whereas DM without a family history showed no association. In women, glucose and insulin metabolism had no associations with depressed mood, and DM was also not associated with depressed mood regardless of a family history of diabetes. In Korean adults, DM with a family history of diabetes and glucose metabolism showed significant associations with depressed mood in men, but not in women. Our results suggest that men with both DM and a family history of diabetes should be paid more attention to depressed moods, considering ethnic characteristics.

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Type 1 diabetes mellitus with ketoacidosis in infancy

Cited by 5 publications

References 7 publications

Heavy metals, islet function and diabetes development

Heavy metals, islet function and diabetes development

Usefulness of Indian Diabetes Risk Score in Predicting Treatment-Induced Hyperglycemia in Women Undergoing Adjuvant Chemotherapy for Breast Cancer

Men With Both Diabetes and a Family History of Diabetes Were Associated With Depressed Mood in Korean Adults

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