Type 1 Diabetes Mellitus and Periodontal Health

Buduneli, Nurcan

doi:10.1007/s40496-022-00322-z

Cited by 1 publication

(2 citation statements)

References 54 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There have been a few clinical studies exploring the relationship between T1DM and periodontitis in the past, and there is significant heterogeneity between these studies in assessing clinical periodontal status. Because most studies on T1DM involve children or adolescents, the relationship between periodontitis and T1DM at the crossover level is not as clear as that with T2DM ( 45 ). Sanz et al.…”

Section: Diabetes Is a Main Risk Factor For Periodontal Diseasementioning

confidence: 99%

“…Although the number of recent studies involving the relationship between periodontitis and T1DM has increased exponentially, there is still no general consensus on the causal cause–effect relationship between periodontitis and T1DM ( 45 ), and the connection between periodontitis and T1DM does not appear to be as strong as the link with T2DM ( 49 ). Many systematic reviews have failed to demonstrate the causal relationship between them.…”

Section: Diabetes Is a Main Risk Factor For Periodontal Diseasementioning

confidence: 99%

See 1 more Smart Citation

Diabetes mellitus promotes susceptibility to periodontitis—novel insight into the molecular mechanisms

Zhao,

Xie,

Gao

et al. 2023

Front. Endocrinol.

View full text Add to dashboard Cite

Diabetes mellitus is a main risk factor for periodontitis, but until now, the underlying molecular mechanisms remain unclear. Diabetes can increase the pathogenicity of the periodontal microbiota and the inflammatory/host immune response of the periodontium. Hyperglycemia induces reactive oxygen species (ROS) production and enhances oxidative stress (OS), exacerbating periodontal tissue destruction. Furthermore, the alveolar bone resorption damage and the epigenetic changes in periodontal tissue induced by diabetes may also contribute to periodontitis. We will review the latest clinical data on the evidence of diabetes promoting the susceptibility of periodontitis from epidemiological, molecular mechanistic, and potential therapeutic targets and discuss the possible molecular mechanistic targets, focusing in particular on novel data on inflammatory/host immune response and OS. Understanding the intertwined pathogenesis of diabetes mellitus and periodontitis can explain the cross-interference between endocrine metabolic and inflammatory diseases better, provide a theoretical basis for new systemic holistic treatment, and promote interprofessional collaboration between endocrine physicians and dentists.

show abstract

Section: Diabetes Is a Main Risk Factor For Periodontal Diseasementioning

confidence: 99%

Section: Diabetes Is a Main Risk Factor For Periodontal Diseasementioning

confidence: 99%