Type 1 Diabetes Mellitus

Syed, Fatima

doi:10.7326/aitc202203150

Cited by 106 publications

(69 citation statements)

References 24 publications

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“…Unfortunately, the mean HbA1c across all age groups reported in the cost, coverage and care (3C) study in China remains as high as 8.9%, and most T1DM individuals fail to achieve desired glycemic control (HbA1c less than 7.5%) ( 4 , 5 ). The optimal management of T1DM patients requires adherence to both lifestyle management and therapeutic regimens ( 6 ). The self-management of diabetes is necessary to achieve treatment goals for individuals with T1DM ( 7 ).…”

Section: Introductionmentioning

confidence: 99%

Effect of the Chinese New Year Public Holiday on the Glycemic Control of T1DM With Intensive Insulin Therapy

Guo

Zhang

et al. 2022

Front. Endocrinol.

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AimsThere is limited evidence that evaluates the glycemic control of type 1 diabetes mellitus (T1DM) during the Chinese New Year public holiday in China. The Chinese New Year public holiday represents various challenges to glycemic control, especially in T1DM patients, in China. We aimed to assess the effect of the Chinese New Year public holiday on several glucose metrics using flash glucose monitoring (FGM) in patients with T1DM.MethodsComplete FGM data for 1 week before, 1 week during and 1 week after the Chinese New Year public holiday were available for 71 T1DM patients treated with multiple daily insulin injection (MDI) therapy (n = 51) or continuous subcutaneous insulin infusion (CSII) treatment (n = 20). The mean age of the study participants was 13 (9, 30) years. Of note, 59.2% of the patients (n = 42) were adults, and 40.8% of the patients (n = 29) were minors. The interval between each two adjacent periods was one week. The indicators of mean glucose, glucose variability and time in different glycemic ranges were analyzed.ResultsThe Chinese New Year public holiday was associated with an increase in mean blood glucose (8.4 ± 1.7 vs. 9.2 ± 2.5; P < 0.001) and time above range (TAR) (27.9% ± 16.6% vs. 35.0% ± 22.3%; P< 0.001) but a decrease in time in range (TIR) (65.1% ± 15.5% vs. 58.0% ± 19.0%; P < 0.001) and coefficient of variation (CV) (65.1% ± 15.5% vs. 58.0% ± 19.0%; P < 0.001). There was no significant difference in time below range (TBR). The glycemic control deteriorated during the Chinese New Year public holiday in our study population regardless of age. Interestingly, in the CSII group, none of the metrics of glucose control significantly changed during the Chinese New Year public holiday.ConclusionsThese results suggested that less self-management may worsen glycemic control in the short term, indicating a need for more refined management algorithms during the Chinese New Year public holiday for T1DM patients.

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Section: Introductionmentioning

confidence: 99%

Effect of the Chinese New Year Public Holiday on the Glycemic Control of T1DM With Intensive Insulin Therapy

Guo

Zhang

et al. 2022

Front. Endocrinol.

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“…During the development of type 1 diabetes, there is often a significant weight loss due to decreased insulin secretion before the diagnosis. Rapid weight gain often occurs after insulin administration [ 33 , 34 , 35 ]. Some patients start to reduce their insulin dose in order to reduce their weight gain, causing subsequent weight loss.…”

Section: Anorexia Nervosamentioning

confidence: 99%

Are the Effects of Malnutrition on the Gut Microbiota–Brain Axis the Core Pathologies of Anorexia Nervosa?

Frostad

2022

Microorganisms

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Anorexia nervosa (AN) is a disabling, costly, and potentially deadly illness. Treatment failure and relapse after treatment are common. Several studies have indicated the involvement of the gut microbiota–brain (GMB) axis. This narrative review hypothesizes that AN is driven by malnutrition-induced alterations in the GMB axis in susceptible individuals. According to this hypothesis, initial weight loss can voluntarily occur through dieting or be caused by somatic or psychiatric diseases. Malnutrition-induced alterations in gut microbiota may increase the sensitivity to anxiety-inducing gastrointestinal hormones released during meals, one of which is cholecystokinin (CCK). The experimental injection of a high dose of its CCK-4 fragment in healthy individuals induces panic attacks, probably via the stimulation of CCK receptors in the brain. Such meal-related anxiety attacks may take part in developing the clinical picture of AN. Malnutrition may also cause increased effects from appetite-reducing hormones that also seem to have roles in AN development and maintenance. The scientific background, including clinical, microbiological, and biochemical factors, of AN is discussed. A novel model for AN development and maintenance in accordance with this hypothesis is presented. Suggestions for future research are also provided.

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“…Type 1 diabetes mellitus (T1DM), with insulin-secreting pancreatic β-cells incorrectly destroyed by the immune system, has affected millions of people worldwide. [1,2] Up to the present time, injection with exogenous insulin every day is still the most commonly used strategy to control blood glucose for T1DM treatment. [3] However, the administration of exogenous insulin cannot satisfy the regulation of blood glucose realized by β-cells and is still associated with a high risk of diabetes complications.…”

Section: Introductionmentioning

confidence: 99%

Microfluidic Production of Zwitterion Coating Microcapsules with Low Foreign Body Reactions for Improved Islet Transplantation

Xiao

Wei

et al. 2022

Small

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Type 1 Diabetes Mellitus

Cited by 106 publications

References 24 publications

Effect of the Chinese New Year Public Holiday on the Glycemic Control of T1DM With Intensive Insulin Therapy

Effect of the Chinese New Year Public Holiday on the Glycemic Control of T1DM With Intensive Insulin Therapy

Are the Effects of Malnutrition on the Gut Microbiota–Brain Axis the Core Pathologies of Anorexia Nervosa?

Microfluidic Production of Zwitterion Coating Microcapsules with Low Foreign Body Reactions for Improved Islet Transplantation

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