Type 1 diabetes in the offspring does not increase the risk of parental Type 2 diabetes in South Indians

Abstract

Objectives (a) To study whether there was an increased prevalence of glucose intolerance in the parents of probands with Type 1 diabetes and (b) to look for any possible link between the glucose intolerance in the parents with HLA-DQB1 alleles transmitted in excess to the Type 1 diabetes offspring.Study Design and Methods From 215 families of South Indian Type 1 diabetes probands, 336 parents (170 fathers, age 30±70 years; 166 mothers, age 23±72 years) were studied by oral glucose tolerance test (GTT). Glucose intolerance in the parents was compared with the population data available. HLA-DQB1 alleles in 170 of the families were studied by the Olerup method (based on sequence speci®c primers) and the transmission disequilibrium test (TDT) was used to determine the Type 1 diabetes-associated DQB1 alleles.

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“…[9] In the research conducted by Ramchandran, no significant change was observed in males and females diabetic people (301 vs. 307) (P < 0.62). [10] The prevalence of diabetes in females and males in this research was reported 32.4% and 22.2%, respectively (P < 0.05).…”

“…However, in previous studies, this increase of prevalence was seen in the age group of 51-56 years. [9,10] The lowest age of diabetes belongs to people aged 71 years, which it is due to an increase in mortality in this age group. Thus, it could be stated that the reduced prevalence of diabetes in people aged over 60 years old in Iran is due to increased mortality in this age group.…”