Type 1 and type IV hypersensitivity to nickel

Abstract

We report a case of type 1 and type IV contact hypersensitivity to nickel. Very few cases of immediate contact urticaria to nickel have been reported. The mechanism behind this is not fully understood, although it has been postulated that nickel may act as a mast cell discharger on a non-immunological basis. Nickel is found in varying concentrations in stainless steels; its biological availability varies depending on the alloy composition. Our patient has adapted her lifestyle to minimize her contact with household appliances containing nickel. If medical or dental treatment using stainless steel equipment is required, we recommend a short course of oral corticosteroids and antihistamines.

The Effect of Hydrofluoric Acid Surface Treatment on the Cyclic Fatigue Resistance of K3 NiTi Instruments

“…The rougher surface and larger surface area tend to have more corrosion than smoother and smaller surface area. The surface corrosion of NiTi alloy could release nickel ion that can evoke allergic reactions [26] in contacting tissues. In this sense, HF treatment which resulted in smoother surface in this experiment is postulated to contribute to increasing the cyclic fatigue resistance of NiTi files as well as lowering the corrosion tendency of them.…”

Nickel dental alloys can induce laryngeal edema attacks: A case report

“…These usually consisted of vesicular hand eczema or systemic contact dermatitis . Very few cases of immediate and delayed hypersensitivity, presenting mostly with contact urticaria, have been reported . Finally, a patient with a systemic nickel allergy presenting as papuloerythroderma‐like eruptions was described .…”

“…7,8 Very few cases of immediate and delayed hypersensitivity, presenting mostly with contact urticaria, have been reported. 5 Finally, a patient with a systemic nickel allergy presenting as papuloerythroderma-like eruptions was described. 9 This case benefited from a nickel-free diet and the removal of dental braces was not necessary.…”

“…Very few cases of type I hypersensitivity to nickel with clinical symptoms consisting of contact urticaria have been reported. 5 Here, we present a case of a nickel allergic patient displaying frequent laryngeal edema attacks for 4 months until the correct diagnosis was made and the causative factor was eliminated.…”

Contact Dermatitis in the Atopic Child

“…2 Indeed, it has been demonstrated that Th1 and Th2 reactions are not mutually exclusive and can occur concurrently in atopic patients. 23 Thus, it is notable that nickel, which consistently tops the list of clinically relevant allergens in multiple studies, 9,15,16 is not only capable of inducing both type I and type IV hypersensitivity reactions, 24 but has also been shown to induce higher rates of contact allergy in those with lossof-function filaggrin gene mutations, commonly seen in atopic patients. 25 More than one study has demonstrated that the rate of contact Th1 and Th2 reactions are not mutually exclusive and can occur concurrently in atopic patients.…”