Type 1 and 2 Myocardial Infarction and Myocardial Injury: Clinical Transition to High-Sensitivity Cardiac Troponin I

Sandoval, Yader; Smith, Stephen W.; Sexter, Anne; Thordsen, Sarah E.; Bruen, Charles; Carlson, Marjorie; Dodd, Kenneth W.; Driver, Brian E.; Hu, Yan; Jacoby, Katherine; Johnson, Benjamin K.; Love, Sara A.; Moore, Johanna C.; Schulz, Karen; Scott, Nathaniel L.; Apple, Fred S.

doi:10.1016/j.amjmed.2017.05.049

Cited by 105 publications

(93 citation statements)

References 18 publications

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“…The baseline clinical characteristics and treatment of patients with T2MI are summarized in Table . The mean age of patients with T2MI was over 60 years; most studies revealed that the percentage of male patients ranged from 52.8% to 98.6% in patients with T2MI, but the studies of Szymariski et al, Sandoval et al, and Arora et al found percentages of female patients of 60.3%, 59%, and 51.9%, respectively .…”

Section: Resultsmentioning

confidence: 99%

“…The baseline clinical characteristics and treatment of patients with T2MI are summarized in Table 1. 4,[12][13][14][15][16][17][18][19][20][21][22][23][24] The mean age of patients with T2MI was over 60 years; most studies revealed that the percentage of male patients ranged from 52.8% to 98.6% in patients with T2MI, found percentages of female patients of 60.3%, 59%, and 51.9%, respectively. 17,18,24 The ratio of patients with T2MI presenting with non-ST segment elevation myocardial infarction (NSTEMI) ranged from 70.1% to 97.5% (mean value: 87.1%); all studies found that patients with T2MI often had previous relevant medical history, but EI-Haddad et al did not describe medical history findings.…”

Section: Resultsmentioning

confidence: 99%

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A systematic review on the triggers and clinical features of type 2 myocardial infarction

Wang

Zhao

Zhong

et al. 2019

Clinical Cardiology

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Little is known about the correlation between triggering factors, clinical characteristics, diagnosis, and prognosis of patients with type 2 myocardial infarction (T2MI). The triggers and features of T2MI are linked to its diagnosis and prognosis. The Preferred Reporting Items for Systematic Reviews and Meta‐Analyses (PRISMA) guidelines were followed. A structured search of three databases (PubMed, Embase, and Medline) was undertaken to identify peer‐reviewed articles related to the triggers and clinical features of T2MI published between January 2012 and August 2018. Seven retrospective cohort studies and seven prospective cohort studies involving 3867 patients with T2MI were included. All selected studies were rated as being of high or acceptable quality. Nine studies revealed that the leading trigger of T2MI was arrhythmia, especially tachyarrhythmia. Six studies revealed that the proportion of single‐trigger T2MIs was higher than that of multiple triggers and two studies showed that two‐trigger cases formed the majority of multiple trigger cases. All included studies found that a greater prevalence of T2MI in the older population. Thirteen studies revealed that the patients with T2MI often had a previous relevant medical history. The leading trigger of T2MI is arrhythmia, especially tachyarrhythmia, and the majority of cases arise from a single trigger. Two‐trigger is the most common form of multiple‐trigger T2MI, which often occurs in older patients with cardiovascular risk factors or comorbidities. Non‐cardiovascular causes may be the triggering factors and are strongly associated with the diagnosis, treatment, and prognosis of T2MI.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

A systematic review on the triggers and clinical features of type 2 myocardial infarction

Wang

Zhao

Zhong

et al. 2019

Clinical Cardiology

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“…B. eine Aortenklappenstenose vorliegen können [6]. Unter diesem Aspekt ist es beunruhigend, dass gerade diese Patienten im Vergleich zur Kohorte mit Typ-I-MI in geringerem Maße medikamentöse Prävention hinsichtlich des kardiovaskulären Risikoprofils erhalten [11] auch weil sich in dieser heterogenen Gruppe etliche Patienten mit primär niedrigerer Prätestwahrscheinlichkeit für eine koronare Herzerkrankung befinden.…”

Section: Kur Zgefasstunclassified

„Myocardial injury“ und Myokardinfarkt – Konsequenzen für die Klinik im Kontext aktueller Leitlinien

Wild

Wenzel

2019

Aktuel Kardiol

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ZusammenfassungIm 2018 veröffentlichten Konsensus-Papier „Universal Definition of Myocardial Infarction“ der Europäischen und der Amerikanischen Gesellschaft für Kardiologie (ESC/ACC) erfolgte eine detaillierte Unterscheidung zwischen „Myocardial injury“ und Myokardinfarkt. Für die Diagnose der „Myocardial injury“ sind hierbei allein erhöhte Troponinwerte erforderlich. Zeigen sich neben der laborchemisch messbaren Myokardschädigung auch klinische Zeichen der Ischämie, ergibt sich die Diagnose Myokardinfarkt. Eine „Myocardial injury“ kann durch eine Vielzahl an kardialen und extrakardialen Erkrankungen verursacht werden und übertrifft sogar den Myokardinfarkt, was die Mortalität betrifft. Gerade durch die Heterogenität der Ursachen stellt die „Myocardial injury“ im klinischen Alltag eine besondere Herausforderung dar.

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“…10,29 Rates of obstructive CAD in T2MI patients undergoing coronary angiography range from 28% to 78%. 3,8,9,27 Despite a high prevalence of CAD in these patients, significant disparities exist in medical management of even those with CAD in T2MI or myocardial injury, when compared with those with T1MI 1,3,4,[8][9][10][11][12]14,15,[19][20][21][22][23][24][25][26][27] (Table 2).…”

Section: Introductionmentioning

confidence: 99%

Wake Forest University long‐term follow‐up of type 2 myocardial infarction: The Wake‐Up T2MI Registry

Jogu

Arora

Vaduganathan

et al. 2019

Clinical Cardiology

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Background The Wake‐Up T2MI Registry is a retrospective cohort study investigating patients with type 2 myocardial infarction (T2MI), acute myocardial injury, and chronic myocardial injury. We aim to explore risk stratification strategies and investigate clinical characteristics, management, and short‐ and long‐term outcomes in this high‐risk, understudied population. Methods From 1 January 2009 to 31 December 2010, 2846 patients were identified with T2MI or myocardial injury defined as elevated cardiac troponin I with at least one value above the 99th percentile upper reference limit and coefficient of variation of 10% (>40 ng/L) and meeting our inclusion criteria. Data of at least two serial troponin values will be collected from the electronic health records to differentiate between acute and chronic myocardial injury. The Fourth Universal Definition will be used to classify patients as having (a) T2MI, (b) acute myocardial injury, or (c) chronic myocardial injury during the index hospitalization. Long‐term mortality data will be collected through data linkage with the National Death Index and North Carolina State Vital Statistics. Results We have collected data for a total of 2205 patients as of November 2018. The mean age of the population was 65.6 ± 16.9 years, 48% were men, and 64% were white. Common comorbidities included hypertension (71%), hyperlipidemia (35%), and diabetes mellitus (30%). At presentation, 40% were on aspirin, 38% on β‐blockers, and 30% on statins. Conclusion Improved characterization and profiling of this cohort may further efforts to identify evidence‐based strategies to improve cardiovascular outcomes among patients with T2MI and myocardial injury.

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Type 1 and 2 Myocardial Infarction and Myocardial Injury: Clinical Transition to High-Sensitivity Cardiac Troponin I

Cited by 105 publications

References 18 publications

A systematic review on the triggers and clinical features of type 2 myocardial infarction

A systematic review on the triggers and clinical features of type 2 myocardial infarction

„Myocardial injury“ und Myokardinfarkt – Konsequenzen für die Klinik im Kontext aktueller Leitlinien

Wake Forest University long‐term follow‐up of type 2 myocardial infarction: The Wake‐Up T2MI Registry

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