Tympanic Perforation Closure With Autogenous Fresh Vein: Experimental Study in Dogs

Myringoplasty by Homogenous Vein Graft

“…In any graft, it is the basement membrane (of skin) or the adventitia (of vein) which contacts the middle fibrous layer of the drum, and this mesodermal tissue is stimulated and the connective tissue cells and vascular endothelium proliferate, while the fibrin serves as a scaffolding. A bridge is provided for the epithelium to cross the defect, and vein may be preferable in contributing elastic fibres to close the gap (Guilford, 1964 andWilliams, .1965).…”

Pathology as it relates to ear surgery

“…(1963) evaluated middle ear grafting in cats. The results of experimental tympanoplasty were also reported in rabbits (Portmann and Gerard, 1963), dogs (Guilford et al 1964) and squirrel monkeys (Paparella, 1967). Paparella performed a series of experiments on eighty-four ears to evaluate myringoplasty, mucosal regeneration, graft fistula and window characteristics.…”