Tympanic membrane repair using silk fibroin and acellular collagen scaffolds

Abstract

The results of this study show that SFS and ACS are effective graft materials and may be utilized as alternatives to current grafts for TM repair.

Searching for a rat model of chronic tympanic membrane perforation: Healing delayed by mitomycin C/dexamethasone but not paper implantation or iterative myringotomy

“…To assess TMP patency, all 40 rats underwent otoscopic observation under general anesthesia postoperatively on day 0, 1, 3,5,7,9,11,14,17,21,28,35,42,49 and 56 using an otomicroscope and digital video-otoscope. The TMPs were assessed for closure, infection, opacification, thickening and granulation tissue.…”

“…In order to fully examine the efficacy of a novel graft, a chronic TMP animal model that mimics the clinical condition of chronic TMPs in patients is paramount. In the current literature, various animal models have been reported, including rat [2], mouse [3], chinchilla [4], guinea pig [5] and dog [6]. However, these models are mostly of acute TMPs and not useful for assessment of materials for myringoplasty or tympanoplasty on chronic TMPs.…”

Plasminogen initiates and potentiates the healing of acute and chronic tympanic membrane perforations in mice

“…The most common way to treat chronic TM perforations is through surgery. Over the years, various tissues and materials as well as a variety of surgical procedures have been used with different success rates [19,20]. However, the cost of surgery is high and the burden on both the patients and the healthcare system is great.…”

A prospective cohort study of the silk fibroin patch in chronic tympanic membrane perforation

“…Recent advances in tissue engineering and biomaterial research have suggested alternative material for TM regeneration . Silk, collagen, chitosan, and calcium alginate have been studied as TM patching materials and have shown favorable results in animal and clinical studies of acute traumatic TM perforation . Among these options, silk fibroin has high biocompatibility and can heal the perforated TM in animal models .…”

“…7 Silk, collagen, chitosan, and calcium alginate have been studied as TM patching materials and have shown favorable results in animal and clinical studies of acute traumatic TM perforation. [7][8][9] Among these options, silk fibroin has high biocompatibility and can heal the perforated TM in animal models. 10,11 Silk fibroin patches (Tympasil; Daewoong-Bio, Seoul, Korea) are thin transparent patches produced from silk fibroin ( Fig.…”