Twofold Mechanosensitivity Ensures Actin Cortex Reinforcement upon Peaks in Mechanical Tension
Valentin Ruffine,
Andreas Hartmann,
Annika Frenzel
et al.
Abstract:The actin cortex is an active polymer network underneath the plasma membrane at the periphery of mammalian cells. It is a major regulator of cell shape through the generation of active cortical tension. In addition, the cortex constitutes a mechanical shield that protects the cell during mechanical agitation. Cortical mechanics is tightly controlled by the presence of actin cross‐linking proteins that dynamically bind and unbind actin filaments. Cross‐linker actin bonds are weak non‐covalent bonds whose bond l… Show more
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