Two years oral use of chlorhexidine in man

Nuki, Klaus; Schlenker, R.A.; Löe, Harald; Cr, Schiött

doi:10.1111/j.1600-0765.1976.tb00066.x

Cited by 22 publications

(3 citation statements)

References 11 publications

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“…Students were of both gender and aged 20 to 25 years. They were excluded from the study if any of the following were present: (1) less than 20 teeth; (2) pre-sence of periodontal disease (3) presence of factors of plaque retention (clinically unacceptable restorations, important carious, dental overlapping, removable prosthesis, faulty fixed prosthesis, orthodontic appliances), (4) associated systemic diseases (diabetes, heart disorders, blood diseases, VIH infection), (5) use of antibiotics or other anti-inflammatory drugs during the 3 latest months, (6) known allergy against components of mouth rinses, (7) pregnancy, (8) smoking.…”

Section: Methodsmentioning

confidence: 99%

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Chlorhexidine alcohol base mouthrinse versus Chlorhexidine formaldehyde base mouthrinse efficacy on plaque control: Double blind, randomized clinical trials

Ennibi¹,

Lakhdar²,

Bouziane³

et al. 2013

Med Oral

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Background: Chlorhexidine is well known for its antiplaque effect. However, the mouthrinse based chlorhexidine antiplaque efficiency may vary according to the formulation of the final product. The aim of the present study was to compare anti-plaque effectiveness of two commercial mouthrinses: 0.12 % Chlorhexidine alcohol base (CLX-A) versus a diluted 0.1% Chlorhexidine non-alcohol base with 0.1% of Formaldehyde (CLX-F). Material and Methods: the study was a seven day randomized, double-blind, placebo-controlled trial including 30 volunteers. At the start, all participants received a dental prophylaxis. Over 7 days experimental non-brushing period, during which subjects abstained from all forms of mechanical oral hygiene, one group test rinsed twice daily with 15ml of an alcohol base 0.12% Chlorhexidine mouthrinse. The second group test used 15ml of alcohol free 0.1% Chlorhexidine mouthrinse base 0.1% formaldehyde twice daily. The negative control group used a placebo. Plaque indexes were recorded in all volunteers prior to treatment at Day 0, 1 and 7. Results: After 7 days, the mean plaque index for the first group was 0.76±0.38 compared with a mean plaque index of 1.43±0.56 for the second group. The difference in plaque scores between the groups was statistically significant. Conclusion: the results of this study showed that rinsing with an alcohol base 0.12% Chlorhexidine mouthrinse is significantly different from rinsing with an alcohol free 0.1% Chlorhexidine mouthrinse on plaque inhibition. Key words:Chlorhexidine, dental plaque, mouthrinse, alcohol, formaldehyde.

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Section: Methodsmentioning

confidence: 99%

“…As a result of previous clinical studies, 0.2 % chlorhexidine mouthrinse (CLX) has become the international standard (3-8). …”

Section: Introductionmentioning

confidence: 99%

Chlorhexidine alcohol base mouthrinse versus Chlorhexidine formaldehyde base mouthrinse efficacy on plaque control: Double blind, randomized clinical trials

Ennibi¹,

Lakhdar²,

Bouziane³

et al. 2013

Med Oral

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show abstract

“…Historically, chlorhexidine has been considered a safe and effective antimicrobial agent to control plaque and gingivitis. 1,2,3,4,5,6,7 These properties have stood the test of time with chlorhexidine still regarded as the most effective chemical antiplaque agent. According to Addy, "Chlorhexidine has not been superceded as a chemical antiplaque agent, although other compounds have been shown to be useful."…”

Section: Introductionmentioning

confidence: 99%

Use of a Whitening Dentifrice for Control of Chlorhexidine Stain

Tillis

Rdh²,

Ma³

1999

The Journal of Contemporary Dental Practice

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A major drawback to clinicians prescribing and patients using chlorhexidine rinse is the development of extrinsic staining. In order to assess the effectiveness of a whitening dentifrice in controlling chlorhexidine stain, fifty-seven subjects rinsed with chlorhexidine twice daily while brushing twice daily with either fluoridated whitening or a fluoridated regular dentifrice. Stain was assessed at 1, 2, and 3 month intervals using a stain index with two components; one with parameters for color intensity and one for tooth percentage covered with stain. Facial surfaces accumulated less stain than lingual surfaces. For many, although not all surfaces, and at many, although not all time periods, the group utilizing the whitening dentifrice exhibited less staining.It is advantageous to recommend a whitening dentifrice that has demonstrated stain suppression when prescribing a chlorhexidine rinse. Improved patient satisfaction leading to increased compliance with the antimicrobial regimen is a desired outcome.

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Effects of proprietary oral rinses containing chlorhexidine, hexetidine and benzydamine on the proliferation of human buccal epithelial cells in culture

Shakespeare

Evans

1988

Archives of Oral Biology

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Two years oral use of chlorhexidine in man

Cited by 22 publications

References 11 publications

Chlorhexidine alcohol base mouthrinse versus Chlorhexidine formaldehyde base mouthrinse efficacy on plaque control: Double blind, randomized clinical trials

Chlorhexidine alcohol base mouthrinse versus Chlorhexidine formaldehyde base mouthrinse efficacy on plaque control: Double blind, randomized clinical trials

Use of a Whitening Dentifrice for Control of Chlorhexidine Stain

Effects of proprietary oral rinses containing chlorhexidine, hexetidine and benzydamine on the proliferation of human buccal epithelial cells in culture

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