Two‐year‐supervised resistance training prevented diabetes incidence in people with prediabetes: A randomised control trial

Dai, Xin; Zhai, Lu; Chen, Qing‐Yun; Miller, Joshua D.; Li, Lu; Hsue, Cunyi; Liu, Lin; Yuan, Xun; Wei, Wei; Fang, Zhaohui; Zhao, Wenpiao; Liu, Yuhua; Huang, Feng; Lou, Qingqing

doi:10.1002/dmrr.3143

Cited by 34 publications

(43 citation statements)

References 29 publications

(43 reference statements)

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“…Some evidence suggests that supervised resistance-training programs using WB-EMS can improve cardiometabolic outcomes in untrained individuals [10][11][12][13], mostly driven by modifications in body composition. This is also in line with current knowledge suggesting that even resistance training -and not only aerobic exercise -can be effective in improving glycemic control and dyslipidemia in subjects with prediabetes [14][15][16]. However, to date it is not reported whether the metabolic effects previously observed with WB-EMS in overweight individuals [10,11] can be of additive value when training is performed alongside caloric restriction to promote weight loss.…”

Section: Introductionsupporting

confidence: 87%

Whole-body Electromyostimulation plus Caloric Restriction in Metabolic Syndrome

et al. 2020

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We investigated early effects of Whole-Body Electromyostimulation added to hypocaloric diet on metabolic syndrome features in sedentary middle-aged individuals. We randomly assigned 25 patients to Whole-Body Electromyostimulation plus caloric restriction or caloric restriction alone for 26 weeks. Anthropometrics, blood pressure, fasting glucose and insulin, HOMA-IR, glycated hemoglobin, lipids, uric acid, creatinphosphokynase, C-reactive protein were assessed. Body composition was evaluated with direct-segmental, multi-frequency Bioelectrical Impedance Analysis. Both groups lost approximately 10% of weight, with similar effects on waist circumference and fat mass. Change in free-fat mass was significantly different between groups (caloric restriction −1.5±0.2 vs. Whole-Body Electromyostimulation plus caloric restriction +1.1±0.4 kg, p=0.03). Whole-Body Electromyostimulation plus caloric restriction group experienced greater percent reductions in insulin (−45.5±4.4 vs. −28.2±3.6%, p=0.002), HOMA-IR (–51.3±3.2 vs. –25.1±1.8%, p=0.001), triglycerides (−22.5±2.9 vs. −4.1±1.6%, p=0.004) and triglycerides/HDL (p=0.028). Subjects trained with Whole-Body Electromyostimulation had also significant improvement in systolic pressure (138±4 vs. 126±7 mmHg, p=0.038). No discontinuations for adverse events occurred. In middle-aged sedentary subjects with the metabolic syndrome, Whole-Body Electromyostimulation with caloric restriction for 26 weeks can improve insulin-resistance and lipid profile compared to diet alone. Further studies are needed to ascertain long-term efficacy and feasibility of this approach in individuals with the metabolic syndrome.

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Section: Introductionsupporting

confidence: 87%

Whole-body Electromyostimulation plus Caloric Restriction in Metabolic Syndrome

et al. 2020

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“…However, the greatest reductions in HbA1c were experienced by individuals undertaking combined resistance and aerobic exercise 127. Furthermore, a recent randomized control trial (RCT) in 137 pre-diabetic adults (mean age 59 years) reported that two-year supervised resistance training alone (HR:0.35 [95%CI:0.15‐0.79]) and in combination with aerobic training (HR:0.26 [95%CI:0.11‐0.62]) were as effective as aerobic training alone (HR:0.28 [95%CI:0.13‐0.64]) in preventing progression to T2DM 128. Resistance training is the most effective strategy for improving both muscle mass and function in sarcopenic individuals,129 and is similarly effective for improving muscle strength, size, and quality and metabolic health in older adults with T2DM 130.…”

Section: Treatment and Prevention Of T2dm And Sarcopeniamentioning

confidence: 99%

<p>Sarcopenia and type 2 diabetes mellitus: a bidirectional relationship</p>

Mesinovic¹,

Zengin²,

Courten³

et al. 2019

DMSO

303

207

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The incidence and prevalence of metabolic and musculoskeletal diseases are increasing. Type 2 diabetes mellitus (T2DM) is characterized by insulin resistance, inflammation, advanced glycation end-product accumulation and increased oxidative stress. These characteristics can negatively affect various aspects of muscle health, including muscle mass, strength, quality and function through impairments in protein metabolism, vascular and mitochondrial dysfunction, and cell death. Sarcopenia is a term used to describe the agerelated loss in skeletal muscle mass and function and has been implicated as both a cause and consequence of T2DM. Sarcopenia may contribute to the development and progression of T2DM through altered glucose disposal due to low muscle mass, and also increased localized inflammation, which can arise through inter-and intramuscular adipose tissue accumulation. Lifestyle modifications are important for improving and maintaining mobility and metabolic health in individuals with T2DM and sarcopenia. However, evidence for the most effective and feasible exercise and dietary interventions in this population is lacking. In this review, we discuss the current literature highlighting the bidirectional relationship between T2DM and sarcopenia, highlight current research gaps and treatments, and provide recommendations for future research.

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“…There is evidence demonstrating muscular strength as a predictor of mortality in a healthy population [29][30][31][32][33][34]. A meta-analysis by Garcia-Hermosa and colleagues show that individuals with good upper body and lower body strength have lower risk of mortality regardless of age [29].…”

Section: Research Mortality (Heading 2 Intechopen)mentioning

confidence: 99%

Muscle Health: The Gateway to Population Health Management

Gilliam¹,

Terpeluk²

2021

Occupational Wellbeing

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The muscle on your frame is a prime indicator of health and longevity. Dr. Paul Terpeluk with the Cleveland Clinic has stated that muscular strength is the new vital sign of workplace health and safety. Research studies focusing on Type II diabetes, cardiovascular disease, musculo-skeletal injuries, certain cancers and the delay of dementia have shown a strong correlation between disease prevention and muscular strength. IPCS’ database of over 500,000 strength tests have shown a workers’ absolute strength today is at least 14% weaker than the worker 15 years ago and weighs about 8 pounds more. Over the last 10 years, there has been a significant shift by 52% with an increase in the number of workers with a BMI of 35 or greater. The Cleveland Clinic implemented a new hire muscular strength assessment to place new hire applicants into jobs that match their physical capability in 2011. The outcomes show a statistically significant reduction in number of employee health, pharmacy and workers’ compensation claims and costs with overall savings near $25 million. Musculo-skeletal health of the worker can be improved. When a worker maintains good muscular strength, the worker is more productive, has fewer medical claims and workers’ compensation claims.

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Two‐year‐supervised resistance training prevented diabetes incidence in people with prediabetes: A randomised control trial

Cited by 34 publications

References 29 publications

Whole-body Electromyostimulation plus Caloric Restriction in Metabolic Syndrome

Whole-body Electromyostimulation plus Caloric Restriction in Metabolic Syndrome

<p>Sarcopenia and type 2 diabetes mellitus: a bidirectional relationship</p>

Muscle Health: The Gateway to Population Health Management

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