Two-Year Results of the PHANTOM High Flex Trial: A Single-Arm Study on the Atlas Unicompartmental Knee System Load Absorber in Patients With Medial Compartment Osteoarthritis of the Knee

Slynarski, Konrad; Walawski, Jacek; Śmigıelski, Robert; Merwe, Willem van der

doi:10.1177/1179544119877170

Cited by 8 publications

(18 citation statements)

References 29 publications

(49 reference statements)

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“…Patients without baseline SIFK were excluded. Patients from a previously published prospective study utilizing the ISA [11] were matched to controls using the SIFK Score as detailed below in an exact manner using a matching software which matches cases and controls in a random manner (MedCalc 19.2.6, MedCalc Software Ltd, Ostend, Belgium). Patient demographic and radiographic parameters were collected.…”

Section: Accepted Manuscriptmentioning

confidence: 99%

“…[G Bode reference, Oliver Morgan reference] Twoyear results of a prospective single-arm study revealed significant benefits with regards to WOMAC pain and function scores without significant adverse effects. [11] Still, there are no comparative studies on evaluating this implant system comparted to non-operative controls with regards to progression to arthroplasty. [11] Therefore, the purpose of the current study was to evaluate whether partially unloading the knee with ISA altered the likelihood that a patient with SIFK will progress to knee arthroplasty utilizing a validated predictive risk model based on demographic and radiographic characteristics (the SIFK score).…”

Section: Introductionmentioning

confidence: 99%

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Risk of Arthroplasty in Patients with Subchondral Insufficiency Fractures of the Knee: A Matched Study of the Implantable Shock Absorber using a Validated Predictive Model

Pareek

Parkes

Slynarski³

et al. 2022

J Knee Surg

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Introduction: Subchondral insufficiency fractures of the knee (SIFK) can result in high rates of osteoarthritis and arthroplasty. The Implantable Shock Absorber (ISA) implant is a titanium and polycarbonate urethane device which reduces load on the medial compartment of the knee by acting as an extra-articular load absorber while preserving the joint. The purpose of this study was to evaluate whether partially unloading the knee with the ISA altered the likelihood of progression to arthroplasty utilizing validated predictive risk model (SIFK score). Methods: A retrospective case-control (2:1) study was performed on patients with SIFK without any previous surgery and those implanted with the ISA with outcome being progression to arthroplasty compared to non-operative treatment at 2 years. Baseline and final radiographs, as well as MRIs, were reviewed for evaluation of meniscus or ligament injuries, insufficiency fractures and subchondral edema. Patients from a prospective study were matched using the exact SIFK Score, a validated predictive score for progression to arthroplasty in patients with SIFK, to those with the ISA implant. Kaplan-Meier analysis was conducted to assess survival. Results: Total of 57 patients (38 controls:19 ISA) with mean age of 60.6 years were included. The SIFK score was matched exactly between cases and controls. The 2-year survival rate of 100% for the ISA group was significantly higher than corresponding rate of 61% for the control group (p<0.01). In ISA, 0% of the patients converted to arthroplasty at 2 years, and 5% (1 patient) had hardware removal at 1 year. When stratified by risk, the ISA group did not have a significantly higher survival compared to low-risk (p=0.3) or medium-risk (p=0.2) controls, though it had a significantly higher survival for high-risk groups at 2-years (100% vs 15%, p<0.01). Conclusion: SIFK of the medial knee can lead to significant functional limitation and high rates of conversion to arthroplasty. Implants such as the Implantable Shock Absorber have the potential to alter progression to arthroplasty in these patients, especially those at high-risk.

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Section: Accepted Manuscriptmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Risk of Arthroplasty in Patients with Subchondral Insufficiency Fractures of the Knee: A Matched Study of the Implantable Shock Absorber using a Validated Predictive Model

Pareek

Parkes

Slynarski³

et al. 2022

J Knee Surg

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“…W badaniu Slynarski i in. [16,18] dokonano oceny 26 pacjentów początkowo po 12 miesiącach leczenie następnie po 24 miesiącach leczenia. Po 12 miesiącach leczenia zaobserwowano znaczną poprawę w skali KSS z 61.9 ± 3.0 do 94.6 ± 1.6.…”

Section: Iva Atlas Knee System -Konstrukcja I Mechanizm Działaniaunclassified

“…U jednej wykonano artroskopię kolana z mikrozłamaniami. U jednego pacjenta wykonano artroskopię, usunięto łąkotkę oraz osteofity [18]. Do tej pory nie opisano w literaturze żadnej infekcji i rewizji implantu.…”

Section: Ivc Atlas Knee System -Ograniczeniaunclassified

Osteoarthritis of the knee - a condemnation of a prosthesis for a young person? ATLAS Knee System as an effective method of relieving the medial compartment of the knee

Oliwer

Walawski²,

Żelazny

et al. 2022

J Educ Health Sport

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Introduction: Osteoarthritis of the knee is one of the more common causes of disability in the elderly. In the United States, one in four adults suffers from the condition, half of whom are under the age of 65. The most commonly affected joint is the knee. A significant proportion of people in the 35-65 age range have degeneration in one compartment of the knee joint. Among the younger population, when non-operative methods are already failing and it is too early for surgery, there is a place for the ATLAS Knee System. Aim of the study: The purpose of our work is to present a new and innovative form of treatment for single-compartment osteoarthritis of the knee. Based on the available literature, to show the advantages, disadvantages and results of treatment with the ATLAS Knee System. Methods and materials: A literature review was conducted in the PubMed database, using the keywords: "Atlas Knee System"; "osteoarthritis"; "knee osteoarthritis". Results: The ATLAS system is built with an absorber that, as the knee is stretched, absorbs the forces acting on the medial compartment, while not putting stress on the rest of the knee joint. After patients use the implant, a significant reduction in pain and improvement in knee function is observed. Conclusion: Osteoarthritis is a significant health problem increasingly prevalent even among the younger population. The ATLAS system provides an alternative for younger people in whom conservative treatment has failed, while more invasive methods such as osteotomies and total or single-unit prosthetics are impossible or rejected by the patient. More studies are needed, on a larger number of people to accurately evaluate this system.

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“…71 Production of catabolic cytokines such as interleukin (IL)-1 and tumor necrosis factor (TNF)-a were decreased. Other joint-saving techniques with partial unloading such as tibial osteotomy or unicompartmental load absorbing implants (Atlas system) show clinical 72 and even structural beneficial changes. [73][74][75] Both techniques significantly reduce (medial) compartment contact pressure and peak contact pressure 76,77 and maintain joint fluid pressure oscillations as well.…”

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confidence: 99%

Knee joint distraction: moving forward

Jansen¹

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ChapterGeneral introduction Part I: Clinical outcome and patient experienceChapter 2 Knee joint distraction as treatment for osteoarthritis results in clinical and structural benefit: A systematic review and meta-analysis of the limited number of studies and patients available Chapter 3 Initial tissue repair predicts long-term clinical success of knee joint distraction as treatment for knee osteoarthritis Chapter 4 Knee joint distraction compared with high tibial osteotomy and total knee arthroplasty: Two-year clinical, radiographic, and biochemical marker outcomes of two randomized controlled trials Chapter 5 Return to sport and work after randomization for knee distraction versus high tibial osteotomy: Is there a difference? Chapter 6 Knee joint distraction in regular care for treatment of knee osteoarthritis: A comparison with clinical trial data Chapter 7 User-friendliness of a novel dedicated knee joint distraction device: Experiences from clinical practice Chapter 8 Reduction of pin tract infections during external fixation using cadexomer iodine Chapter 9 Prospective one-year follow-up of clinical efficacy of knee distraction as treatment for knee osteoarthritis by use of the KneeReviver Part II: Joint processes and working mechanisms Chapter 10 Joint distraction for osteoarthritis: Clinical evidence and molecular mechanisms Chapter 11 Performance of Knee Image Digital Analysis of radiographs of patients with severe end-stage knee osteoarthritis Chapter 12 Comparison between 2D radiographic weight-bearing joint space width and 3D MRI non-weight-bearing cartilage thickness measures in the knee using non-weight-bearing 2D and 3D CT as an intermediary Chapter 13 Knee joint distraction results in MRI cartilage thickness increase up to ten years after treatment Chapter 14 Changes in cartilage thickness and denuded bone area after knee joint distraction and high tibial osteotomy: Post-hoc analyses of two randomized controlled trials Chapter 15 Cartilage collagen structure upon knee joint distraction and high tibial osteotomy as measured with T2-mapping MRI Chapter 16 The molecular profile of synovial fluid changes upon joint distraction and is associated with clinical response in knee osteoarthritis Chapter 17 Cartilage repair activity during joint-preserving treatment may be accompanied by osteophyte formation Chapter 18 Exploring subchondral bone changes measured with CT after joint distraction treatment for end stage knee osteoarthritis Chapter 19 Summary and general discussion Addendum Nederlandse samenvatting Dankwoord/acknowledgements List of publications List of conference abstracts Curriculum vitae Knee osteoarthritisOsteoarthritis Osteoarthritis (OA) is the most common chronic musculoskeletal disorder, affecting more than 300 million people worldwide. 12 Prevalence is expected to rise with an aging population and increasing obesity, as both are related to incidence and prevalence of OA. 13 The knee is a frequent site of OA, involving the entire joint, encompassing bone, cartilage, and synovium. 14 Bone...

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Two-Year Results of the PHANTOM High Flex Trial: A Single-Arm Study on the Atlas Unicompartmental Knee System Load Absorber in Patients With Medial Compartment Osteoarthritis of the Knee

Cited by 8 publications

References 29 publications

Risk of Arthroplasty in Patients with Subchondral Insufficiency Fractures of the Knee: A Matched Study of the Implantable Shock Absorber using a Validated Predictive Model

Risk of Arthroplasty in Patients with Subchondral Insufficiency Fractures of the Knee: A Matched Study of the Implantable Shock Absorber using a Validated Predictive Model

Osteoarthritis of the knee - a condemnation of a prosthesis for a young person? ATLAS Knee System as an effective method of relieving the medial compartment of the knee

Knee joint distraction: moving forward

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