Two-Year Prospective Follow-Up of Children With a Prepubertal and Early Adolescent Bipolar Disorder Phenotype

Geller, Barbara; Craney, James L.; Bolhofner, Kristine; Nickelsburg, Michael J.; Williams, Marlene; Zimerman, Betsy

doi:10.1176/appi.ajp.159.6.927

Cited by 276 publications

(230 citation statements)

References 39 publications

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“…59 Several reports have described atypical mania-like symptoms in young children. [60][61][62][63][64] Geller and colleagues published the first prospective follow-up study of prepubertal children diagnosed with mania. 63 The baseline intake episode of mania represented the first manic episode for over 80% of the sample.…”

Section: Follow-up Studies Of Clinical Samplesmentioning

confidence: 99%

“…[65][66][67] Researchers describing samples of chronically ill very young children with psychotic features, agitation, irritability, labile mood, impulse-control difficulties, cognitive deficits, and major impairment in functioning have concluded that these children exhibit a subform of mania, or pediatric mania. 34,[62][63][64]68,69 The manic diagnostic decision appears heavily weighted on persistent and pervasive irritability and chronic overactivity. It is difficult to interpret what these children actually suffer from.…”

Section: Follow-up Studies Of Clinical Samplesmentioning

confidence: 99%

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Does Bipolar Disorder Exist in Children? A Selected Review

Duffy

2007

Can J Psychiatry

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Although there is increasing recognition that a substantial proportion of patients with bipolar disorder (BD) experience an onset of illness in adolescence, significant controversy remains over the validity of the diagnosis in very young children. In careful studies of adult patients dating from Kraepelin, first mood episodes not uncommonly occurred during adolescence. Some of these early-onset patients experienced subthreshold mood disturbances or predisposing temperaments earlier in childhood. Earlier onsets of BD have been reported in more recent clinical and community samples of children. Several factors possibly contributed to these earlier onsets, including exposure to psychotropics, bias in favour of a mood rather than a psychotic diagnosis, and recognition of softer-spectrum BDs. However, the validity of the diagnosis of BD in impulsive, irritable, labile, or behaviourally dysregulated children remains to be proven. Studies of high-risk children of well-characterized parents with BD have demonstrated that BD most often debuts as a depressive episode in mid to late adolescence and that activated episodes are rare prior to age 12 years. Some children manifest antecedent nonspecific psychopathology in early childhood. Therefore, as currently diagnosed, BD does not manifest as such typically until at least adolescence.

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Section: Follow-up Studies Of Clinical Samplesmentioning

confidence: 99%

Section: Follow-up Studies Of Clinical Samplesmentioning

confidence: 99%

Does Bipolar Disorder Exist in Children? A Selected Review

Duffy

2007

Can J Psychiatry

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“…For instance, two ongoing multisite, National Institute of Mental Health (NIMH) funded studies show that children and adolescents with BPD maintain a functionally impaired status characterized by a highly relapsing and remitting course , Birmaher, 2004, Geller, et al, 2006, Geller, et al, 2004. BPD is a substantial cause of psychiatric morbidity among youth including high rates of hospitalization, disruption of the family environment, and psychosocial disability (Akiskal, et al, 1985, Geller, et al, 2002a, Weller, et al, 1995, West, et al, 1996, Wozniak, et al, 1993.…”

Section: Introductionmentioning

confidence: 99%

Further evidence of an association between adolescent bipolar disorder with smoking and substance use disorders: A controlled study

Wilens

Biederman

Adamson

et al. 2008

Drug and Alcohol Dependence

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“…In a study of 115 children with bipolar disorder who were followed up annually over 8 years until they reached adulthood, Geller et al [21,89] found that low ratings of maternal warmth by children and parents predicted relapses into manic episodes and longer manic episodes. The family also had a protective influence in that children who lived with both of their parents had briefer manic episodes than children living in one-parent families.…”

Section: Family Characteristicsmentioning

confidence: 99%

Evidence-Based Treatment

古賀¹

2017

The SAGE Encyclopedia of Abnormal and Clinical Psychology

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Objective: The literature on bipolar in children and adolescents was reviewed to provide an update for clinicians. Review process: Literature of particular relevance to evidence-based practice was selected for critical review. Outcomes: An up-to-date overview of clinical features, epidemiology, prognosis, aetiology, assessment and intervention was provided. Conclusions: Bipolar disorder in children and adolescence is a relatively common, multifactorially determined and recurring problem which persists into adulthood. Psychometrically robust screening questionnaires and structured interviews facilitate reliable assessment. Multimodal chronic care programmes involving medication (notably lithium) and familyoriented psychotherapy are currently the treatment of choice. Keywords: Paediatric bipolar disorder, bipolar disorderResumen Objetivo: Se revisó la literatura sobre el trastorno bipolar en niñ os y adolescentes para ofrecer una actualizació n al médico. Proceso de revisión: Se seleccionó para una revisió n crítica la literatura que tuviera una relevancia concreta en relació n a la práctica basada en la evidencia. Resultados: Se brinda una revisió n actualizada sobre las características clínicas, la epidemiología, el pronó stico, la evaluació n y el manejo. Conclusión: El trastorno bipolar es un problema recurrente y relativamente comú n en niñ os y adolescentes, determinado a partir de mú ltiples factores, y que persiste hasta la edad adulta. La aplicació n de cuestionarios psicométricos de tamizaje y de entrevistas estructuradas permite una evaluació n confiable. El tratamiento de elecció n son los programas multimodales de cuidado cró nico, que incluyen el uso de medicamentos (particularmente litio) y psicoterapia orientada a la familia.

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Two-Year Prospective Follow-Up of Children With a Prepubertal and Early Adolescent Bipolar Disorder Phenotype

Cited by 276 publications

References 39 publications

Does Bipolar Disorder Exist in Children? A Selected Review

Does Bipolar Disorder Exist in Children? A Selected Review

Further evidence of an association between adolescent bipolar disorder with smoking and substance use disorders: A controlled study

Evidence-Based Treatment

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