Two weeks of watermelon juice supplementation improves nitric oxide bioavailability but not endurance exercise performance in humans

Bailey, Stephen J.; Blackwell, Jamie R.; Williams, Ewan R; Vanhatalo, Anni; Wylie, Lee J.; Winyard, Paul G.; Jones, Andrew M.

doi:10.1016/j.niox.2016.06.008

Cited by 72 publications

(77 citation statements)

References 56 publications

(90 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Interestingly, in our study, participants supplemented with CWJ showed no significant decrease in jump heights while under PLA beverage the reduction in the performance was significant. Bailey et al also found over the first 10 s that the all-out effort was higher in the watermelon juice condition [21]. These findings suggest that the athletes supplemented with CWJ may perform the race with a higher intensity and with less fatigue improving their time race.…”

Section: Discussionmentioning

confidence: 86%

“…On the other hand, Hickner et al found an improvement in time to exhaustion, during an aerobic incremental test, after a dose of 3 or 9 g of l -citrulline in active subjects [22]. In the test protocol used in this study [21], each subject ran for approximately 15 min on a motorised treadmill while the speed and the grade increased until athletes could no longer continue. In addition, citrulline or citrulline malate as supplements to increase NO production do not act as stimulants and not affect HR during exercise [4].…”

Section: Discussionmentioning

confidence: 98%

“…Although the aerobic performance was analysed in the study of Cutrufello et al [20], must be taken into account that the subjects performed a Bruce test with ~ 10 min of time trial. Bailey et al also reported that volunteers did not improve time-to-exhaustion during severe-intensity exercise (a ramp incremental cycle test on an electronically-braked cycle ergometer) after receiving 16 days of supplementation with 300 mL day −1 of a watermelon juice concentrate (∼3.4 g l -citrulline day −1 ) [21]. On the other hand, Hickner et al found an improvement in time to exhaustion, during an aerobic incremental test, after a dose of 3 or 9 g of l -citrulline in active subjects [22].…”

Section: Discussionmentioning

confidence: 99%

“…For example, Cutrufello et al showed no changes in aerobic performance and physiological variables in laboratory conditions after a single dose of l -citrulline (6 g) or watermelon juice (~ 1.0 g l -citrulline) as a pre-exercise supplement in healthy male subjects [20]. In addition, Bailey et al observed no improvement in time to exhaustion during severe-intensity exercise after 16 days of watermelon juice supplementation (3.4 g of l -citrulline per day) [21]. However, Hickner et al found an increase in aerobic performance with a reduction in treadmill test time when 9 g of l -citrulline were ingested 24 h before testing in healthy male subjects under laboratory conditions [22].…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Biochemical, physiological, and performance response of a functional watermelon juice enriched in L-citrulline during a half-marathon race

Martínez-Sánchez

Ramos-Campo

Fernández-Lobato

et al. 2017

Food & Nutrition Research

View full text Add to dashboard Cite

Background: Watermelon is a rich natural source of l-citrulline. This non-essential amino acid increases exercise performance.Objective: Evaluate the effect of Fashion watermelon juice enriched in l-citrulline (CWJ) (3.45 g per 500 mL) in physical performance and biochemical markers after a half-marathon race.Design: A randomised, double blind, crossover design where 2 h after drinking 500 mL of CWJ or placebo (PLA, beverage without l-citrulline) amateur male runners performed two half-marathon races. Jump height, heart rate and rating of perceived exertion were evaluated before and after the races. Moreover, muscle soreness and plasma markers of muscle damage and metabolism were evaluated for 72 h after the races.Results: Muscle soreness perception was significantly lower from 24 to 72 h after the race with CWJ beverage. Immediately after the races, runners under CWJ condition showed plasma lactate and glucose concentrations significantly lower and higher lactate dehydrogenase and l-arginine concentration than runners under PLA. A maintenance of jump heights after the races under CWJ supplementation was found, decreasing significantly with PLA.Conclusion: A single Fashion watermelon juice enriched in l-citrulline dose diminished muscle soreness perception from 24 to 72 h after the race and maintained lower concentrations of plasma lactate after an exhausting exercise.

show abstract

Section: Discussionmentioning

confidence: 86%

Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Biochemical, physiological, and performance response of a functional watermelon juice enriched in L-citrulline during a half-marathon race

Martínez-Sánchez

Ramos-Campo

Fernández-Lobato

et al. 2017

Food & Nutrition Research

View full text Add to dashboard Cite

show abstract

“…Findings by Collins et al [29] proved that plasma L-arginine concentration increased by 95.2 ± 3.5 μ M and 108.0 ± 4.1 μ M compared to normal plasma baseline, 86.4 ± 3.5 μ M after 3 weeks of consumption of 780 mL (~1 g L-citrulline/day) to 1560 mL (~2 g L-citrulline/day) of watermelon juices. Recently, a study by Bailey et al [30] supported the notion of the increased plasma L-arginine concentration by 116 ± 9 μ M compared to placebo, 67 ± 13 μ M after 2 weeks of 300 mL/day watermelon juice consumption, which contains ~3.4 g L-citrulline/day. L-citrulline content in crude flesh and rind extract of red watermelon and yellow crimson watermelon varied in the range of 13.91–24.99 mg/g, while L-arginine content was in the range of 4.08–8.41 mg/g.…”

Section: Resultsmentioning

confidence: 99%

Development of Isocratic RP-HPLC Method for Separation and Quantification of L-Citrulline and L-Arginine in Watermelons

Ridwan

Razak

Adenan

et al. 2018

International Journal of Analytical Chemistry

View full text Add to dashboard Cite

Watermelons (Citrullus lanatus) are known to have sufficient amino acid content. In this study, watermelons grown and consumed in Malaysia were investigated for their amino acid content, L-citrulline and L-arginine, by the isocratic RP-HPLC method. Flesh and rind watermelons were juiced, and freeze-dried samples were used for separation and quantification of L-citrulline and L-arginine. Three different mobile phases, 0.7% H3P04, 0.1% H3P04, and 0.7% H3P04 : ACN (90 : 10), were tested on two different columns using Zorbax Eclipse XDB-C18 and Gemini C18 with a flow rate of 0.5 mL/min and a detection wavelength at 195 nm. Efficient separation with reproducible resolution of L-citrulline and L-arginine was achieved using 0.1% H3P04 on the Gemini C18 column. The method was validated and good linearity of L-citrulline and L-arginine was obtained with R2 = 0.9956, y = 0.1664x + 2.4142 and R2 = 0.9912, y = 0.4100x + 3.4850, respectively. L-citrulline content showed the highest concentration in red watermelon of flesh and rind juice extract (43.81 mg/g and 45.02 mg/g), whereas L-arginine concentration was lower than L-citrulline, ranging from 3.39 to 11.14 mg/g. The isocratic RP-HPLC method with 0.1% H3P04 on the Gemini C18 column proved to be efficient for separation and quantification of L-citrulline and L-arginine in watermelons.

show abstract

The influence of different concentrations of flavanol chocolate bars under acute supplement conditions on exercise and performance

Patel¹,

Brouner

Allgrove

et al. 2020

Eur J Appl Physiol

View full text Add to dashboard Cite

Objective: The purpose of this study was to assess the effects an acute dosage of different flavanol concentrations in a dark chocolate bar has on physiological parameters during steady state (SS) and incremental exercise. Methods:In a double-blind, randomised, crossover study, fifteen healthy participants with a mean ± SD age of 30 ± 7 years; stature 176.8 ± 8.6 cm and body mass 80.3 ± 8.4 kg supplemented with high flavanol (HF) (1060mg), moderate flavanol (MF) (746mg), low flavanol (LF) (406mg) or a control (CON) (88mg) chocolate bar (~34 grams), 2 hours prior to 40 minutes of SS cycling (80% gas exchange threshold) followed by an incremental test to volitional fatigue. During the SS cycle oxygen consumption (̇2), respiratory exchange ratio (RER) and heart rate (HR) were continuously monitored. Plasma samples were collected prior to commencing exercise to determine nitrate (NO 3 -) and nitrite (NO 2 -) levels under each condition.Results: There was no observed effect between flavanol concentrations on ̇2 , RER and HR during SS cycling (P>0.05). ̇2, peak power, HR peak and RER peak also did not significantly differ between conditions (P>0.05). There was a small trend for higher plasma NO 2 -levels following higher flavanol concentration, however this did not reach statistical significance (P>0.05). Conclusion:Acute supplementation with cocoa of differing flavanol concentrations does not appear to have any effect on exercise and performance. It is plausible that longer flavanol supplementation periods might have greater accumulative effects and thus may potentially elicit a larger effect.

show abstract

Two weeks of watermelon juice supplementation improves nitric oxide bioavailability but not endurance exercise performance in humans

Cited by 72 publications

References 56 publications

Biochemical, physiological, and performance response of a functional watermelon juice enriched in L-citrulline during a half-marathon race

Biochemical, physiological, and performance response of a functional watermelon juice enriched in L-citrulline during a half-marathon race

Development of Isocratic RP-HPLC Method for Separation and Quantification of L-Citrulline and L-Arginine in Watermelons

The influence of different concentrations of flavanol chocolate bars under acute supplement conditions on exercise and performance

Contact Info

Product

Resources

About