Two weeks of metformin improves clomiphene citrate-induced ovulation and metabolic profiles in women with polycystic ovary syndrome

Insulin sensitizing agent improves clinical pregnancy rate and insulin resistant parameters in polycystic ovarian syndrome patients with acanthosis nigricans: a randomized controlled study

“…19 Our results were in agreement with data published by Khorram et al who concluded that adding metformin with CC reduced serum insulin, insulin resistance and increased SHBG levels, resulting in an improved response to CC. 20 Ben Ayed and colleagues support our results because they found a significant improvement of the ovulatory response to clomiphene citrate in PCOS women when adding metformin. 21 The same results were also observed by Dasari et al who reported that the ovulatory rate and the pregnancy rate with the metformin-CC combination was higher when compared with CC alone.…”

RETRACTED: Effect of metformin pretreatment on pregnancy outcome of in vitro matured oocytes retrieved from women with polycystic ovary syndrome

“…In addition, Genazzani et al (10) demonstrated that LH spontaneous episodic secretion was significantly modified and reproductive axis functioning was improved after 6 months metformin therapy in a group of nonobese PCOS patients. Furthermore, metformin administration has been shown to improve ovarian response to exogenous gonadotropin in women with CC-resistant PCOS (6,8). It also has been reported that the dosage of gonadotropins administrated was reduced and a higher pregnancy outcome was achieved by the administration of metformin (11).…”

“…Hence, metformin seems to be a perfect drug to treat patients with PCOS, including those with CC resistance. It was reported that metformin treatment for patients with PCOS improves a patient's menstrual cycle and increases the sensitivity for the ovulation induction drug reaction, especially in women with CC-resistant PCOS (6)(7)(8).…”

Usefulness of Bezafibrate for Ovulation Induction in Clomiphene Citrate-Resistant Polycystic Ovary Syndrome Patients with Dyslipidemia: A Prospective Pilot Study of Seven Cases

“…Recently, Hwu et al [46] reported that pretreatment with metformin for 12 days followed by its combination with CC improved ovulation and pregnancy rates compared with CC treatment alone in CC-resistant PCOS patients. Moreover, Khorram et al [47] reported that pretreatment with metformin for 2 weeks followed by its combination with CC improved the ovulation rate compared with CC treatment alone. On the other hand, Ota et al [16] reported that 4 of 7 CC-resistant PCOS patients succeeded in ovulating and becoming pregnant after pretreatment with pioglitazone for 2 weeks followed by its combination with CC.…”