Two weeks of buspirone protects against posthypoxic ventilatory pauses in the C57BL/6J mouse strain

Moore, Michael W.; Chai, Sam; Gillombardo, Carl B.; Carlo, Andrew D.; Donovan, Lucas M.; Netzer, Nikolaus C.; Strohl, Kingman P.

doi:10.1016/j.resp.2012.05.001

Cited by 19 publications

(17 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…C57BL6 mice have been used extensively to study the effects of HX, HC and H-H gas challenges on ventilatory function (see Palmer et al, 2013a,b, 2014; Gaston et al, 2014) and disordered breathing (Han et al, 2001, 2002; Tagaito et al, 2001; Schneider et al, 2003; Yamauchi et al, 2007, 2008a, 2012; Moore et al, 2012, 2014). Although Swiss-Webster mice have been used in studies concerned with the effects of 2 min episodes of HX and HC challenges on ventilatory parameters (Schenkler et al, 2002) and the effects of 5 min episodes of hypoxia-induced gasping (Jacobi and Thach, 1989), no studies have addressed the relationships between ventilatory performance and level of disordered breathing at rest, during HX or HC challenges, and upon return to room-air.…”

Section: Discussionmentioning

confidence: 99%

“…The genetic bases for sleep disordered breathing in mouse strains have received extensive investigation (Tankersley et al, 1994, 1998, 2000, Tankersley, 2000, 2001, 2003; Han and Strohl, 2000; Han et al, 2001, 2002; Tagaito et al, 2001; Schneider et al, 2003; Strohl, 2003; Tankersley and Broman, 2004; Balbir et al, 2006; Yamauchi et al, 2008b; Gillombardo et al, 2012) as have the neurochemical processes (Tankersley et al, 2002b; Price et al, 2003; Groeben et al, 2005; Yamauchi et al, 2007, 2008a, 2012; Moore et al, 2012, 2014), and structural features of respiratory structures such as the carotid bodies (Yamaguchi et al, 2003, 2006; Chai et al, 2011). …”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Enhanced non-eupneic breathing following hypoxic, hypercapnic or hypoxic–hypercapnic gas challenges in conscious mice

Getsy¹,

Davis²,

Coffee³

et al. 2014

Respiratory Physiology & Neurobiology

View full text Add to dashboard Cite

C57BL6 mice display non-eupneic breathing and spontaneous apneas during wakefulness and sleep as well as markedly disordered breathing following cessation of a hypoxic challenge. We examined whether (1) C57BL6 mice display marked non-eupneic breathing following hypercapnic or hypoxic-hypercapnic challenges, and (2) compared the post-hypoxia changes in non-eupneic breathing of C57BL6 mice to those of B6AF1 (57BL6 dam × A/J sire) and Swiss-Webster mice, which display different ventilatory responses than C57BL6 mice. C57BL6 mice displayed marked increases in respiratory frequency and non-eupneic breathing upon return to room-air after hypoxic (10% O2, 90% N2), hypercapnic (5% CO2, 21% O2, 74% N2) and hypoxic-hypercapnic (10% O2, 5% CO2, 85% N2) challenges. B6AF1 mice displayed less tachypnea and reduced non-eupneic breathing post-hypoxia, whereas Swiss-Webster mice displayed robust tachypnea with minimal increases in non-eupneic breathing post-hypoxia. These studies demonstrate that non-eupneic breathing increases after physiologically-relevant hypoxic-hypercapnic challenge in C57BL6 mice and suggest that further studies with these and B6AF1 and Swiss-Webster mice will help define the genetics of non-eupneic breathing.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Enhanced non-eupneic breathing following hypoxic, hypercapnic or hypoxic–hypercapnic gas challenges in conscious mice

Getsy¹,

Davis²,

Coffee³

et al. 2014

Respiratory Physiology & Neurobiology

View full text Add to dashboard Cite

show abstract

“…Variations of pressure in the chamber are recorded as voltage swings by the transducer output, and were entered for data analyses using Lab View 7.1 (National Instruments, Austin, TX ). The output was analyzed and scored using a customized program (Breath Detect using LabView programming by Innovative Computer Engineering, Cleveland, OH)(Moore et al, 2012). The program identifies an individual breath according to the crest and trough of the transducer’s voltage output, but the investigator visually verifies the result.…”

Section: Methodsmentioning

confidence: 99%

Effects of orexin 2 receptor activation on apnea in the C57BL/6J mouse

Moore

Akladious

et al. 2014

Respiratory Physiology & Neurobiology

View full text Add to dashboard Cite

Background The hypothesis was that an orexin 2 receptor (OX2R) agonist would prevent sleep-related disordered breathing. Methods In C57BL/6J (B6) mice, body plethysmography was performed with and without EEG monitoring of state (wakefulness, NREM and REM sleep). Outcome was apnea rate/hr during sleep-wake states at baseline and with an intracerebroventricular administration of vehicle, 4nMol of agonist OBDL, and 4nMol of an antagonist, TCS OX2 29. Results A significant reduction (p=0.035; f=2.99) in apneas/hour occurred, especially with the agonist. Expressed as a function of the change from baseline, there was a significant difference among groups in Wake (p=0.03, f=3.8), NREM (p=0.003, f= 6.98) and REM (p=0.03, f= 3.92) with the agonist reducing the rate of apneas during sleep from 29.7± 4.7 (M+/− SEM) to 7.3±2.4 during sleep (p=0.001). There was also a reduction in apneas during wakefulness. Administration of the antagonist did not increase event rate over baseline levels. Conclusions The B6 mouse is a preclinical model of wake-and sleep-disordered breathing, and the orexin receptor agonist at a dose of 4nMol given intracerebroventricularly will reduce events in sleep and also wakefulness.

show abstract

“…However, intracerebroventricular antagonism of α 2 -adrenoreceptors does not prevent STD (53), suggesting that α 2 -adrenoreceptors are not required but rather modulate the response (13). Serotonin (5-HT), also appears to be involved in STD since antagonism of 5-HT 2A/C receptors augments STD in rats (188), and antagonism of 5-HT 1A receptors is required to reveal the occurrence of STD in mice (267) (Fig. 4).…”

Section: Physiological and Molecular Responses To Brief Hypoxic Exposmentioning

confidence: 99%

“…However, researchers have since identified this mechanism in conscious rats and mice (55, 267) and also in awake humans (377). Additionally, this time domain of the HVR is sensitive to genetic differences, as indicated by the observation that the magnitude of STD can differ between strains of rats and also within substrains (144, 215, 379).…”

Section: Physiological and Molecular Responses To Brief Hypoxic Exposmentioning

confidence: 99%

Time Domains of the Hypoxic Ventilatory Response and Their Molecular Basis

Pamenter

Powell

2016

Comprehensive Physiology

104

101

View full text Add to dashboard Cite

Ventilatory responses to hypoxia vary widely depending on the pattern and length of hypoxic exposure. Acute, prolonged, or intermittent hypoxic episodes can increase or decrease breathing for seconds to years, both during the hypoxic stimulus, and also after its removal. These myriad effects are the result of a complicated web of molecular interactions that underlie plasticity in the respiratory control reflex circuits and ultimately control the physiology of breathing in hypoxia. Since the time domains of the physiological hypoxic ventilatory response (HVR) were identified, considerable research effort has gone toward elucidating the underlying molecular mechanisms that mediate these varied responses. This research has begun to describe complicated and plastic interactions in the relay circuits between the peripheral chemoreceptors and the ventilatory control circuits within the central nervous system. Intriguingly, many of these molecular pathways seem to share key components between the different time domains, suggesting that varied physiological HVRs are the result of specific modifications to overlapping pathways. This review highlights what has been discovered regarding the cell and molecular level control of the time domains of the HVR, and highlights key areas where further research is required. Understanding the molecular control of ventilation in hypoxia has important implications for basic physiology and is emerging as an important component of several clinical fields.

show abstract

Two weeks of buspirone protects against posthypoxic ventilatory pauses in the C57BL/6J mouse strain

Cited by 19 publications

References 15 publications

Enhanced non-eupneic breathing following hypoxic, hypercapnic or hypoxic–hypercapnic gas challenges in conscious mice

Enhanced non-eupneic breathing following hypoxic, hypercapnic or hypoxic–hypercapnic gas challenges in conscious mice

Effects of orexin 2 receptor activation on apnea in the C57BL/6J mouse

Time Domains of the Hypoxic Ventilatory Response and Their Molecular Basis

Contact Info

Product

Resources

About