Two‐week interval optical coherence tomography: Imaging evidence on neointimal coverage completion after implantation of the endeavor zotarolimus‐eluting stent

Abstract

The full circumferential coverage of the vessel wall by the high-signal neointima was found at as early as week 10 after E-ZES implantation, imparting a surrogate index for vascular healing by NIC.

Is Bare-Metal Stent Implantation Still Justifiable in High Bleeding Risk Patients Undergoing Percutaneous Coronary Intervention?

“…The ethics loaded with zotarolimus at the dose concentration of 10-mg/mm stent length. The drug is eluted within 15 days of implantation, and concentration within surrounding vascular tissue is not detected already at 30 days after stent deployment (8,9).…”

“…The zotarolimus-eluting Endeavor Sprint stent (E-ZES) is a hydrophilic polymer-based secondgeneration device with a unique drug fast-release profile (8), resulting in less powerful inhibition of intimal hyperplasia, but also in a rapid and/or complete stent strut coverage. This characteristic raises the possibility that it might be feasible to shorten DAPT duration while maintaining superior efficacy compared with BMS (9). The ZEUS (Zotarolimus-Eluting Endeavor Sprint Stent in Uncertain DES Candidates) study, which mandated a tailored DAPT duration based on patients' characteristics, showed a lower incidence of major adverse cardiovascular events (MACE) after E-ZES as compared with BMS in uncertain DES recipients.…”

Healing and stent coverage with the new ultrathin sirolimus‐eluting stent with abluminal biodegradable polymer

“…Proper neointimal formation and a lower number of uncovered struts are indicators optimal healing. Previous studies have shown that excessive inhibition of neointimal formation may lead to incomplete endothelialization and an increased proportion of uncovered struts, which could result in late stent thrombosis 28 . Finn et al reported that numerous uncovered struts could activate platelets, posing a significant risk for developing stent thrombosis at later stages 27 .…”

“…of uncovered struts, which could result in late stent thrombosis 28. Finn et al reported that numerous uncovered struts could activate platelets, posing a significant risk for developing stent thrombosis at later stages 27.…”

Healing and early stent coverage after ultrathin strut biodegradable polymer‐coated sirolimus‐eluting stent implantation: SiBi optical coherence tomography study

“…This optimum healing has been measured in terms of apt neointimal formation and lower number of uncovered struts. Previous studies show that excessive inhibition of neointimal formation could cause incomplete endothelialization, which is associated with increased proportion of uncovered struts and the subsequent occurrence of late stent thrombosis 27 . Finn et al reported that a large proportion of uncovered struts have potential to activate platelets, resulting to be major risk factor for developing stent thrombosis at later stages 26 .…”