Two-Week Combination Chemotherapy with Gemcitabine, High-Dose Folinic Acid and 5 Fluorouracil (GEMFUFOL) as First-Line Treatment of Metastatic Biliary Tract Cancers

Background: Because of the relative rarity of biliary tract cancers (BTCs), defining long term survival results is difficult. In the present study, we aimed to evaluate the survival of a series of cases in Turkey. Materials and Methods: A totally of 47 patients with billiary tract cancer from Mersin Goverment Hospital, Acıbadem Kayseri Hospital and Kayseri Training and Research Hospital were analyzed retrospectively using hospital records between 2006-2012. Results: The median overall survival was 19.3±3.9 months for all patients. The median disease free and overall survivals were 24.3±5.3 and 44.1±12.9 months in patients in which radical surgery was performed , but in those with with inoperable disease they were only 5.3±1.5 and 10.7±3.2 months, respectively. Conclusions: BTCs have a poor prognosis. Surgery with a microscopic negative margin is still the only curative treatment.

Section: Discussionsupporting

confidence: 83%

Survival Analysis of Biliary Tract Cancer Cases in Turkey

Akca

Mutlu²,

Erden³

et al. 2014

“…Recently, several studies (Unal et al, 2013;Hakim et al, 2014) have discussed the combinational effect of 5-FU with other agents, they found that the combination chemotherapy of Gemcitabine, Folinic Acid and 5-FU has a more obvious anti-cancer effect but as well as toxicity. So the combination of a natural, low-toxicity and highefficacy agents with 5-FU may be better.…”

Section: Suppressive Effect Of Sinomenine Combined With 5-fluorouracimentioning

confidence: 99%

Suppressive Effect of Sinomenine Combined with 5-Fluorouracil on Colon Carcinoma Cell Growth

Zhang¹,

Yang²,

Wu³

et al. 2014

Asian Pac J Cancer Prev, 15 (16), 6737-6743 IntroductionColorectal cancer is the fourth most common cancer in the world, and significant international variations in the distribution of colorectal cancer have been observed (Center et al., 2009;Siegal et al., 2013). Meanwhile, colon cancer is more frequent than rectal cancer (Labianca et al., 2010;Di Lena et al., 2013). Recently, the main therapy on primary colon carcinoma is surgical resection, but only half of them can be cured with the rest hopeless. In addition, before the colon carcinoma was diagnosed successfully, the metastasis has already happened. For better prognosis after surgical resection or other clinical situations, chemotherapy as a relatively effective therapy is used more and more.As the first-line chemotherapeutic agent to treat colon carcinoma, 5-fluorouracil (5-FU) has past 40 years (Beretta et al., 2004). Whereas the uncontrollable toxicity and dissatisfying effective rate which around 20-35% with median overall survival no more than 1 year could not meet the needs of treatment (Wu et al., 2013;Focan et al., 2013;Ghiringhelli et al., 2013). So to seek a way such as united therapy that can improve the effective rate and decrease

“…Fever in tumor patients, which will cause a steady deterioration due to increased depletion, is common because of long-term chemoradiotherapy and suppressed immunity (Canyilmaz et al, 2013;Engin et al, 2013;Unal et al, 2013;Wang et al, 2013). Thus, a fast and accurate test is specially needed for defining the etiology of FUO.…”

Section: Discussionmentioning

confidence: 99%

Clinical Value of Dual-phase¹⁸F-FDG SPECT with Serum Procalcitonin for Identification of Etiology in Tumor Patients with Fever of Unknown Origin

Zhang

Shan²,

Wu³

et al. 2014