Two waves and a high tide: the COVID-19 epidemic in France

Sofonea, Mircea T.; Boennec, Corentin; Michalakis, Yannis; Alizon, Samuel

doi:10.1016/j.accpm.2021.100881

Cited by 7 publications

(6 citation statements)

References 13 publications

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“…In conclusion, given the progressive lifting of the control measures in June 2021 in France [18], these results call for particular care regarding vaccination rollout and the maintenance of non-pharmaceutical prevention until vaccine coverage reaches levels compatible with spontaneous regression of the epidemic.…”

Section: Discussionmentioning

confidence: 98%

“…First, although we performed sequencing to distinguish between B.1.351 and P.1 lineages, in some samples collected in March and, to a lesser extent, April, further sequencing will be needed to validate our assumption that the transmission advantage belongs to B.1.351, to P.1, or to both. Second, France had entered a third national lockdown on 3 April, which means that most of the tests analysed here were performed in a declining epidemic [18]. If what we assume to be the B.1.351 lineage causes infections that have a shorter generation interval than the B.1.1.7 lineage, this could affect the transmission advantage estimates.…”

Section: Discussionmentioning

confidence: 99%

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The SARS-CoV-2 B.1.351 lineage (VOC β) is outgrowing the B.1.1.7 lineage (VOC α) in some French regions in April 2021

et al. 2021

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To assess SARS-CoV-2 variants spread, we analysed 36,590 variant-specific reverse-transcription-PCR tests performed on samples from 12 April–7 May 2021 in France. In this period, contrarily to January–March 2021, variants of concern (VOC) β (B.1.351 lineage) and/or γ (P.1 lineage) had a significant transmission advantage over VOC α (B.1.1.7 lineage) in Île-de-France (15.8%; 95% confidence interval (CI): 15.5–16.2) and Hauts-de-France (17.3%; 95% CI: 15.9–18.7) regions. This is consistent with VOC β’s immune evasion abilities and high proportions of prior-SARS-CoV-2-infected persons in these regions.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

The SARS-CoV-2 B.1.351 lineage (VOC β) is outgrowing the B.1.1.7 lineage (VOC α) in some French regions in April 2021

et al. 2021

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“…During the first coronavirus disease 2019 (COVID-19) wave (March-May 2020), intensive care units (ICU) in many areas of Europe were overwhelmed by patients developing severe hypoxemic pneumonia and acute respiratory distress syndrome (ARDS) [ 1 – 3 ]. To manage this major public health problem, various countries opened temporary hospitals by transforming exhibition centres: IFEMA (Institución Ferial de Madrid) in Madrid, Spain, Fiera in Milano, Italy, Corona Hospital in Berlin, Germany, and Nightingale Hospitals in several cities in the United Kingdom [ 4 – 6 ].…”

Section: Introductionmentioning

confidence: 99%

Temporary ICUs during the COVID-19 pandemic first wave: description of the cohort at a French centre

et al. 2022

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Background During the COVID-19 first wave in France, the capacity of intensive care unit (ICU) beds almost doubled, mainly because of the opening of temporary ICUs with staff and equipment from anaesthesia. Objectives We aim to investigate if the initial management in temporary ICU is associated with a change in ICU mortality and short-term prognosis. Design Retrospective single-centre cohort study. Setting Surgical ICU of the Bichat Claude Bernard University Hospital during the COVID-19 “first wave” (from 18 March to 10 April 2020). Patients All consecutive patients older than 18 years of age with laboratory-confirmed SARS-CoV-2 infection and/or typical radiological patterns were included during their first stay in the ICU for COVID-19. Intervention Patients were admitted to a temporary ICU if no room was available in the classical ICU and if they needed invasive mechanical ventilation but no renal replacement therapy or Extracorporeal Membrane Oxygenation (ECMO) in the short term. The temporary ICUs were managed by mixed teams (from the ICU and anaesthesiology departments) following a common protocol and staff meetings. Main outcome measure ICU mortality Results Among the 59 patients admitted, 37 (62.7%) patients had initial management in the temporary ICU. They had the same characteristics on admission and the same medical management as patients admitted to the classical ICU. ICU mortality was similar in the 2 groups (32.4% in temporary ICUs versus 40.9% in classical ICUs; p=0.58). SAPS-II and ECMO use were associated with mortality in multivariate analysis but not admission to the temporary ICU. Conclusion In an overload context of the ICU of a geographical area, our temporary ICU model allowed access to intensive care for all patients requiring it without endangering them.

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“…When projections overlap, the former projections are depicted in lighter color. Only the main projections publicly released (in [9] , [16] , the French media, or on social networks) are here shown and no simulation was performed more than a day after that of the last available data point. The blue arrows shows the duration the current projection accurately anticipates the ICU dynamics within the range of the simulations.…”

mentioning

confidence: 99%

“…Let us focus on the projections published in the previous issue of Anaesthesia Critical Care and Pain Medicine [9] . These investigated the end of the third lockdown, which was initiated on the 3rd of April 2021 (with a tolerance until the 5th due to the Easter weekend) and released in several stages three weeks later.…”

mentioning

confidence: 99%

Anticipating COVID-19 intensive care unit capacity strain: A look back at epidemiological projections in France

Sofonea

Alizon

2021

Anaesthesia Critical Care & Pain Medicine

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Two waves and a high tide: the COVID-19 epidemic in France

Cited by 7 publications

References 13 publications

The SARS-CoV-2 B.1.351 lineage (VOC β) is outgrowing the B.1.1.7 lineage (VOC α) in some French regions in April 2021

The SARS-CoV-2 B.1.351 lineage (VOC β) is outgrowing the B.1.1.7 lineage (VOC α) in some French regions in April 2021

Temporary ICUs during the COVID-19 pandemic first wave: description of the cohort at a French centre

Anticipating COVID-19 intensive care unit capacity strain: A look back at epidemiological projections in France

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