Two-wavelength carbon dioxide laser application for in-vitro blood glucose measurements

Meinke, Martina C.; Müller, G.; Albrecht, Hans-Jörg; Antoniou, Christina; Richter, Heike; Lademann, Jürgen

doi:10.1117/1.2870093

Cited by 13 publications

(5 citation statements)

References 14 publications

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“…As an example, the aforementioned technique was utilized to detect the glucose concentration in whole blood. 280 Interestingly, Brandstetter et al developed a compact, portable prototype with a semi-automated mid-infrared (MIR) absorption sensor system based on a spectrally tunable, monochromatic, MIR external cavity quantum cascade laser (QCL) 281 for clinical applications. Figure 12 shows the schematic workflow of the MIR-based QCL system.…”

Section: Ir Spectroscopy For Detection Of Selected Analytesmentioning

confidence: 99%

Infrared Spectroscopy of Blood

et al. 2021

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The magnitude of infectious diseases in the twenty-first century created an urgent need for point-of-care diagnostics. Critical shortages in reagents and testing kits have had a large impact on the ability to test patients with a suspected parasitic, bacteria, fungal, and viral infections. New point-of-care tests need to be highly sensitive, specific, and easy to use and provide results in rapid time. Infrared spectroscopy, coupled to multivariate and machine learning algorithms, has the potential to meet this unmet demand requiring minimal sample preparation to detect both pathogenic infectious agents and chronic disease markers in blood. This focal point article will highlight the application of Fourier transform infrared spectroscopy to detect disease markers in blood focusing principally on parasites, bacteria, viruses, cancer markers, and important analytes indicative of disease. Methodologies and state-of-the-art approaches will be reported and potential confounding variables in blood analysis identified. The article provides an up to date review of the literature on blood diagnosis using infrared spectroscopy highlighting the recent advances in this burgeoning field.

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Section: Ir Spectroscopy For Detection Of Selected Analytesmentioning

confidence: 99%

Infrared Spectroscopy of Blood

et al. 2021

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“…The ratio of both wavelengths is determined, which correlates well with the glucose concentration in whole blood samples. The strong linear correlation (R 2 = 0.997) has been obtained with a glucose concentration in the range of 40-400 mg/dl [1].…”

Section: Two-wavelength Co2 Laser For Determining the Glucose Concent...mentioning

confidence: 72%

“…Application of non-invasive methods is advantageous and currently popular in in vivo skin research. This concerns, but is not limited to the determination of the glucose concentration in blood samples using attenuated total reflection Fouriertransform infrared (ATR-FTIR) spectroscopy [1,2] as well as the analysis of the influence of topically applied substances on the blood flow using laser Doppler flowmetry [3][4][5]. Antioxidants like carotenoids betacarotene and lycopene could be detected in the blood plasma correlating to the antioxidant status of human skin and reflecting health conditions in animals [6].…”

Section: Introductionmentioning

confidence: 99%

Correlation between Blood Flow and Various Physiological Parameters in Human Skin

Lademann

Darvin

Meinke

et al. 2022

J-BPE

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Blood flow is an important parameter of the human organism and skin physiology. It correlates with skin temperature, penetration of active substances through the skin, delivery of antioxidants and development of disease symptoms, especially during inflammatory processes. Dr. Alexander Vasilyevich Priezzhev played a major role in the investigation of blood circulation, cell aggregation and disease correlation, as well as in the development of an aggregometer to determine the rheology of human blood flow. The following article provides an overview of the work performed at the

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“…According to reports showing the quantification of glucose in serum, plasma and blood by means of FTIR spectroscopy , we chose the IR bands at 1033 and 1079 cm −1 as glucose markers, and an increase in their intensity in diabetes is clearly visible in the insets in Figure A,B. The spectral region of 1200 to 950 cm −1 is also specific for carbohydrates; however, absorbances of bands present in this range do not change in the way observed for 1033 and 1079 cm −1 maxima.…”

Section: Resultsmentioning

confidence: 99%

A possible Fourier transform infrared‐based plasma fingerprint of angiotensin‐converting enzyme inhibitor‐induced reversal of endothelial dysfunction in diabetic mice

Staniszewska-Slezak

Wiercigroch

Fedorowicz

et al. 2017

Journal of Biophotonics

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Angiotensin-converting enzyme inhibitors (ACE-I) display vasoprotective activity and represent the cornerstone in the treatment of cardiovascular diseases. In this study, we tested whether Fourier transform infrared (FTIR)-based analysis of blood plasma is sensitive to detect vasoprotective effects of treatment with perindopril including reversal of endothelial dysfunction in diabetes. For this purpose, plasma samples were collected from untreated db/db mice, db/db mice treated with 2 or 10 mg/kg perindopril and db+ mice. The effect of perindopril on endothelial function was examined in ex vivo aortic rings; 10 mg/kg but not 2 mg/kg of perindopril reversed endothelial dysfunction. In plasma of db/db mice, the balance between conformations of plasma proteins was noted, and treatment with perindopril at a high dose but not at a low dose reversed this effect. This was revealed by amide II/amide I ratio attributed to increased β-sheet formation. Spectral markers at 3010, 1520/1238 cm , representative for unsaturation degree of lipids and phosphorylation of tyrosine, respectively, were also affected by perindopril treatment. In conclusion, although metabolic abnormalities associated with type 2 diabetes mellitus such as hypertriglyceridemia and hyperglycemia strongly affected spectral FTIR profile of diabetic plasma, we identified FTIR features that seem to be associated with the vasoprotective activity of ACE-I.

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Two-wavelength carbon dioxide laser application for in-vitro blood glucose measurements

Cited by 13 publications

References 14 publications

Infrared Spectroscopy of Blood

Infrared Spectroscopy of Blood

Correlation between Blood Flow and Various Physiological Parameters in Human Skin

A possible Fourier transform infrared‐based plasma fingerprint of angiotensin‐converting enzyme inhibitor‐induced reversal of endothelial dysfunction in diabetic mice

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