Two unusual glycerophospholipids from a filamentous fungus, Absidia corymbifera

Batrakov, S. G.; Konova, I. V.; Шейченко, В. И.; Esipov, S. E.; Galanina, L. A.

doi:10.1016/s1388-1981(01)00082-8

Cited by 13 publications

(5 citation statements)

References 22 publications

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Section: Resultsmentioning

confidence: 99%

“…Choline is a key component involved in the synthesis of phospholipids associated with forming cell membranes, especially as incorporated through phosphatidylcholine(Li and Vance 2008). Although, in fungi and insects, phosphatidylethanolamine is also a major cell membrane component(Batrakov et al 2001;Dawaliby et al 2016;Cassilly and Reynolds 2018). Using the lipids LC-MS/MS dataset we compared peak values of phosphatidylethanolamines (n = 95 features) and phosphatidylcholines (n = 85 features)…”

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confidence: 99%

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Multiomic interpretation of fungus-infected ant metabolomes during manipulated summit disease

Will

Attardo

Bekker

2023

Preprint

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Parasitically manipulated Camponotus floridanus ants show multiple diseased behaviors and a fatal summiting phenotype when infected by Ophiocordyceps camponoti-floridani fungi. Altered host behavior as a response to and driven by parasites occur in a broad swath of taxa. In many cases, such as this interaction, the underlying mechanisms have not yet been clearly characterized. The drastic phenotypic changes observed could in some cases reflect large physiological changes within cells, spanning different molecular levels from nucleic acids to metabolites. Here, we link existing genomic and transcriptomic data to a new metabolomic dataset we produced to hypothesize on the mechanisms of manipulated "zombie ants" from a multiomic perspective. Multiple lines of evidence point toward dysregulation of neurotransmitters and neuronal signaling. We propose that these processes are altered during infection and manipulation based on: neurotransmitter synthesis and receptor gene expression, altered metabolite abundances, with plausible behavioral ties to known effects of these neurotransmitters in ants and other insects, and possible suppression of a connected immunity pathway. We additionally report signals for fungal metabolic activity during manipulation and early evidence for alterations of host processes related to detoxification, anti-stress protectants, and insect hormone metabolism.

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Section: Resultsmentioning

confidence: 99%

mentioning

confidence: 99%

Multiomic interpretation of fungus-infected ant metabolomes during manipulated summit disease

Will

Attardo

Bekker

2023

Preprint

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“…Therefore, the yields of bioconversion are always so high that they permitted the retention of huge quantity of polymeric biosurfactants for diverse applications. They can be produced by a wide diversity of bacteria (Mousavian and Rahimi 2010;Burgos-Díaz et al 2011;Franzetti et al 2012), Actinomycete (Kokare et al 2007;Maniyar et al 2011), yeast (Walencka et al 2007;Dikit et al 2010) and fungus (Batrakov et al 2001;Paraszkiewicz et al 2002;Katemai et al 2008). Generally, polymeric bioemulsifiers are released in the extracellular medium of the fermentation broth (Boyle and Reade 1983;Calvo et al 1995).…”

Section: Introductionmentioning

confidence: 99%

High molecular weight bioemulsifiers, main properties and potential environmental and biomedical applications

Mnif

Ghribi

2015

World J Microbiol Biotechnol

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High molecular weight bioemulsifiers are amphipathic polysaccharides, proteins, lipopolysaccharides, lipoproteins, or complex mixtures of these biopolymers, produced by a wide variety of microorganisms. They are characterized by highly structural diversity and have the ability to decrease the surface and interfacial tension at the surface and interface respectively and/or emulsify hydrophobic compounds. Emulsan, fatty acids, phospholipids, neutral lipids, exopolysaccharides, vesicles and fimbriae are among the most popular high molecular weight bioemulsifiers. They have great physic-chemical properties like tolerance to extreme conditions of pH, temperature and salinity, low toxicity and biodegradability. Owing their emulsion forming and breaking capacities, solubilization, mobilization and dispersion activities and their viscosity reduction activity; they possess great environmental application as enhancer of hydrocarbon biodegradation and for microbial enhanced oil recovery. Besides, they are applied in biomedical fields for their antimicrobial and anti-adhesive activities and involvement in immune responses.

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“…One of N-acylphosphatidylethanolamines, namely Nacetyl PE was allegedly found in the mammalian brain and placenta [11], but reliably confirmed only in zygomycete Absidia corymbifera [12]. Two major low polarity phospholipids based on PG structure are BPA and SLBPA ( Fig.…”

Section: Introductionmentioning

confidence: 94%

TLC and ³¹P‐NMR Analysis of Low Polarity Phospholipids

Vyssotski

MacKenzie

Scott

2008

Lipids

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High-performance TLC and (31)P-NMR were assessed as methods of observing the presence of numerous low polarity phospholipids: bis-phosphatidic acid (BPA), semi-lyso bis-phosphatidic acid (SLBPA), N-acyl phosphatidylethanolamine (NAPE), N-(1,1-dimethyl-3-oxo-butyl)-phosphatidylethanolamine (diacetone adduct of PE, DOBPE), N-acetyl PE, phosphatidylmethanol (PM), phosphatidylethanol (PEt), phosphatidyl-n-propanol (PP), phosphatidyl-n-butanol (PB). Both techniques are non-discriminative and do not require the prior isolation of individual lipids. It appears that 2D TLC is superior to (31)P NMR in the analysis of low polarity phospholipids. All phosphatidylalcohols were well separated by 2D TLC. However, some compounds which can present difficulty in separation by 2D-TLC (e.g., SLBPA and NAPE; or DOBPE and N-acetyl PE) were easily distinguished using (31)P NMR so the methods are complimentary. A disadvantage of 2D TLC is that Rf values can vary with different brands and batches of TLC plates. The chemical shifts of (31)P NMR were less variable, and so a library of standards may not be necessary for peak identification. Another advantage of (31)P NMR is the ease of quantification of phospholipids. The applicability of the methods was tested on natural extracts of fish brain and cabbage stem.

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Two unusual glycerophospholipids from a filamentous fungus, Absidia corymbifera

Cited by 13 publications

References 22 publications

Multiomic interpretation of fungus-infected ant metabolomes during manipulated summit disease

Multiomic interpretation of fungus-infected ant metabolomes during manipulated summit disease

High molecular weight bioemulsifiers, main properties and potential environmental and biomedical applications

TLC and ³¹P‐NMR Analysis of Low Polarity Phospholipids

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Two unusual glycerophospholipids from a filamentous fungus, Absidia corymbifera

Cited by 13 publications

References 22 publications

Multiomic interpretation of fungus-infected ant metabolomes during manipulated summit disease

Multiomic interpretation of fungus-infected ant metabolomes during manipulated summit disease

High molecular weight bioemulsifiers, main properties and potential environmental and biomedical applications

TLC and 31P‐NMR Analysis of Low Polarity Phospholipids

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TLC and ³¹P‐NMR Analysis of Low Polarity Phospholipids