Two unprecedented natural Aib-peptides with the (Xaa-Yaa-Aib-Pro) motif and an unusual C-terminus: structures, membrane-modifying and antibacterial properties of pseudokonins KL III and KL VI from the fungus Trichoderma pseudokoningii

Rebuffat, Sylvie; Goulard, Christophe; Hlimi, Sanae; Bodo, Bernard

doi:10.1002/1099-1387(200010)6:10<519::aid-psc273>3.0.co;2-6

Cited by 28 publications

(5 citation statements)

References 38 publications

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“…Therefore, the potential antibacterial compound produced by T. stipitatus KUC21402 is likely to be talaromyone. The genus Trichoderma is well known for producing various antibacterial compounds: 3-(3-oxocyclopent-1-enyl) propanoic acid, trichodermaol, alternariol 1′-hydroxy-9-methyl ether [105,106,107]; pseudokonin KL III and IV produced from T. pseudokoningii [108]; suzukacillin, viridian, lignoren, and gliotoxin from T. viride [109,110,111,112]; 6-n-pentyl-α-pyrone from T. harzianum and T. longibrachiatum [113]; shikimic acid from T. ovalisporum [114]; and coniothranthraquinone 1 and emodin from T. aureoviride [115]. Therefore, the potential antibacterial compounds of T. afroharzianum KUC21401 and KUC21404 are unlikely to be novel, but this is the first report on the antibacterial activity of this species.…”

Section: Resultsmentioning

confidence: 99%

Fungal Diversity in Intertidal Mudflats and Abandoned Solar Salterns as a Source for Biological Resources

et al. 2019

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Intertidal zones are unique environments that are known to be ecological hot spots. In this study, sediments were collected from mudflats and decommissioned salterns on three islands in the Yellow Sea of South Korea. The diversity analysis targeted both isolates and unculturable fungi via Illumina sequencing, and the natural recovery of the abandoned salterns was assessed. The phylogeny and bioactivities of the fungal isolates were investigated. The community analysis showed that the abandoned saltern in Yongyudo has not recovered to a mudflat, while the other salterns have almost recovered. The results suggested that a period of more than 35 years may be required to return abandoned salterns to mudflats via natural restoration. Gigasporales sp. and Umbelopsis sp. were selected as the indicators of mudflats. Among the 53 isolates, 18 appeared to be candidate novel species, and 28 exhibited bioactivity. Phoma sp., Cladosporium sphaerospermum, Penicillium sp. and Pseudeurotium bakeri, and Aspergillus urmiensis showed antioxidant, tyrosinase inhibition, antifungal, and quorum-sensing inhibition activities, respectively, which has not been reported previously. This study provides reliable fungal diversity information for mudflats and abandoned salterns and shows that they are highly valuable for bioprospecting not only for novel microorganisms but also for novel bioactive compounds.

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Section: Resultsmentioning

confidence: 99%

Fungal Diversity in Intertidal Mudflats and Abandoned Solar Salterns as a Source for Biological Resources

et al. 2019

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“…Peptaibols are a class of linear short-chain length (≤20 residues) peptides of fungal origin produced by the nonribosomal peptide synthase. The biological role of peptaibols has been demonstrated in few systems, and antimicrobial activity was reported (20,25,88,92,112). However, a growing number of reports indicate that peptaibols can elicit plant defense responses (21,36,123).…”

Section: Fungal Compounds Involved In Induction Of Plant Responsesmentioning

confidence: 99%

Induced Systemic Resistance and Plant Responses to Fungal Biocontrol Agents

Shoresh

Harman

Mastouri

2010

Annu. Rev. Phytopathol.

1,100

707

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Biocontrol fungi (BCF) are agents that control plant diseases. These include the well-known Trichoderma spp. and the recently described Sebacinales spp. They have the ability to control numerous foliar, root, and fruit pathogens and even invertebrates such as nematodes. However, this is only a subset of their abilities. We now know that they also have the ability to ameliorate a wide range of abiotic stresses, and some of them can also alleviate physiological stresses such as seed aging. They can also enhance nutrient uptake in plants and can substantially increase nitrogen use efficiency in crops. These abilities may be more important to agriculture than disease control. Some strains also have abilities to improve photosynthetic efficiency and probably respiratory activities of plants. All of these capabilities are a consequence of their abilities to reprogram plant gene expression, probably through activation of a limited number of general plant pathways.

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“…A common method for making this determination is derivatization of amino acids in the hydrolysate with N α -(2,4-dinitro-5-fluoro-phenyl)-1-L-alanine-amide (FDAA, Marfey's reagent), followed by HPLC separation and comparison of the retention times with those of derivatized standard amino acids [78]. However, classical GC/MS approaches have also been used in amino acid analysis [37,39,72]. According to the original Roepstorff nomenclature [80] which was revised by Biemann [81], six series of fragment ions can be generated during cleavage of a peptide bond, corresponding to C-heteroatom-and α-bond cleavages.…”

Section: Nomenclature Of Peptaibols and Peptaibioticsmentioning

confidence: 99%

The occurrence of peptaibols and structurally related peptaibiotics in fungi and their mass spectrometric identification via diagnostic fragment ions

Degenkolb

Berg

Gams

et al. 2003

Journal of Peptide Science

120

100

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Peptaibols and related peptide antibiotics (peptaibiotics) display diagnostically useful fragmentation patterns during mass spectrometry (FAB-MS, ESI-CID-MS/MS and CID-MS n ). The paper compiles fragmentation data of pseudo-molecular ions reported in the literature as a guide to the rational identification of recurrently isolated and new peptaibols and peptaibiotics. Taxonomic and ecological aspects of microorganisms producing peptaibols and peptaibiotics are discussed.

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Two unprecedented natural Aib-peptides with the (Xaa-Yaa-Aib-Pro) motif and an unusual C-terminus: structures, membrane-modifying and antibacterial properties of pseudokonins KL III and KL VI from the fungus Trichoderma pseudokoningii

Cited by 28 publications

References 38 publications

Fungal Diversity in Intertidal Mudflats and Abandoned Solar Salterns as a Source for Biological Resources

Fungal Diversity in Intertidal Mudflats and Abandoned Solar Salterns as a Source for Biological Resources

Induced Systemic Resistance and Plant Responses to Fungal Biocontrol Agents

The occurrence of peptaibols and structurally related peptaibiotics in fungi and their mass spectrometric identification via diagnostic fragment ions

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