1963
DOI: 10.1172/jci104773
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TWO TYPES OF Γ-Myeloma PROTEINS, Β2A-Myeloma PROTEINS, Γ1-Macroglobulins, AND BENCE JONES PROTEINS IDENTIFIED BY TWO GROUPS OF COMMON ANTIGENIC DETERMINANTS

Abstract: The serum myeloma proteins are characteristic products of malignant plasma cells, and individual myeloma proteins provide an important source of information on the protein-producing capacities (and limitations) of plasma cell clones. The globulins produced by malignant plasma cells are closely related to the normal v-globulins, but immunochemical studies of the antigenic determinants present on myeloma proteins have uniformly shown that myeloma proteins are antigenically deficient when compared to normal y-glo… Show more

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Cited by 77 publications
(20 citation statements)
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“…In a given case of multiple myeloma or macroglobulinaemia on the other hand the abnormal proteins belong invariably either to type K or type L (Mannik and Kunkel, 1962;Fahey and Solomon, 1963); this fact has been regarded as consistent with, and indicative of, the formation of the abnormal proteins by single clones of cells. The evidence therefore is that each of the present patients had monoclonal light-chain proteinaemia with consequent light-chain (Bence Jones) proteinuria.…”
Section: Discussionmentioning
confidence: 88%
See 1 more Smart Citation
“…In a given case of multiple myeloma or macroglobulinaemia on the other hand the abnormal proteins belong invariably either to type K or type L (Mannik and Kunkel, 1962;Fahey and Solomon, 1963); this fact has been regarded as consistent with, and indicative of, the formation of the abnormal proteins by single clones of cells. The evidence therefore is that each of the present patients had monoclonal light-chain proteinaemia with consequent light-chain (Bence Jones) proteinuria.…”
Section: Discussionmentioning
confidence: 88%
“…All immunoglobulins, including light-chain proteins, in normal serum and urine and in proteinuria, whether due to glomerular or tubular disease, contain type K and type L components in not greatly dissimilar proportions (Fahey and Solomon, 1963;Stevenson, 1962;Takatsuki and Osserman, 1964;Harrison, 1966). In a given case of multiple myeloma or macroglobulinaemia on the other hand the abnormal proteins belong invariably either to type K or type L (Mannik and Kunkel, 1962;Fahey and Solomon, 1963); this fact has been regarded as consistent with, and indicative of, the formation of the abnormal proteins by single clones of cells.…”
Section: Discussionmentioning
confidence: 99%
“…Measurements of the levels of Types K and L (Types I and II) showed a marked abnormality in the ratio of Type K: L (I:1) immunoglobulins in myeloma serums (Table II). This abnormal ratio is caused by the large amounts of myeloma protein that are either Type K (I) or Type L (II) (35)(36)(37)(38) and by the reduced amounts of normal immunoglobulin. The remaining immunoglobulins of the type not represented in the myeloma protein are found to be reduced (Table II).…”
Section: Resultsmentioning
confidence: 99%
“…
~AN ERYTHROCYTEAUTOANTIBODIES. I of a given patient are composed exclusively of molecules having either type I or type II L chains (7,8).This report will present evidence that populations of isolated erythrocyte autoanfibodies exhibit a strikingly high frequency of L chain homogeneity. Some of these autoantibody populations bearing only one detectable L chain type may also display relative homogeneity in electrophoretic mobility.
Materials and MethodsHuman Antibodies.--For isolation of autoantibodies, bleedings from patients 2 were taken into 0.01 M Na2EDTA or ACD solution, a Eluates from 6 times washed RBC stromata were made by acidification (14) or by heating at 60°C for 30 minutes.
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mentioning
confidence: 78%