Two triterpeniods from Cyclocarya paliurus (Batal) Iljinsk (Juglandaceae) promote glucose uptake in 3T3-L1 adipocytes: The relationship to AMPK activation

Zhu, Kuiniu; Jiang, Cuihua; Tian, Yushan; Xiao, Na; Wu, Zheng-Feng; Ma, Yonglan; Lin, Zhang; Fang, Shengzuo; Shang, Xinzhe; Liu, Kun; Zhang, J.; Liu, B.L.; Yin, Zhi Qi

doi:10.1016/j.phymed.2015.05.058

Cited by 52 publications

(30 citation statements)

References 34 publications

(19 reference statements)

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“…Moreover, HIF-1α is documented to induce NF-κB activation [25], Although the anti-inflammatory activities of metformin and resveratrol have been well documented [33,34,35] before, these results suggested that inhibition of HIF-1α…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Metformin and resveratrol ameliorate muscle insulin resistance through preventing lipolysis and inflammation in hypoxic adipose tissue

Zhao

Feng

et al. 2016

Cellular Signalling

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Section: Accepted Manuscriptmentioning

confidence: 99%

Metformin and resveratrol ameliorate muscle insulin resistance through preventing lipolysis and inflammation in hypoxic adipose tissue

Zhao

Feng

et al. 2016

Cellular Signalling

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“…Several studies showed that CPAE can improve insulin resistance by inhibiting serine phosphorylation of IRS-1, thereby restoring tyrosine phosphorylation of IRS-1 and increasing Akt phosphorylation in the muscle tissue of mice with adipose dysfunction and insulin resistance [25]. In addition, animal studies showed that CPAE can reduce food intake in high-fat-diet (HFD) and streptozotocin- (STZ-) induced type 2 diabetic rats and can lower lipid levels in hyperlipidemic mice [26, 27]. However, it is not clear whether CPAE can affect insulin signaling in the hypothalamus.…”

Section: Introductionmentioning

confidence: 99%

Cyclocarya paliurus (Batal.) Ijinskaja Aqueous Extract (CPAE) Ameliorates Obesity by Improving Insulin Signaling in the Hypothalamus of a Metabolic Syndrome Rat Model

Yoshitomi

Sun

et al. 2017

Evidence-Based Complementary and Alternative Medicine

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Background Antiobesity drugs may not be optimal for treating obesity. However novel antiobesity agents, especially those derived from natural products, may be suitable. Therefore, we investigated the effects and mechanisms of Cyclocarya paliurus (CP) aqueous extract (CPAE) on obesity. Methods SHR.Cg-Leprcp/NDmcr (SHR/cp) rats were used as a model of obesity and metabolic syndrome. Experimental animals were allocated into two groups—control and CPAE (0.5 g/kg)—for a 7-week treatment period. Examinations were performed, including general physiological characteristics, obesity-related biochemical parameters, and insulin-signaling pathway-related proteins in the hypothalamus. Results Treatment with CPAE reduced food intake, body weight, organ weight, fat mass, and body mass index (BMI) in SHR/cp rats. Meanwhile, CPAE also decreased the levels of fasting serum glucose, fasting serum insulin, HOMA-IR, serum free fatty acids, serum malondialdehyde, serum superoxide dismutase, and serum total-glutathione. The levels of phosphorylation of target proteins—including InsR, IRS1, PI3Kp85, Akt, and FoXO1 as well as protein expression of POMC—were significantly upregulated in the hypothalamus, but NPY expression remarkably decreased. Conclusions CPAE has antiobesity, antihypoglycemic, antihypolipidemic, and antioxidant properties. The mechanism responsible for the antiobesity effect of CPAE may be related to suppression of energy intake via regulation of insulin-signaling pathway in the hypothalamus.

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“…28) It is reported that regulation of AMPK is related to IRS/ PI3K pathway. 29) Since Glycoside St-E2 and St-C1 activated AMPK, it may affect insulin signal pathway.…”

Section: Discussionmentioning

confidence: 99%

Anti-adipogenic effect of Glycoside St-E2 and Glycoside St-C1 isolated from the leaves of Acanthopanax henryi (Oliv.) Harms in 3T3-L1 cells

Han

et al. 2016

Bioscience, Biotechnology, and Biochemistry

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Acanthopanax henryi (Oliv.) Harms has been used in the treatment of arthritis, rheumatism, and abdominal pain. This study evaluated whether natural compounds isolated from the leaves of A. henryi (Oliv.) Harms could inhibit adipocyte differentiation by regulating transcriptional factors such as peroxisome proliferator-activated receptor γ (PPARγ) and CCAAT/enhancer-binding protein α (C/EBPα). AMP-activated protein kinase (AMPK) activity was also evaluated. Among the several compounds isolated from the leaves of A. henryi (Oliv.) Harms, Glycoside St-C1 and Glycoside St-E2 significantly decreased lipid accumulation and the expressions of PPARγ and C/EBPα. Glycoside St-C1 and Glycoside St-E2 were found to activate AMPK when they regulated PPARγ and C/EBPα. Results confirmed that Glycoside St-C1 and Glycoside St-E2 isolated from the leaves of A. henryi (Oliv.) Harms can inhibit adipogenesis through the AMPK-PPARγ-C/EBPα mechanism. Thus, this study suggests that Glycoside St-C1 and Glycoside St-E2 have a therapeutic effect due to activation of the AMPKα.

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Two triterpeniods from Cyclocarya paliurus (Batal) Iljinsk (Juglandaceae) promote glucose uptake in 3T3-L1 adipocytes: The relationship to AMPK activation

Cited by 52 publications

References 34 publications

Metformin and resveratrol ameliorate muscle insulin resistance through preventing lipolysis and inflammation in hypoxic adipose tissue

Metformin and resveratrol ameliorate muscle insulin resistance through preventing lipolysis and inflammation in hypoxic adipose tissue

Cyclocarya paliurus (Batal.) Ijinskaja Aqueous Extract (CPAE) Ameliorates Obesity by Improving Insulin Signaling in the Hypothalamus of a Metabolic Syndrome Rat Model

Anti-adipogenic effect of Glycoside St-E2 and Glycoside St-C1 isolated from the leaves of Acanthopanax henryi (Oliv.) Harms in 3T3-L1 cells

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