Two treatment protocols for induction of preterm parturition in ewes—Evaluation of the effects on lung maturation and lamb survival

Zoller, D.; Vassiliadis, P.M.; Voigt, K.; Sauter‐Louis, Carola; Zerbe, Holm

doi:10.1016/j.smallrumres.2014.12.015

Cited by 16 publications

(13 citation statements)

References 37 publications

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“…In ewes, IP at the 138th gestation day results in uncomplicated birth and non-premature lambs (18,26,34). Although IP at this gestation time point is not preferred by some authors due to premature birth (1, 30), many studies have investigated the timing of IP before the 138th gestation day (26,40). Therefore, the 138th gestation day was planned for IP in this study, and all parturitions were normal.…”

Section: Discussionmentioning

confidence: 95%

“…Clinical and experimental studies note many methods for IP in ewes (4,21,25). IP with glucocorticoids is a conventional method that imitates the effects of fetal cortisol and contributes to early organ maturation in the fetuses, such as lung development (1,33,40). At the 142nd gestation day, IP with dexamethasone synchronized parturition without dystocia (38).…”

Section: Discussionmentioning

confidence: 99%

“…Induction of parturition (IP) is used to terminate the gestation of ewes with pathological conditions, such as metabolic, traumatic or respiratory diseases. IP also provides well-timed manipulation of the newborn lambs and the ewes during parturition (24,33,34,40). Many hormones and medications are used for IP in ewes, including adrenocorticotropic hormone (ACTH) (8), glucocorticoids, PGF 2α and analogues, 3β-hydroxysteroid dehydrogenase enzyme inhibitors (epostane and trilostane) (24,33), progesterone receptor blockers (21,29), and synthetic PGE 1 analogues (misoprostol) (36).…”

Section: Introductionmentioning

confidence: 99%

“…The hormonal mechanisms of the inductive drugs and their physiological effects in the newborns have been discussed in the literature (3,10,19,20,29,30,34,40); however, the advantages and disadvantages of the IP methods have not been studied thoroughly. Here, we aimed to compare the prolactin and oxytocin levels of ewes induced with different IP methods as well as the IgG levels of the colostrum and the serum IgG levels of lambs fed colostrum.…”

Section: Introductionmentioning

confidence: 99%

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Comparison of the endocrinological and immunological results of different induction of parturition methods in ewes

Salci¹,

Demirbilek²,

Güneş³

et al. 2018

Tierarztl Prax Ausg G

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SummaryObjective: This study aimed to compare different induction of parturition (IP) methods in terms of endocrinological and immunological parameters in ewes and lambs. Materials and methods: A total of 24 ewes and their respective 24 lambs were studied. Groups of six ewes were induced on the 138th day: groups I (control), II (dexamethasone), III (aglepristone) and IV (aglepristone + dexamethasone). Blood samples were taken from the ewes from IP to 2 days postpartum at 12-hour intervals for the prolactin and oxytocin analyses. Colostrum and blood samples were collected from the lambs at 0, 12, 24, 36 and 48 hours for the IgG analysis. The prolactin, oxytocin and IgG levels were measured by ELISA. Results: A significant difference was found in prolactin levels in all groups and in the colostral IgG level in group IV with respect to the sampling time. Additionally, a significant difference in prolactin level was found at 24 hours postpartum between group IV and groups I and III. A significant difference in the colostral IgG level was determined at 24 hours after parturition between group III and the other groups and at 48 hours after parturition between groups II and III. A positive and significant correlation between the colostral and serum IgG levels of the lambs was found at 24 hours in groups I and II. Conclusion and clinical relevance: Although varying individual results were found within the groups, the endocrinological and immunological results did not suggest any superiority among the IP methods. Considering the presented study results, a single dose of aglepristone may be used alone or in combination with dexamethasone for IP.

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Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Comparison of the endocrinological and immunological results of different induction of parturition methods in ewes

Salci¹,

Demirbilek²,

Güneş³

et al. 2018

Tierarztl Prax Ausg G

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“…Para cada amostra colhida, preparouse esfregaço sanguíneo corado, para a contagem de 100 células, com corante panótico rápido (LaborClin) para a contagem diferencial de leucócitos (Garcia-navarro, 1994 (Zar, 1998 (Zoller et al, 2015). Essa discrepância pode ser justificada pelos efeitos dos corticosteroides no aparecimento acelerado do surfactante, exercendo influência direta na expansão parcial dos pulmões (Liggins, 1969).…”

Section: Introductionunclassified

Parâmetros hematológicos e perfil bioquímico renal de cordeiros nascidos a termo e prematuros

Feitosa¹,

Alcindo²,

Narciso³

et al. 2017

Arq. Bras. Med. Vet. Zootec.

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 RESUMOO objetivo do presente estudo foi avaliar as variáveis hematológicas e o perfil bioquímico renal sérico de cordeiros nascidos a termo e prematuros do nascimento às 48 horas de vida, bem como verificar a influência da dexametasona sobre tais variáveis. Foram constituídos quatros grupos experimentais: PN (cordeiros nascidos de parto normal, n=15, média de 146 dias); PNDEX (cordeiros nascidos de parto normal cujas mães receberam 16mg de dexametasona aos 141 de gestação, n=8, média de 143 dias); PRE (cordeiros prematuros nascidos de cesarianas aos 138 dias de gestação, n=10) e PREDEX (cordeiros prematuros nascidos de cesarianas aos 138 dias de gestação cujas mães receberam 16mg de dexametasona dois dias antes, n=9). Os valores médios do volume globular e de hemoglobina diminuíram ao longo das 48 horas de observação, nos quatro grupos experimentais, porém dentro dos limites fisiológicos para a espécie. Houve variação da concentração plasmática de proteínas totais em todos os momentos, sendo os menores valores no grupo PRE. A contagem leucocitária foi mais alta no grupo PN apenas no M24h. Ao longo do período, apenas o grupo PN mostrou diferença entre o M24h e os demais momentos, e o grupo PRE apresentou os menores valores de neutrófilos no M0h, M15min e M60min. As concentrações séricas de creatinina foram mais altas no grupo PRE no M60min, M24h e M48h. Em todos os grupos, houve diminuição no M24h e M48h. Os parâmetros avaliados foram afetados pela prematuridade na espécie ovina e a dexametasona teve influência positiva sobre a taxa de sobrevivência dos animais prematuros.Palavras-chave: ovinos, bioquímico, hematologia, prematuros ABSTRACT

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Advances in managing pregnancy toxaemia in sheep

Crilly¹,

Phythian²,

Evans³

2021

In Practice

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Background: Ovine pregnancy toxaemia (OPT) is a metabolic disorder of ewes in late pregnancy. Cases are typically seen in ewes carrying multiple fetuses, hence the alternative name of ‘twin lamb disease’. The disease has been well known for many years. Despite this, the toll inflicted by the disease remains considerable, due both to the poor prognosis of clinically affected animals, even with appropriate treatment, and the impact of the provoking factors of under‐nutrition and concomitant disease on ewe morbidity, lamb survival and flock productivity. Cases of OPT are an indication of shortcomings in the management of late‐pregnancy ewes. Aim of the article: This article provides an update on the aetiopathogenesis, diagnosis, treatment and prevention of OPT, drawing on recently published studies.

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Two treatment protocols for induction of preterm parturition in ewes—Evaluation of the effects on lung maturation and lamb survival

Cited by 16 publications

References 37 publications

Comparison of the endocrinological and immunological results of different induction of parturition methods in ewes

Comparison of the endocrinological and immunological results of different induction of parturition methods in ewes

Parâmetros hematológicos e perfil bioquímico renal de cordeiros nascidos a termo e prematuros

Advances in managing pregnancy toxaemia in sheep

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