Two‐ to four‐year histological follow‐up of gastric mucosa after Helicobacter pylori eradication

Tepeš, Bojan; Kavčič, Boris; Zaletel, Lijana K.; Gubina, Marija; Ihan, Alojz; Poljak, Mario; Križman, Igor

doi:10.1002/(sici)1096-9896(199905)188:1<24::aid-path316>3.3.co;2-6

Cited by 38 publications

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“…Another 4 articles were excluded for the following reasons: all patients had either chronic gastritis or CAG at baseline, incidence of CAG was based on biopsies and not on study participants, incidence of CAG and metaplasia or either of them were grouped together and in one study, no mean follow-up time could be estimated. Due to these exclusions, only 14 studies (from 15 articles) with information on the incidence of CAG could be included in this review [10][11][12][13][14][15][16][17][18][19][20][21][22][23][24]. According to the above described criteria, all of these studies included more than 15 study participants who were diagnosed to be free of CAG at baseline, either by histology ('normal' or 'superficial gastritis') or by serum pepsinogen (PG) levels.…”

Section: Resultsmentioning

confidence: 99%

“…The earliest study was started in 1952 in Finland [15]. The most recent one in 1990-1993 in Slovenia; [19] all studies were published between 1988 and 2008. 2 of the studies were conducted in multiple centres in different countries [20,22].…”

Section: Resultsmentioning

confidence: 99%

“…2 of the studies were conducted in multiple centres in different countries [20,22]. Studies were carried out in Sweden, [10] Columbia, [11] the Netherlands, [12,13] the Netherlands and Sweden, [14] Finland, [15] Estonia, [16,24] Japan, [17,23] USA, [18] Slovenia, [19] Australia, Canada, Germany, and the Netherlands, [20] Germany [21] and Denmark, Finland, Norway and Sweden [22]. Most of the studies were not population-based and consisted of symptomatic patients.…”

Section: Resultsmentioning

confidence: 99%

“…12 studies examined H. pylori infection at baseline by one or more of the following methods: bacterial culture, [12,13,19] histology, [12-16, 18-22, 24] PCR (polymerase chain reaction), [19] rapid urease test, [19] and serology [12-14, 17, 19, 24].…”

Section: Resultsmentioning

confidence: 99%

“…The lowest incidence (0%) was observed in two study populations, one made up of a very special cohort of 71 patients with reflux esophagitis, who were treated by fundoplication (an endoscopic procedure of wrapping the fundus around the esophagus for treatment of reflux esophagitis) and followed for a mean period of 5 years [14]. The other study population consisted of 45 patients who had undergone successful H. pylori eradication therapy before the start of the study [19]. However, there was also a lack of any incident case in subpopulations of 140 H. pylori negative patients who had undergone either fundoplication or who were treated by omeprazole for 7 years and were followed for 7 years [22].…”

Section: Resultsmentioning

confidence: 99%

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Incidence of chronic atrophic gastritis: systematic review and meta-analysis of follow-up studies

et al. 2010

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Chronic atrophic gastritis (CAG) is an important precursor lesion of intestinal gastric cancer. As it is typically asymptomatic, epidemiological data on the incidence of CAG are sparse. We aimed to provide an overview of published data on CAG incidence (overall and according to risk factors) from follow-up studies. Articles with information on incidence of CAG published in English until 26th of July 2009 were identified through a systematic MEDLINE and EMBASE search. Data extracted include study characteristics and key findings regarding the incidence of CAG. A meta-analysis was performed on the association between Helicobacter pylori infection and CAG incidence. Overall, data on CAG incidence were available from 14 studies, in 7 studies incidence could be estimated according to H. pylori infection. Most studies were conducted in symptomatic or high risk populations and the maximum number of incident cases was 284. Incidence estimates ranged from 0 to 11% per year and were consistently below 1% in patients not infected with H. pylori. The highest incidence was observed in a special study conducted on ulcer patients treated by proximal gastric vagotomy. Rate ratios for the association between H. pylori infection and CAG incidence ranged from 2.4 to 7.6 with a summary estimate of 5.0 (95% confidence interval: 3.1-8.3). Incidence of CAG is very low in the absence of H. pylori infection. There is a need for more population-based studies to provide comparable estimates of incidence and the impact of risk factors in the development of CAG.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 3 more Smart Citations

Incidence of chronic atrophic gastritis: systematic review and meta-analysis of follow-up studies

et al. 2010

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The relationship between persistent secretion of RANTES and residual infiltration of eosinophils and memory T lymphocytes afterHelicobacter pylori eradication

et al. 2000

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Helicobacter pylori (HP)-infected gastric mucosa displays a conspicuous infiltration of mononuclear cells as well as neutrophils. RANTES is a potent chemoattractant peptide for memory T lymphocytes and eosinophils. RANTES protein concentration and the numbers of RANTES-, CD45RO-, and major basic protein (MBP)-positive cells were therefore evaluated in the gastric mucosa from 51 patients with HP-positive chronic gastritis before and after HP eradication and from 22 HP-negative healthy volunteers. RANTES protein concentration was significantly elevated in HP-positive cases and remained high after HP eradication. The numbers of RANTES-, CD45RO-, and MBP-positive cells were significantly increased in HP-positive cases and were well correlated with RANTES protein levels. All tended to decrease after HP eradication, but did not reach the level of HP-negative cases, even at 24 months after HP eradication. It was concluded that persistent expression and secretion of RANTES were closely related to residual infiltration of memory T lymphocytes and eosinophils, for a prolonged period after HP eradication. This seems to be an important mechanism of prolonged gastric mucosal immune response against HP infection, even after HP eradication, and of persistent mucosal damage and atrophy.

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Dual effects of Helicobacter pylori vacuolating cytotoxin on human eosinophil apoptosis in early and late periods of stimulation

Kim

Lee

et al. 2010

Eur J Immunol

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Although Helicobacter pylori infections of the gastric mucosa are characterized by the infiltration of inflammatory cells such as eosinophils, the responses of eosinophils to H. pylori vacuolating cytotoxin (VacA) have not been fully elucidated. This study investigates the role of VacA in the apoptosis of human eosinophils. We treated human eosinophils with purified H. pylori VacA and observed that induction of apoptosis is a relatively late event. Expression of cellular inhibitor of apoptosis protein (c-IAP)-2 was upregulated during the early period of VacA stimulation, and transfection with c-IAP2 siRNA augmented apoptotic cell death. VacA caused the translocation of cytoplasmic Bax to the mitochondria and increased cytochrome c release from mitochondria in eosinophils. Transfection of an EoL-1 eosinophil cell line with Bax siRNA decreased the release of cytochrome c and DNA fragmentation. Furthermore, apoptosis facilitated by Bax and cytochrome c was primarily regulated by p38 MAPK in VacA-treated eosinophils. These results suggest that the exposure of human eosinophils to H. pylori VacA induces the early upregulation of c-IAP2 and a relatively late apoptotic response, with the apoptosis progressing through a sequential pathway that includes p38 MAPK activation, Bax translocation, and cytochrome c release.

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Two‐ to four‐year histological follow‐up of gastric mucosa after Helicobacter pylori eradication

Cited by 38 publications

References 0 publications

Incidence of chronic atrophic gastritis: systematic review and meta-analysis of follow-up studies

Incidence of chronic atrophic gastritis: systematic review and meta-analysis of follow-up studies

The relationship between persistent secretion of RANTES and residual infiltration of eosinophils and memory T lymphocytes afterHelicobacter pylori eradication

Dual effects of Helicobacter pylori vacuolating cytotoxin on human eosinophil apoptosis in early and late periods of stimulation

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