Two-step synthesis of vicinal trifluoromethyl primary amines from α-(trifluoromethyl)styrenes and phthalimide

Abstract

A novel two-step synthesis of β-trifluoromethyl containing primary amines from readily available α-(trifluoromethyl)styrenes and phthalimide is developed. The first step involves hydroamination between α-(trifluoromethyl)styrenes and phthalimide (PhthNH) with the assistance...