Two-Stage Reconstruction for Eyelid Deformities in Partial Cryptophthalmos

Lessa, Sergio; Nanci, Marcelo; Sebastiá, Roberto; Flores, Eduardo

doi:10.1097/iop.0b013e318201d627

Cited by 7 publications

(5 citation statements)

References 16 publications

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“…Five cases presented with cryptophthalmos, which was also reported in several articles. 18,19 Although bony clefts were described when the disease was first reported, 1 we only found two cases with bony clefts in our study, indicating that the bony cleft is not a presentation as common as other ocular anomalies.…”

Section: Resultsmentioning

confidence: 50%

Manifestation and grading of ocular involvement in patients with Tessier number 10 clefts

Shao

et al. 2017

Eye

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PurposeThe objective of this study is to evaluate and grade the extent and severity of ocular involvement in Tessier number 10 cleft.Patients and methodsA retrospective, noncomparative, interventional case series was conducted between January 2006 and December 2015. Clinical data were reviewed from 59 patients (85 eyes) with Tessier number 10 clefts. Detailed medical history and ophthalmic examination of patients with a confirmed diagnosis of Tessier number 10 cleft were recorded on an itemized data collection form. Ocular manifestations were categorized as upper eyelid defect, symblepharon with cutaneous pterygium (skin growing onto the globe), corneal complications, and lower eyelid ectropion; components were evaluated and graded on a scale from 0 to 3, according to their severity.ResultsMore than half of the cases (43 eyes, 53.8%) had severe upper eyelid defect, and severe symblepharon with cutaneous pterygium were observed in 38 eyes (47.5%). Nearly half of the cases (40 eyes, 50.0%) have severe corneal complications, and lower eyelid ectropion was found in 34 eyes (42.5%). The severity of symblepharon, corneal complications, and lower eyelid ectropion were significantly correlated with the upper eyelid defect; the correlation coefficient (r) ranged from 0.844 to 0.629 (P<0.0001).ConclusionThis study presents the ocular manifestation of Tessier number 10 clefts with large-series cases, and establishes an effective grading system to evaluate Tessier number 10 clefts, which is useful for the diagnosis, treatment, and prediction of outcomes in patients with a Tessier number 10 cleft.

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Section: Resultsmentioning

confidence: 50%

Manifestation and grading of ocular involvement in patients with Tessier number 10 clefts

Shao

et al. 2017

Eye

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“…4,8 Multiple techniques have been described, including Mustarde-type switch flaps, lower eyelid transposition flaps, modified Cutler-Beard full thickness flaps, preputial skin grafts, oral mucous membrane grafts, hard palate grafts, auricular polytetrafluoroethylene sheets, and amniotic membrane grafts to reconstruct the fornix. [2][3][4][5]8,9 Based on a PubMed search using the terms, "Fraser syndrome," "eyelid reconstruction," and "surgical repair," the authors were unable to find similar cases in the literature. They believe their case represents a novel technique of surgical reconstruction of incomplete cryptophthalmos in a patient with Fraser syndrome.…”

Section: Reconstruction Of Unilateral Incomplete Cryptophthalmos In Fmentioning

confidence: 99%

“…2 There are few reports in the literature detailing surgical approaches to managing the ocular and periocular findings in Fraser syndrome. [3][4][5] The authors present a patient with Fraser syndrome and incomplete cryptophthalmos who underwent combined evisceration with forniceal and eyelid reconstruction using the native scleral remnant. In reporting this case, compliance with Health Insurance Portability and Accountability regulations has been upheld.…”

mentioning

confidence: 99%

Reconstruction of Unilateral Incomplete Cryptophthalmos in Fraser Syndrome

Tran

Lee

Alameddine³

et al. 2017

Ophthalmic Plastic &Amp; Reconstructive Surgery

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A full-term baby girl with Fraser syndrome was born with right incomplete cryptophthalmos. On examination, the globe was completely covered with skin with partially formed eyelids laterally. At 3 years of age, she underwent an evisceration with orbital implant and reconstruction of the eyelids and fornices using the pre-existing scleral remnant. Custom ocular prosthetic fitting was performed 5 weeks postoperatively. At 4 years follow up, she continued to successfully retain an ocular prosthesis.

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“…Surgical steps should include dissection of corneal adhesions from keratinized cornea, mucous membrane graft, Mustarde eyelid switch flap with subsequent division, and further lower lid augmentation as required. Lessa et al, presented in 2011 present a two-stage surgical reconstruction procedure for correction of the upper eyelid and ocular bulb anomalies in cryptophthalmos (Mustardé's technique with fixation of the lower eyelid transposed flap to the levator muscle) 59 .…”

Section: Cryptophtalmosmentioning

confidence: 99%

Fraser syndrome: review of the literature illustrated by a historical adult case

Bouaoud

Olivetto

Testelin

et al. 2020

International Journal of Oral and Maxillofacial Surgery

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Fraser syndrome (cryptophthalmos-syndactyly syndrome) is a rare autosomal recessive malformation disorder. The first description of the syndrome was reported by George Fraser in 1962. The diagnostic is based on major criteria and minor criteria established by van Haelst et al., In 2007. Unilateral or bilateral cryptophthalmos, syndactyly, unilateral renal agenesis and genital anomalies are the most frequent anomalies. Several maxillofacial, oro-dental, ear-nose-throat, hormonal and anorectal disorders are reported. Cardiac malformations, and musculoskeletal anomalies are uncommon. The syndrome id related to mutations in three different genes (FRAS1, FREM2, and GRIP1) resulting in failure of the apoptosis program and disruption of the epithelial-mesenchymal interactions during embryonic development. Prenatal diagnosis is based on detection of renal agenesis and laryngeal atresia together with a family history. Most of the fetuses with severe anomalies are terminated or resulted in stillbirth. All patient or pregnancy with a diagnosis of FS should be referred to expert centers. For the management, a collaborative approach of anesthetists, ENT, maxillofacial surgeons, geneticists is necessary. In vivo and in vitro research models are available to better understand the underlying etiology.

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Two-Stage Reconstruction for Eyelid Deformities in Partial Cryptophthalmos

Cited by 7 publications

References 16 publications

Manifestation and grading of ocular involvement in patients with Tessier number 10 clefts

Manifestation and grading of ocular involvement in patients with Tessier number 10 clefts

Reconstruction of Unilateral Incomplete Cryptophthalmos in Fraser Syndrome

Fraser syndrome: review of the literature illustrated by a historical adult case

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