Two-source interference as the major reason for auditory-threshold estimation error based on DPOAE input–output functions in normal-hearing subjects

Dalhoff, Ernst; Ţurcanu, Diana; Vetešník, Aleš; Gummer, Anthony W.

doi:10.1016/j.heares.2012.12.003

Cited by 21 publications

(39 citation statements)

References 40 publications

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“…Interference causes the fine structure in plots of DPOAE amplitude versus f 2 (Heitmann et al, 1998;Mauermann et al, 1999;Talmadge et al, 1999); that is, these so-called DP-grams contain amplitude maxima and minima at stimulus frequencies of constructive and destructive interference, respectively (Kemp and Brown, 1983;Gaskill and Brown, 1990). The pattern of the DPOAE fine structure was reported to shift along the f 2 -axis with changing primary-tone levels (He and Schmiedt, 1993;Whitehead et al, 1995a), inducing large deviations in the shape and slope of I/O-functions in L 1 ,L 2 space, as also reported later by others (Mauermann and Kollmeier, 2004;Dalhoff et al, 2013). In other words, previously reported primary-tone levels for maximum DPOAE amplitude may have been biased due to wave interference between the two DPOAE components.…”

Section: Introductionsupporting

confidence: 67%

“…The effect of the stimulus and data-processing algorithms on the intensity dependence of DPOAE amplitudes was examined with DPOAE I/O-functions plotted with semilogarithmic axes; that is, with DPOAE amplitude plotted as function of stimulus level, L 2 (Boege and Janssen, 2002;Dalhoff et al, 2013). For both stimulus paradigms, three different types of DPOAE I/O-functions were derived from the L 1 ,L 2 map using stimulus levels based on (1) the L 1 ,L 2 pairs exhibiting the maximum DPOAE amplitude for a given L 2 , determined individually for frequency and subject, (2) the frequency-dependent parameter estimates a f it and b f it (see Table I), independent of subject, and (3) the scissor paradigm (a ¼ 0.4; b ¼ 39 dB) independent of frequency and subject.…”

Section: E Dependence Of Dpoae I/o-functions On Pairs Of Primary-tonmentioning

confidence: 99%

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Level dependence of the nonlinear-distortion component of distortion-product otoacoustic emissions in humans

Zelle

Thiericke

Dalhoff

et al. 2015

The Journal of the Acoustical Society of America

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Distortion-product otoacoustic emissions (DPOAEs) emerge when presenting two primary tones with different frequencies f1 and f2 to the cochlea and are commonly used in diagnosis and research to evaluate the functional state of the cochlea. Optimal primary-tone stimulus levels accounting for the different level dependencies of the traveling-wave amplitudes of the two primary tones near the f2-tonotopic place on the basilar membrane are often used to maximize DPOAE amplitudes. However, parameters defining the optimal levels can be affected by wave interference between the nonlinear-distortion and coherent-reflection components of the DPOAE. Here, the components were separated in the time domain using a pulsed stimulus paradigm and optimal levels determined. Based on the amplitude dependence of the nonlinear-distortion components on primary-tone stimulus levels, level parameters yielding maximum DPOAE amplitudes were derived for six normal-hearing adults and compared to data recorded with continuous two-tone stimulation. The level parameters resulting from analysis of the nonlinear-distortion components show dependence on stimulus frequency and small standard deviations. DPOAE input/output functions derived for optimal levels exhibit larger slopes, wider dynamic range and less variability across subjects than those derived for conventional stimulus and analysis conditions, potentially increasing their reliability and sensitivity for assessing cochlea function.

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Section: Introductionsupporting

confidence: 67%

Section: E Dependence Of Dpoae I/o-functions On Pairs Of Primary-tonmentioning

confidence: 99%

Level dependence of the nonlinear-distortion component of distortion-product otoacoustic emissions in humans

Zelle

Thiericke

Dalhoff

et al. 2015

The Journal of the Acoustical Society of America

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“…Abb. 6a zeigt für Frequenzen von 1,5 bis 6 kHz die Korrelation der EDPT mit den zugehörigen Schwellen der Békésy-Tonaudiometrie [5,26] für 41 Normalhörende und Probanden mit sensorineuraler Schwerhörigkeit. Die Standardabweichung der Schwellenschätzung, σ, beträgt 6,2 dB, der …”

Section: Bedeutung Für Diagnostik Und Screeningunclassified

Objektive Hördiagnostik mit DPOAE

Zelle¹,

Dalhoff²,

Gummer³

2016

HNO

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“…Wave interference between the two components is a major limiting factor when using DPOAEs as an objective and noninvasive measure to evaluate the functional state of the cochlea [4]. Exploiting the different latencies of the components, stimulation with short pulses instead of conventional continuous primary tones enables the separation of the DPOAE components in the time domain [5], which significantly increases the accuracy of DPOAEs when used to estimate behavioral thresholds [4,6].…”

Section: Introductionmentioning

confidence: 99%

“…Exploiting the different latencies of the components, stimulation with short pulses instead of conventional continuous primary tones enables the separation of the DPOAE components in the time domain [5], which significantly increases the accuracy of DPOAEs when used to estimate behavioral thresholds [4,6]. However, there is evidence for additional components in the DPOAE recordings.…”

Section: Introductionmentioning

confidence: 99%

Time-domain analysis of distortion-product otoacoustic emissions using a hydrodynamic cochlea model

Zelle

Dalhoff

Gummer

2017

Current Directions in Biomedical Engineering

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Abstract:As a by-product of nonlinear amplification in the cochlea, the inner ear emits sound waves in response to two tones with different frequencies. These sound waves are measurable in the ear canal as distortion-product otoacoustic emissions (DPOAEs). DPOAEs putatively consist of two components emerging at different locations in the cochlea. Wave interference between the two components limits the accuracy of DPOAEs as a noninvasive measure of cochlear function. Using short stimulus pulses instead of continuous stimuli, the two DPOAE components can be separated in the time domain due to their different latencies. The present work utilizes a nonlinear hydrodynamic cochlea model to simulate short-pulse DPOAEs in the time domain. When adding irregularities to the mechanical parameters of the model, the simulated DPOAE signals show two distinguishable components and long-lasting beat tones, similar to band-pass filtered experimental data from normalhearing human subjects. The model results suggest that the beat tones can occur solely due to interference of the coherent-reflection component with the fading nonlineardistortion component.

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Two-source interference as the major reason for auditory-threshold estimation error based on DPOAE input–output functions in normal-hearing subjects

Cited by 21 publications

References 40 publications

Level dependence of the nonlinear-distortion component of distortion-product otoacoustic emissions in humans

Level dependence of the nonlinear-distortion component of distortion-product otoacoustic emissions in humans

Objektive Hördiagnostik mit DPOAE

Time-domain analysis of distortion-product otoacoustic emissions using a hydrodynamic cochlea model

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