Two sides of the same coin: Insights into the myoepithelial cells in carcinoma ex pleomorphic adenoma development

Scarini, João Figueira; Egal, Érika Said Abu; Lima‐Souza, Reydson Alcides de; Crescencio, Lívia Ramalho; Emerick, Carolina; Kowalski, Luiz Paulo; Altemani, Albina; Mariano, Fernanda Viviane

doi:10.1016/j.critrevonc.2020.103195

Cited by 5 publications

(4 citation statements)

References 49 publications

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“…Tenascin expression is absent in the malignant ductal epithelial cells of the CXPA while a strong and diffuse positivity is present in the cytoplasm of the CXPA malignant myoepithelial cells (69). These findings indicate the importance of tenascin as a contributor to the myoepithelial cell-promoting potential in the CXPA (11). Indeed, a key promoting role of tenascin in the CXPA progression was evidenced in the study by Félix and collaborators (2004) where all cases of CXPA presenting positivity for tenascin showed metastases at some point during the follow-up period (70) (Table 1).…”

Section: Mmps and Timpsmentioning

confidence: 83%

“…The myoepithelial cell in the autophagy/senescence process may produce metabolites that would be used as energy by the epithelial cells. The epithelial cells may break the basement membrane and invade the adjacent tissues ( 96 , 11 ).…”

Section: Ecm In Pa-cxpa Progressionmentioning

confidence: 99%

“…Most of them affect the parotid glands, usually manifesting in adult women between 50 and 70 years old ( 5 , 7 ). Recent studies showed that genomic instability ( 8 , 9 ), metabolic shifts ( 10 ), and changes in the tumor microenvironment (TME), mainly governed by the myoepithelial cell ( 11 ), are the most important molecular events oin the CXPA carcinogenesis.…”

Section: Introductionmentioning

confidence: 99%

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Heterogeneity and versatility of the extracellular matrix during the transition from pleomorphic adenoma to carcinoma ex pleomorphic adenoma: cumulative findings from basic research and new insights

Scarini

Lima‐Souza

Lavareze

et al. 2023

Front. Oral. Health

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Pleomorphic adenoma (PA) is the most common salivary gland tumor, accounting for 50%–60% of these neoplasms. If untreated, 6.2% of PA may undergo malignant transformation to carcinoma ex-pleomorphic adenoma (CXPA). CXPA is a rare and aggressive malignant tumor, whose prevalence represents approximately 3%–6% of all salivary gland tumors. Although the pathogenesis of the PA-CXPA transition remains unclear, CXPA development requires the participation of cellular components and the tumor microenvironment for its progression. The extracellular matrix (ECM) comprises a heterogeneous and versatile network of macromolecules synthesized and secreted by embryonic cells. In the PA-CXPA sequence, ECM is formed by a variety of components including collagen, elastin, fibronectin, laminins, glycosaminoglycans, proteoglycans, and other glycoproteins, mainly secreted by epithelial cells, myoepithelial cells, cancer-associated fibroblasts, immune cells, and endothelial cells. Like in other tumors including breast cancer, ECM changes play an important role in the PA-CXPA sequence. This review summarizes what is currently known about the role of ECM during CXPA development.

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Section: Mmps and Timpsmentioning

confidence: 83%

Section: Ecm In Pa-cxpa Progressionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Heterogeneity and versatility of the extracellular matrix during the transition from pleomorphic adenoma to carcinoma ex pleomorphic adenoma: cumulative findings from basic research and new insights

Scarini

Lima‐Souza

Lavareze

et al. 2023

Front. Oral. Health

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“…Otras funciones incluyen acciones como receptores sensoriales y la producción de componentes de la membrana basal y la matriz extracelular (Rao et al, 2014). Según Figueira Scarini et al (2021) los mioepiteliocitos tienen además un papel supresor tumoral.…”

Section: Discussionunclassified

Carcinoma Mioepitelial Ex-Adenoma Pleomórfico de Glándula Parótida: Reporte de un Caso y Análisis Inmunohistoquímico

Samar-Romani¹,

Avila-Uliarte²,

Corball-de-Santiago³

et al. 2022

Int. J. Odontostomat.

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RESUMEN:El carcinoma mioepitelial es una rara neoplasia maligna de las glándulas salivales; puede originarse de novo o desarrollarse en un adenoma pleomórfico preexistente o un mioepitelioma. Las características histológicas e inmunohistoquímicas de un caso de carcinoma mioepitelial de glándula parótida originado por la transformación maligna de un adenoma pleomórfico primario previo se investigaron en este trabajo. Se demostró la presencia de mitosis, pleomorfismo nuclear, áreas necróticas, mioepiteliocitos con una marcación con p63 superior al 75 % y un índice proliferativo de 15 %, características que pueden desencadenar un desenlace adverso. Resulta clave el examen periódico de la paciente que dará una probabilidad superior de curación y sobrevida y de investigar eventuales recurrencias o metástasis.

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Top Ten Differentials to Mull Over for Head and Neck Myoepithelial Neoplasms

Thompson

2023

Head and Neck Pathol

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Two sides of the same coin: Insights into the myoepithelial cells in carcinoma ex pleomorphic adenoma development

Cited by 5 publications

References 49 publications

Heterogeneity and versatility of the extracellular matrix during the transition from pleomorphic adenoma to carcinoma ex pleomorphic adenoma: cumulative findings from basic research and new insights

Heterogeneity and versatility of the extracellular matrix during the transition from pleomorphic adenoma to carcinoma ex pleomorphic adenoma: cumulative findings from basic research and new insights

Carcinoma Mioepitelial Ex-Adenoma Pleomórfico de Glándula Parótida: Reporte de un Caso y Análisis Inmunohistoquímico

Top Ten Differentials to Mull Over for Head and Neck Myoepithelial Neoplasms

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