Two Separate Episodes of Intramedullary Spinal Cord Metastasis in a Single Patient with Breast Cancer

Choi, Hyun Chul; Yoon, Do Heum; Kim, Seung‐Chul; Cho, Ki Hong; Kim, Sang Hyun

doi:10.3340/jkns.2010.48.2.162

Cited by 15 publications

(9 citation statements)

References 16 publications

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“…In our literature review, we found only one case report about a surgically treated double intramedullary metastasis in patient suffering from breast cancer, but the repetitive lesions occurred separately, each of which as a solitary lesion [36]. In contrast, we reported the treatment of two different intramedullary metastases occurring at the same time.…”

Section: Discussionmentioning

confidence: 94%

“Twins Intramedullary Tumors”: Case Report of a Double Spinal Metastasis from Breast Cancer. Technical Nuances and Review of the Literature

Pizzuti¹,

Ricciardi

Fanfani

et al. 2020

BJSTR

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Intramedullary spinal cord metastases (ISCMs) represent a rare complication of malignancies and have been identified in 0.9-2.1% of all autopsy cases of cancer [1][2][3]. Lung cancer and breast carcinoma represent the majority of primary tumors (59% and 14%, respectively) [4], and the reported incidence is estimated at 0.1-0.4% [4,5]. They become clinically evident in less than 1% of patients suffering from metastatic disease [6,7]. Most of them present with rapid progressive neurological deficits and require immediate evaluation [2,3,6,8,9]. Nowadays, spinal magnetic resonance imaging (MRI) is routinely applied for diagnosis.Surgery aims at decompression of functional neural tissue and histological confirmation of the tumor [9]. Metastatic localization of a malignant disease is usually solitary and at clinical onset the patient has systemic widespread with secondary localization to lung, liver, bones and brain [10]. In this report we describe the case of a 49 year-old woman, affected by breast cancer, we have operated on for two adjacent cervical ISCMs. To our knowledge, this is the first surgical case reported in literature of a double intramedullary metastatic disease, with the two separate lesions occurring simultaneously. The aim of our paper is to describe the clinical features and radiological findings of metastatic intramedullary breast carcinoma, as well as surgical technique with emphasis on intraoperative neurophysiological monitoring (IONM) and a wide literature review about ISCMs from breast cancer.

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Section: Discussionmentioning

confidence: 94%

“Twins Intramedullary Tumors”: Case Report of a Double Spinal Metastasis from Breast Cancer. Technical Nuances and Review of the Literature

Pizzuti¹,

Ricciardi

Fanfani

et al. 2020

BJSTR

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“…These modalities do not pass through the blood-spinal cord barrier. Chemotherapy has no further effect on survival [ 7 , 17 – 19 ].…”

Section: Resultsmentioning

confidence: 99%

“…Some authors have proposed the possibility that chemotherapy for intracerebral metastases can cross the disrupted blood-brain barrier and extrapolated this to ISCMs [ 17 – 19 ]. When compared, the blood-brain barrier and the blood-spinal cord barrier are not entirely identical.…”

Section: Discussionmentioning

confidence: 99%

Current Insights into Surgery for Intramedullary Spinal Cord Metastases: A Literature Review

Kalita

2011

International Journal of Surgical Oncology

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“…Early surgical intervention is necessary for preventing neurological deterioration and improving the quality of life [ 9 ]. Adjuvant radiotherapy should be given especially in cases of partial resection [ 10 ]. In the review article, written by Rostami et al in 2013, the number of MISC cases with the only primary cancer being breast cancer is given as 85.…”

Section: Discussionmentioning

confidence: 99%

Spinal Intramedullary Metastasis of Breast Cancer

Başaran

Tiryaki

Yavuzer

et al. 2014

Case Reports in Medicine

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Objective. Breast cancer accounts for approximately one-third of all cancers in females. Approximately 8.5 % of all central nervous system metastases are located in the spinal cord. These patients have rapidly progressing neurological deficits and require immediate examination. The aim of surgery is decompression of neural tissue and histological evaluation of the tumor. In this paper, we present a case of breast cancer metastasis in thoracic spinal intramedullary area which had been partially excised and then given adjuvant radiotherapy. Case. A 43-year-old female patient with breast cancer for 8 years was admitted to our hospital with complaints of weakness in both legs. Eight years ago, she received chemotherapy and radiotherapy. On her neurological examination, she had paraparesis (left lower extremity: 2/5, right lower extremity: 3/5) and urinary incontinence. Spinal MRI revealed a gadolinium enhancing intramedullary lesion. Pathologic examination of the lesion was consistent with breast carcinoma metastasis. The patient has been taken into radiotherapy. Conclusion. Spinal intramedullary metastasis of breast cancer is an extremely rare situation, but it has a high morbidity and mortality rate. Microsurgical resection is necessary for preservation or amelioration of neurological state and also for increased life expectancy and quality.

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Two Separate Episodes of Intramedullary Spinal Cord Metastasis in a Single Patient with Breast Cancer

Cited by 15 publications

References 16 publications

“Twins Intramedullary Tumors”: Case Report of a Double Spinal Metastasis from Breast Cancer. Technical Nuances and Review of the Literature

“Twins Intramedullary Tumors”: Case Report of a Double Spinal Metastasis from Breast Cancer. Technical Nuances and Review of the Literature

Current Insights into Surgery for Intramedullary Spinal Cord Metastases: A Literature Review

Spinal Intramedullary Metastasis of Breast Cancer

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