Two securinega-type alkaloids from Phyllanthus amarus

Houghton, Peter J.; Woldemariam, Tibebe Z.; O’Shea, Siobhan; Thyagarajan, S P

doi:10.1016/0031-9422(96)00345-7

Cited by 67 publications

(55 citation statements)

References 7 publications

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“…Foo and Wong (1992) have reported the presence of tannin, phyllanthusin D in the plant. Similar reports have reported the occurrence of hypophyllanthin (Mahidol et al, 1994), lignans (Singh et al, 2009) and alkaloids (Houhgton et al, 1996). Venkateswaran et al (1987) have shown that the leaf extract of the plant possess the ability to inhibit hepatitis viruses A and B.…”

Section: Introductionsupporting

confidence: 66%

Antibacterial and antifungal activities of leaf extracts of Phyllanthus amaru Schum and Thonn.

Senjobi¹,

Ettu²,

Otujo³

2017

J. Pharmacognosy Phytother.

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The leaf extracts of Phyllanthus amarus Schum and Thonn. a common Western Nigerian weed, was investigated for phytochemical constituents and antimicrobial activities. Hexane extracts demonstrated the highest extraction of 59% followed by Acetone (57%) and water (48%). Saponins, tannins, alkaloid flavonoids, balsam, anthraquinones and phenols were extracted in an acidic medium. Twelve microorganisms (8 bacterial species and 4 fungal species) were investigated for antimicrobial activities. Generally, the fungal species showed lower minimum inhibitory concentration (MIC) than the bacterial species. The test organisms showed close susceptibility to the leaf extracts when compared with Bacitracin and Erythromycin. Generally, the combination of the leaf extract with either bacitracin or erythromycin alone demonstrated synergistic effect thus showing the potential benefit of combining these standard antibiotics with the leaf extracts of P. amarus for combating infections.

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Section: Introductionsupporting

confidence: 66%

Antibacterial and antifungal activities of leaf extracts of Phyllanthus amaru Schum and Thonn.

Senjobi¹,

Ettu²,

Otujo³

2017

J. Pharmacognosy Phytother.

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“…The wide range of its pharmacological activities was discussed in a number of reviews (Unander et al, 1990(Unander et al, , 1992Bagalkotkar et al, 2006). The extensive phytochemical investigations on several Phyllanthus species revealed various bioactive constituents such as alkaloids, lignans, terpenes, flavones and tannins (Matsunga et al, 1993;Foo, 1995;Bila et al, 1996;Houghton et al, 1996;Lee et al, 1996;Zhang et al, 2001Zhang et al, , 2002Chang et al, 2003). In our continued drug discovery programme from natural Afr.…”

Section: Introductionmentioning

confidence: 99%

Isolation and cytotoxicity of triterpenes from the roots of Phyllanthus pulcher Wall. ex Mll. Arg. (Euphorbiaceae)

Bagalkotkar

Chuan

Khalivulla

et al. 2011

Afr. J. Pharm. Pharmacol.

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The dried powdered roots of Phyllanthus pulcher Wall. ex Müll. Arg. (Euphorbiaceae), were sequentially extracted with dichloromethane (DCM), ethyl acetate (EtOAc) and methanol (MeOH). The extracts were tested for cytotoxic activity against three human cancer cell lines: MCF-7 (breast), NCI-H460 (lung) and DU-145 (prostate). The DCM extract exhibited the strongest cytotoxic activity compared with EtOAc and MeOH extracts. Hence from the DCM extract, five pentacyclic triterpenes, 3α-acetoxyl-25-hydroxyolean-12-en-28-oic acid (1), glochidone (2), 12(13)-dehydro-3α-acetoxyolean-28-oic acid (3), lupanyl acetate (4) and glochidonol (5) were isolated and identified by spectroscopic analyses ( 1 H NMR, C NMR, FT-IR, UV, DEPT, HMQC, HMBC and HREIMS). This is the first report on the isolation of 4 from a natural source, whereas 1 and 3 have already been isolated from the families Hamamelidaceae and Compositae (Asteraceae), respectively. However this is the first study reporting the presence of 1 and 3 in the Euphorbiaceae family. The isolated tritepenes 1-5 were tested against the three human tumour cell lines as stated above. Only compounds 1 and 5 exhibited cytotoxic activity, 5 being most potent with IC 50 values ranging 7.5-13.4 µg/mL (17.1-30.5 µM).

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“…Of which Phyllanthus oligospermus a shrub, is one of the most common species found in Taiwan. 1) Members of Phyllanthus have been reported to produce terpenes, 2,3) alkaloids, 4,5) lignans, [6][7][8] flavonoids, 9,10) and tannins 11,12) with diverse biological activities including inhibition of hepatitis B virus, hypoglycemic, hypotensive and diuretic effects and antinociceptive, antitumor, antioxidant, and antiinflammatory properties. Many species of this genus have long been used in the traditional Chinese medicine for the treatment of eye disease, jaundice, headache, eczema, warts, diarrhea, diabetes, hepatitis and dropsy for liver protection and as diuretic.…”

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confidence: 99%

Cytotoxic Arylnaphthalene Lignans from Phyllanthus oligospermus

2006

CHEMICAL & PHARMACEUTICAL BULLETIN

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Three new arylnaphthalene lignans, namely phyllanthusmins A-C, together with nine known compounds were isolated and characterized from the stems and roots of Phyllanthus oligospermus by a bioassay-guided purification. The structures of the new compounds were elucidated by means of spectroscopic data interpretation. Among them, phyllanthusminA displayed significant cytotoxicity against KB and P-388 cancer cell lines.

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Two securinega-type alkaloids from Phyllanthus amarus

Cited by 67 publications

References 7 publications

Antibacterial and antifungal activities of leaf extracts of Phyllanthus amaru Schum and Thonn.

Antibacterial and antifungal activities of leaf extracts of Phyllanthus amaru Schum and Thonn.

Isolation and cytotoxicity of triterpenes from the roots of Phyllanthus pulcher Wall. ex Mll. Arg. (Euphorbiaceae)

Cytotoxic Arylnaphthalene Lignans from Phyllanthus oligospermus

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