Two Rotavirus Outbreaks Caused by Genotype G2P[4] at Large Retirement Communities

Cardemil, Cristina V.; Cortese, Margaret M.; Medina‐Marino, Andrew; Jasuja, Supriya; Desai, Rishi; Leung, Jessica; Rodriguez‐Hart, Cristina; Villarruel, Gissela; Howland, Julia; Quaye, Osbourne; Tam, Ka Ian; Bowen, Michael D.; Parashar, Umesh D.; Gerber, Susan I.

doi:10.7326/0003-4819-157-9-201211060-00006

Cited by 35 publications

(14 citation statements)

References 46 publications

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“…Although U.S. rotavirus activity has substantially declined since the introduction of rotavirus vaccine, rotavirus disease continues to occur sporadically throughout the year and epidemically in a biennial winter-spring seasonal pattern, affecting even vaccinated persons ( 3 ). Further, as evidenced by these outbreaks as well as previously published reports, rotavirus affects not only young children, but also adults, especially those in congregate living settings ( 5 , 6 ).…”

Section: Discussionsupporting

confidence: 67%

Three Rotavirus Outbreaks in the Postvaccine Era — California, 2017

Burke¹,

Tate²,

Barin³

et al. 2018

MMWR Morb. Mortal. Wkly. Rep.

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Section: Discussionsupporting

confidence: 67%

Three Rotavirus Outbreaks in the Postvaccine Era — California, 2017

Burke¹,

Tate²,

Barin³

et al. 2018

MMWR Morb. Mortal. Wkly. Rep.

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“…Stool samples (n = 91) from surveillance studies and outbreak investigations in the USA and international surveillance studies (Cardemil et al, 2012; Cortes et al, 2012; Gentsch et al, 2009; Hull et al, 2011) were tested in this study. All samples were de-identified and could not be traced back to patient or hospital case identifiers.…”

Section: Methodsmentioning

confidence: 99%

Sensitive and specific nested PCR assay for detection of rotavirus A in samples with a low viral load

Mijatovic-Rustempasic

Esona

Williams

et al. 2016

Journal of Virological Methods

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Techniques such as the real-time reverse transcription-polymerase chain reaction (qRT-PCR) can detect RNA in samples with a low viral load. However, these amplicons typically are either too short or at insufficient concentrations for use in subsequent sequencing reactions for genotyping and detection confirmation. The assay developed in this study detects rotavirus G genotypes and P genotypes with viral loads as low as 6.2 and 8.2 copies per reaction, respectively. The assay was validated using a panel of 91 stool samples, 32 reference rotavirus strains, and 6 non-target enteric virus samples.

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“…Observations of epidemiological data suggest that G2P [4] RVs are particularly adept at causing disease in elderly adults (66)(67)(68). One possible explanation is their reduced immunity to DS-1-like viruses, which have undergone extensive evolution since their childhood and circulated at low frequencies throughout their lifetimes.…”

Section: G2p[4] Vumc Rvs Are Closely Related To Globally Circulating mentioning

confidence: 99%

Molecular Epidemiology of Contemporary G2P[4] Human Rotaviruses Cocirculating in a Single U.S. Community: Footprints of a Globally Transitioning Genotype

McDonald

et al. 2014

J Virol

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Group IMPORTANCELittle is known about the diversity of cocirculating G2 rotaviruses and how their evolution may undermine the effectiveness of rotavirus vaccines. To expand our understanding of the potential genetic range exhibited by rotaviruses circulating in postvaccine communities, we analyzed part of a collection of rotaviruses recovered from pediatric patients in the United States from 2010 to 2011. Examining the genetic makeup of these viruses revealed they represented three segregated groups that did not exchange genetic material. The distinction between these three groups may be explained by three separate introductions. By comparing a specific gene, namely, VP7, of the recent rotavirus isolates to those from a collection recovered from U.S. children between 1974 and 1991 and other globally circulating rotaviruses, we were able to reconstruct the timing of events that shaped their ancestry. This analysis indicates that G2 rotaviruses are continuously evolving, accumulating changes in their genetic material as they infect new patients.

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Two Rotavirus Outbreaks Caused by Genotype G2P[4] at Large Retirement Communities

Abstract: None.

Cited by 35 publications

References 46 publications

Three Rotavirus Outbreaks in the Postvaccine Era — California, 2017

Three Rotavirus Outbreaks in the Postvaccine Era — California, 2017

Sensitive and specific nested PCR assay for detection of rotavirus A in samples with a low viral load

Molecular Epidemiology of Contemporary G2P[4] Human Rotaviruses Cocirculating in a Single U.S. Community: Footprints of a Globally Transitioning Genotype

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