Abstract:Nicotinic acetylcholine receptors (N‐AChRs) mediate fast synaptic signalling and are members of the pentameric ligand‐gated ion channel (pLGIC) family. They rely on a network of accessory proteins in vivo for correct formation and transport to the cell surface. RIC‐3 is an endoplasmic reticulum protein that physically interacts with nascent pLGIC subunits and promotes their oligomerization. It is not known why some N‐AChRs require RIC‐3 in heterologous expression systems, while others do not. Previously we rep… Show more
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