Two rare presentations of embryonal rhabdomyosarcoma of the cervix in teenagers at a low-resource teaching hospital in Ghana: A case series

Bell, Sarah; Konney, Thomas Okpoti; Appiah‐Kubi, Adu; Tawiah, Augustine; Amo‐Antwi, Kwabena; Annan, John Jude Kweku; Lawrence, Emma; Lieberman, Richard W.; Johnston, Carolyn

doi:10.1016/j.gore.2021.100750

Cited by 4 publications

(3 citation statements)

References 15 publications

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“…Most of the current knowledge of RMS comes from case reports, four studies by the Intergroup Rhabdomyosarcoma Study Group (IRSG): IRS-I (1972)(1973)(1974)(1975)(1976)(1977)(1978), IRS-(1978IRS-( -1984, IRS-(1984IRS-( -1991 and IRS-(1991IRS-( -1997)) [1], relevant clinical studies by the International Society of Pediatric Oncology (SIOP) or other organizations, and the expert consensus from the International Soft Tissue Sarcoma Consortium (INSTRuCT) [2]. Only 0.5% of primary RMSs are located in the cervix [3]. Here, we report a case of a minor female with cervical ERMS (cervical sarcoma botryoides) who underwent only biopsy without curative surgery and received nonclassical regimen chemotherapy.…”

Section: Introductionmentioning

confidence: 99%

Successful pregnancy in a female with embryonal rhabdomyosarcoma of the cervix who received biopsy and chemotherapy alone without recurrence after 16 years: a case report and literature review

Qie

Huang

et al. 2023

Preprint

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Background: Embryonal rhabdomyosarcoma (ERMS) of the uterine cervix is rare, but the population affected is mostly underage females. The scope of surgery has now evolved from extensive to limited, and organ-preserving surgery combined with chemotherapy is recommended to preserve the patient's fertility. However, reports of birth outcomes are rare. Case: A minor woman with cervical ERMS who underwent only an outpatient biopsy of the lesion, who had no residual lesion on subsequent multipoint cervical biopsy and who refused radical surgery or cervical conization, after which the patient received a nonclassical regimen of chemotherapy. The patient stopped the chemotherapy on her own, but the patient conceived spontaneously 16 years later with a good pregnancy outcome and no recurrence. Conclusions: This case suggests that preservation of reproductive function is often feasible in immature women with cervical EMS, and the prognosis is usually good as long as the primary tumor can be surgically removed and the lesion is free of residual disease. We also look forward to reports of subsequent growth and pregnancy outcomes in other children with reproductive tract RMS. In cervical ERMS, accurate evaluation of the disease and development of an individualized treatment plan are crucial, and the protection of reproductive function and psychological well-being deserves special attention.

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Section: Introductionmentioning

confidence: 99%

Successful pregnancy in a female with embryonal rhabdomyosarcoma of the cervix who received biopsy and chemotherapy alone without recurrence after 16 years: a case report and literature review

Qie

Huang

et al. 2023

Preprint

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“…Of these, ERMS is the most common type. However, RMS of the uterine cervix is rare, and only 0.5% of primary RMSs are located in the cervix [ 1 ]; thus, the diagnosis and treatment experience of cervical RMS is very short and mainly comes from case reports, four studies by the Intergroup Rhabdomyosarcoma Study Group (IRSG): IRS-I (1972–1978), IRS-I (1978–1984), IRS-II (1984–1991) and IRS-III (1991–1997)) [ 2 ], relevant clinical studies by the International Society of Paediatric Oncology (SIOP) or other organizations, and the expert consensus from the International Soft Tissue Sarcoma Consortium (INSTRuCT) [ 3 ]. Cervical RMS usually occurs in the first two decades of life.…”

Section: Introductionmentioning

confidence: 99%

Successful pregnancy in a female with embryonal rhabdomyosarcoma of the cervix who received biopsy and chemotherapy alone without recurrence after 16 years: a case report and literature review

Yu,

Qie,

Huang

et al. 2023

BMC Women's Health

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Background Embryonal rhabdomyosarcoma (ERMS) of the uterine cervix is rare, but the population affected is mostly underage females. The scope of surgery has now evolved from extensive to limited, and organ-preserving surgery combined with chemotherapy is recommended to preserve the patient’s fertility. However, reports of birth outcomes are rare. Case A minor woman with cervical ERMS who underwent only an outpatient biopsy of the lesion had no residual lesion on subsequent multipoint cervical biopsy and refused radical surgery or cervical conization, after which the patient received a nonclassical regimen of chemotherapy. The patient stopped the chemotherapy on her own, but the patient conceived spontaneously 16 years later with a good pregnancy outcome and no recurrence. Conclusions This case suggests that preservation of reproductive function is often feasible in immature women with cervical ERMS, and the prognosis is usually good as long as the primary tumour can be surgically removed and the lesion is free of residual disease. We also look forward to reports of subsequent growth and pregnancy outcomes in other children with reproductive tract RMS. In cervical ERMS, accurate evaluation of the disease and development of an individualized treatment plan are crucial, and the protection of reproductive function and psychological well-being deserves special attention.

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“…Characteristics and treatment of female patients with botryoid sarcoma[18,25,[27][28][29][30][31][32][33][34][35][36].…”

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confidence: 99%

Sarcoma Botryoides: Optimal Therapeutic Management and Prognosis of an Unfavorable Malignant Neoplasm of Female Children

et al. 2023

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Embryonal rhabdomyosarcoma (ERMS) is a rare malignancy and occurs primarily in the first two decades of life. Botryoid rhabdomyosarcoma is an aggressive subtype of ERMS that often manifests in the genital tract of female infants and children. Due to its rarity, the optimal treatment approach has been a matter of debate. We conducted a search in the PubMed database and supplemented it with a manual search to retrieve additional papers eligible for inclusion. We retrieved 13 case reports and case series, from which we summarized that the current trend is to approach each patient with a personalized treatment plan. This consists of a combination of local debulking surgery and adjuvant or neoadjuvant chemotherapy (NACT). Effort is made in every approach to avoid radiation for the sake of preserving fertility. Radical surgeries and radiation still have a role to play in extensive disease and in cases of relapse. Despite the rarity and aggressiveness of this tumor, disease-free survival and overall prognosis is excellent, especially when it is diagnosed early, compared with other subtypes of rhabdomyosarcoma (RMS). We conclude that the practice of a multidisciplinary approach is appropriate, with favorable outcomes; however, larger-scale studies need to be organized to have a definite consensus on optimal management.

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Two rare presentations of embryonal rhabdomyosarcoma of the cervix in teenagers at a low-resource teaching hospital in Ghana: A case series

Cited by 4 publications

References 15 publications

Successful pregnancy in a female with embryonal rhabdomyosarcoma of the cervix who received biopsy and chemotherapy alone without recurrence after 16 years: a case report and literature review

Successful pregnancy in a female with embryonal rhabdomyosarcoma of the cervix who received biopsy and chemotherapy alone without recurrence after 16 years: a case report and literature review

Successful pregnancy in a female with embryonal rhabdomyosarcoma of the cervix who received biopsy and chemotherapy alone without recurrence after 16 years: a case report and literature review

Sarcoma Botryoides: Optimal Therapeutic Management and Prognosis of an Unfavorable Malignant Neoplasm of Female Children

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