Two Randomized, Double-Blind, Placebo-Controlled Studies Evaluating the S-Caine Peel for Induction of Local Anesthesia Before Long-Pulsed Nd:YAG Laser Therapy for Leg Veins

Abstract

The S-Caine Peel provides safe and highly effective local anesthesia when applied for at least 60 minutes for laser therapy of leg veins. Facile removal of the peel provides a unique advantage and ease in administration.

Review of Lidocaine/Tetracaine Cream as a Topical Anesthetic for Dermatologic Laser Procedures

“…EMLA cream is an emulsion in which the oil phase is a eutectic mixture of 2.5 % lidocaine and 2.5 % prilocaine [1]. Another common topical lidocaine formulation, LMX, uses liposomes as the delivery method for improved penetration and for sustained release of the anesthetic agent (4 % lidocaine) even after the cream is removed from the skin [6, 11].…”

“…One of the benefits of topical local anesthetics is effective anesthesia for certain procedures with little to no systemic exposure to the agent. However, topical anesthetics are often limited by the need for occlusive dressings in order to enhance their epidermal penetration [1, 2]. In addition, inadequate or non-uniform placement of anesthesia over the skin area, messy application, and need for a lengthy application period are other limitations of topical anesthetics [1, 2].…”

“…However, topical anesthetics are often limited by the need for occlusive dressings in order to enhance their epidermal penetration [1, 2]. In addition, inadequate or non-uniform placement of anesthesia over the skin area, messy application, and need for a lengthy application period are other limitations of topical anesthetics [1, 2]. Ideally, topical anesthetics must be able to penetrate the relatively impermeable barrier of the stratum corneum and have minimal systemic absorption [3, 4].…”

“…All local anesthetics except cocaine have vasodilatory effects [7]. An ideal topical anesthetic agent would be easy to apply, show high clinical effectiveness over a short time period, exert its effect on intact skin without systemic effects, and cause nominal pain or discomfort during treatment with minimal to no side effects [1, 3]. There have been many different formulations developed to meet these characteristics [3].…”

Topical Dermatological Drug Delivery: Quo Vadis?

“…The product is initially formulated as a cream and directly applied to the skin in such a form, the cream then undergoes a phase transition to form a flexible film membrane as shown in Fig. (3) on exposure to air after a 20-30 min period [103]. Formulation components include film forming agents (e.g.…”