Two-pot synthesis of N,N-disubstituted 4H-3,1-benzothiazin-2-amines from aryl(2-isothiocyanatophenyl)methanones and secondary amines

NaH-Promoted Transformation of Arylthioureas to Aryl-Isothioureas by S-Allylation and S-Benzylation Reactions

“…For example, exchange reactions of isocyanates, 14 the reaction of aromatic thiols with amines, 15 sodium sulfide as a sulfur source, 16 isocyanates reacting with diazonium salts, 17 but the most widely used method is substituted arylthioureas reacting with primary amines, alkyl halides or benzensulfonic acid. [18][19][20][21][22][23][24] However, these methods suffer from the disadvantages of requiring high temperatures or they give mixtures of products.…”