Two‐pore channel 2 is required for soluble adenylyl cyclase‐dependent regulation of melanosomal pH and melanin synthesis
Dalee Zhou,
Zuhal Eraslan,
Dawson Miller
et al.
Abstract:Melanosomal pH is important for the synthesis of melanin as the rate‐limiting enzyme, tyrosinase, is very pH‐sensitive. The soluble adenylyl cyclase (sAC) signaling pathway was recently identified as a regulator of melanosomal pH in melanocytes; however, the melanosomal proteins critical for sAC‐dependent regulation of melanosomal pH were undefined. We now systematically examine four well‐characterized melanosomal membrane proteins to determine whether any of them are required for sAC‐dependent regulation of m… Show more
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