Two porcine polymorphic microsatellite loci (SO033 and S0035)

Brown, Joy; Archibald, Alan

doi:10.1111/j.1365-2052.1995.tb03256.x

Cited by 8 publications

(10 citation statements)

References 1 publication

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“…We have modified our nomenclature (Rohrer et al 1994b) to reflect the recommendation of the International Society for Animal Genetics (ISAGs) Porcine Genome Mapping Committee (Table 1). Marker CH13 from Rohrer et al (1994b) was subsequently named S0292 (Davies et al 1994) and assigned to chromosome 17 by linkage (Archibald et al 1995). This change agreed with the physical assignments of Alexander et al (1996b) for microsatellites SWR2417, SW2441, SW2427, and SW2431.…”

Section: Discussion Map Development and Integration Of Published Mapssupporting

confidence: 54%

“…This allowed assignment of all previously unassigned linkage groups (Ellegren et al 1994c;Rohrer et al 1994b;Archibald et al 1995), except U1 from Ellegren et al (1994c). Linkage groups for chromosomes 1,2,6,7,8,13, and 16 span the entire length of their GENOME RESEARCH ~ 373 40.…”

Section: Resultsmentioning

confidence: 99%

“…A comparison of marker order between the comprehensive map and those reported by E1-legren et al (1994c) and Archibald et al (1995) revealed only two significant discrepancies. Marker order on chromosomes 3 and 14 were significantly different from the order reported by Archibald et al (1995); however, they were identical to those found by Ellegren et al (1994c).…”

Section: Genome Research @ 381mentioning

confidence: 98%

“…The addition of new markers allowed us to fill in large unmapped intervals and append group H to chromosome 2, group R to chromosome 6, group Z to chromosome 7, SWR68/SW983 to chromosome 9, and group V to chromosome 15 (Rohrer et al 1994b). Also, unassigned 1 (Archibald et al 1995) is on chromosome 8, and U2 (Ellegren et al 1994c) is on chromosome 18.…”

Section: Discussion Map Development and Integration Of Published Mapsmentioning

confidence: 99%

“…Low-resolution genetic maps essential to initial identification of quantitative trait loci (QTL) in livestock have been published for cattle Bishop et al 1994), sheep (Crawford et al 1995), and pigs (Ellegren et al 1994c;Rohrer et al 1994b;Archibald et al 1995). The average interval between markers for these maps ranged from 5.5 cM (Rohrer et al 1994b) to 13.3 cM .…”

mentioning

confidence: 99%

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A comprehensive map of the porcine genome.

Rohrer¹,

Alexander²,

Hu³

et al. 1996

Genome Res.

448

382

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We report the highest density genetic linkage map for a livestock species produced to date. Three published maps for Sus scrofa were merged by genotyping virtually every publicly available microsatellite across a single reference population to yield 1042 linked loci, 536 of which are novel assignments, spanning 2286.2 cM (average interval 2.23 cM) in 19 linkage groups 08 autosomal and X chromosomes, n = 19). Linkage groups were constructed de novo and mapped by locus content to avoid propagation of errors in older genotypes. The physical and genetic maps were integrated with 123 informative loci assigned previously by fluorescence in situ hybridization {FISH). Fourteen linkage groups span the entire length of each chromosome. Coverage of chromosomes 11, 12, 15, and 18 will be evaluated as more markers are physically assigned. Marker-deficient regions were identified only on Ilql.7-qter and 14 cen-ql.2. Recombination rates [cM/Mbp) varied between and within chromosomes. Short chromosomal arms recombined at higher rates than long arms, and recombination was more frequent in telomeric regions than in pericentric regions. The high-resolution comprehensive map has the marker density needed to identify quantitative trait loci [QTL), implement marker-assisted selection or introgression and YAC contig construction or chromosomal microdissection.

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Section: Discussion Map Development and Integration Of Published Mapssupporting

confidence: 54%

Section: Resultsmentioning

confidence: 99%

Section: Genome Research @ 381mentioning

confidence: 98%

Section: Discussion Map Development and Integration Of Published Mapsmentioning

confidence: 99%

mentioning

confidence: 99%

See 3 more Smart Citations

A comprehensive map of the porcine genome.

Rohrer¹,

Alexander²,

Hu³

et al. 1996

Genome Res.

448

382

View full text Add to dashboard Cite

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The PiGMaP consortium linkage map of the pig (Sus scrofa)

Haley²,

et al. 1995

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A linkage map of the porcine genome has been developed by segregation analysis of 239 genetic markers. Eighty-one of these markers correspond to known genes. Linkage groups have been assigned to all 18 autosomes plus the X Chromosome (Chr). As 69 of the markers on the linkage map have also been mapped physically (by others), there is significant integration of linkage and physical map data. Six informative markers failed to show linkage to these maps. As in other species, the genetic map of the heterogametic sex (male) was significantly shorter (approximately 16.5 Morgans) than the genetic map of the homogametic sex (female) (approximately 21.5 Morgans). The sex-averaged genetic map of the pig was estimated to be approximately 18 Morgans in length. Mapping information for 61 Type I loci (genes) enhances the contribution of the pig gene map to comparative gene mapping. Because the linkage map incorporates both highly polymorphic Type II loci, predominantly microsatellites, and Type I loci, it will be useful both for large experiments to map quantitative trait loci and for the subsequent isolation of trait genes following a comparative and candidate gene approach.

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Mapping of quantitative trait loci affecting resistance/susceptibility to Sarcocystis miescheriana in swine

Reiner¹,

Kliemt²,

Willems³

et al. 2007

Genomics

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The outcome of infectious diseases in vertebrates is under genetic control at least to some extent. In swine, e.g., marked differences in resistance/susceptibility to Sarcocystis miescheriana have been shown between Chinese Meishan and European Pietrain pigs, and these differences are associated with high heritabilities. A first step toward the identification of genes and polymorphisms causal for these differences may be the mapping of quantitative trait loci (QTLs). Considering clinical, immunological, and parasitological traits in the above model system, this survey represents the first QTL study on parasite resistance in pigs. QTL mapping was performed in 139 F(2) pigs of a Meishan/Pietrain family infected with S. miescheriana. Fourteen genome-wide significant QTLs were mapped to several chromosomal areas. Among others, major QTLs were identified for bradyzoite numbers in skeletal muscles (F = 17.4; p < 0.001) and for S. miescheriana-specific plasma IgG(2) levels determined 42 days p.i. (F = 20.9; p < 0.001). The QTLs were mapped to different regions of chromosome 7, i.e., to the region of the major histocompatibility complex (bradyzoites) and to an immunoglobulin heavy chain cluster, respectively. These results provide evidence for a direct and causal role for gene variants within these gene clusters (cis-acting) in differences in resistance to S. miescheriana.

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Two porcine polymorphic microsatellite loci (SO033 and S0035)

Cited by 8 publications

References 1 publication

A comprehensive map of the porcine genome.

A comprehensive map of the porcine genome.

The PiGMaP consortium linkage map of the pig (Sus scrofa)

Mapping of quantitative trait loci affecting resistance/susceptibility to Sarcocystis miescheriana in swine

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