Two-pool model with exchange is more sensitive to exchange increases during apoptosis than the partially absorbing wall model

Abstract

Modeling diffusion that incorporates the microscopic partially absorbing wall is a more realistic description compared to the standard Bloch equation based two-site model with exchange. The resulting signal equations are more complex and involve working in the Laplace domain. Here, we demonstrate that the increased spatial relevance of the partially absorbing wall model does not improve fitting in our AML model treated with cisplatin for cell death. In fact, the partially absorbing wall model fits and parameters are poorer. Therefore, extracting diffusion parameters from the Bloch equation based two-site exchange model is sufficient for our diffusion MRI datasets.