Two polysaccharides fromPorphyramodulate immune homeostasis by NF-κB-dependent immunocyte differentiation

Abstract

Porphyra polysaccharides possess multiple pharmacological activities, such as immunoregulatory, anti-tumor and anti-inflammatory effects, but the specific underlying mechanisms are not fully understood.

Establishment of a 3-Dimensional Intestinal Cell Model to Simulate the Intestinal Mucosal Immune System for Food Allergy Investigations

“…On the one hand, these results demonstrated that CMT93 cells, DCs, and T cells were all indispensable for the 3D intestinal cell model for food allergy investigation. On the other hand, the results demonstrated that Th2 rather than Th1 dominated OVA sensitization, which was consistent with previous studies and validated the reliability and specificity of the 3D intestinal cell model in food allergy investigations ( 7 , 26 ).…”

Structural Characterization and Immunostimulatory Activity of Heteropolysaccharides from Fuzhuan Brick Tea

“…A previous experiment proved that macrophages could release NO and a variety of inflammatory cytokines, such as TNF-α, IL-1β, and IL-6, which are directly involved in the activation of the immune system, the inhibition of cancer cells, and the defense against pathogenic microorganisms. , In order to further evaluate the immunomodulatory activity of FBTPS-2-1, the levels of NO and inflammatory cytokines including TNF-α, IL-1β, and IL-6 in RAW264.7 cells were examined. As shown in Figure , LPS, as positive control, could immensely promote the secretion of NO and mRNA expression of iNOS.…”

Immunity boosting roles of biofunctional compounds available in aquafoods: A review

“…Different types of polysaccharides from seaweeds exhibit strong immunomodulatory activity by NF-κB-dependent immunocyte maturation and differentiation. Islam et al., 2013 ; Elaya Perumal and Sundararaj, 2020 ; Fang et al., 2015 ; Fu et al., 2019 ; Sansone et al., 2020 Marine invertebrates Compounds isolated from marine invertebrates possess anticancer, anti-helminthic, antihypertensive, antifungal, antiviral, antibacterial, and immune modulatory properties. Sea cucumber protein hydrolyzate demonstrates not only the reduction of ROS accumulation in cells but also directly scavenge free radicals.…”

“…Polysaccharides from N. rubra have shown immune stimulating effect ( Cheng et al., 2012 ). It has been shown that polysaccharides from red microalga Porphyra exhibited strong immunomodulatory activity by NF-κB-dependent immunocyte maturation and differentiation ( Fu et al., 2019 ).…”