“…Consequently, the related MIMO feedback control design has been and still is an important industrial problem that has been extensively studied with a diversity of linear and nonlinear approaches. Basically, the related two-input (reflux and vapor flow rate via manipulation of the reboiler heat duty) problem design has been studied with several linear and nonlinear control schemes: (i) two composition measurements (DC) [4,6,28], (ii) two point temperature (TPT) schemes [3,5,13], and (iii) cascade composition-to-temperature (DCT) controllers on the basis of one (or two) effluent composition primary measurements in conjunction with one (or two) temperature secondary measurements located in the most sensitive tray per section [2,5,8,25,30]. The DC schemes have the capability of offsetless composition regulation, but yield poor (oscillatory and sluggish) transient response for high-purity columns with measurement dead-times, instrumentation errors as well as feed rate, composition and enthalpy load disturbances.…”