Two-photon excitation studies of m-THPC photosensitizer and photodynamic activity in an epithelial cell line

Dyer, P. E.; Paget, Timothy A.; Snelling, H.V.; Stringer, Maurice

doi:10.1016/j.pdpdt.2006.10.004

Cited by 30 publications

(21 citation statements)

References 14 publications

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“…Since its theoretical prediction by Göppert-Mayer in 1931 [1], the nonlinear optical (NLO) process of two-photon absorption (TPA) has received considerable attention, owing to numerous relevant applications in several fields [2], such as optical limiting [3][4][5], three-dimensional microfabrication [7][8][9][10][11][12][13][14][15], up-converted lasering [16][17][18], photodynamic therapy [19][20][21][22], data storage [23][24][25][26][27][28], and biomedical imaging [29][30][31][32][33].…”

Section: Introductionmentioning

confidence: 99%

Excitonically Coupled Oligomers and Dendrimers for Two-Photon Absorption

Andraud¹,

Fortrie²,

Barsu³

et al. 2008

Advances in Polymer Science

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International audienceThe first part of this review presents the state of the art on two-photon absorbing molecules. Earlyworks concerned the optimization of dipolar push–pull molecules. Recently, the synthesis of linearand branched centrosymmetrical quadrupolar molecules led to higher nonlinearities, but still far from reachingthe fundamental limits of molecular two-photon cross-sections.The second part of this review summarizes our theoretical and experimental results on fluorene-basedoligomers, and branched oligomers (V-shape molecules and dendrimers). They are model molecules to investigatean alternative approach based on spatial assemblies of nonsubstituted π-electronsystems that are coupled by dipole–dipole interactions. In all geometries, two-photon absorptioncross-sections have superlinear dependencies that depend on coupling energies and oligomer sizes. Theseresults are well rationalized by an excitonic model based on N interactingthree-level systems. Analytical expressions for one-photon and two-photon energies and absorption strengthsare derived for linear oligomers. An accurate calculation of large exitonic systems is obtained by diagonalizingthe Hamiltonian operator on a reduced basis set

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Section: Introductionmentioning

confidence: 99%

Excitonically Coupled Oligomers and Dendrimers for Two-Photon Absorption

Andraud¹,

Fortrie²,

Barsu³

et al. 2008

Advances in Polymer Science

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“…2,5,8,11-Tetraoxatridecan-13-yl-4-methylbenzenesulfonate (8), 4-[N,N-bis(2-hydroxyethyl)amino]benzaldehyde (10), 4-(methyl(2,5,8,11-tetraoxatridecan-13-yl)amino)benzaldehyde (15), 4-(di(2,5,8,11-tetraoxatridecan-13-yl)amino)benzaldehyde (16), and 2-(4-(diethylamino)benzylidene)cyclopentanone (18) were synthesized according to our previous reports. 33,36 4-(2,5,8,11,14-Pentaoxahexadecan-16-yl(methyl)amino)-benzaldehyde (9): 3 g of KOH powder and 100 mL of THF were added to a round-bottom bottle.…”

Section: ■ Materials and Methodsmentioning

confidence: 99%

Effective Two-Photon Excited Photodynamic Therapy of Xenograft Tumors Sensitized by Water-Soluble Bis(arylidene)cycloalkanone Photosensitizers

Zou

Zhao

et al. 2015

J. Med. Chem.

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A series of bis(arylidene)cycloalkanone photosensitizers modified by polyethylene glycol (PEG) have been studied for two-photon excited photodynamic therapy (2PE-PDT). As compared with their prototype compounds, these PEGylated photosensitizers show enhanced water solubilities while their photophysical and photochemical properties, including linear absorption, two-photon absorption, fluorescence, and singlet oxygen quantum yield, remain unaltered. In vitro behaviors (cellular uptake, subcellular localization, photocytotoxicity in both PDT and 2PE-PDT) of these photosensitizers reveal that an optimized lipid-water partition coefficient can be obtained by adjusting the length and position of the PEG chains. Among them, the photosensitizer modified asymmetrically by two tetraethylene glycol chains presents the best performance as a 2PE-PDT candidate. Selective blood-vessel closure and obvious therapeutic effect in inhibiting the growth of tumors are confirmed by in vivo 2PE-PDT after intravenous injection of this photosensitiezer. The survival periods of treated tumor-bearing mice are significantly prolonged. This study demonstrates the feasibility of using a simple molecule to construct a potential candidate for 2PE-PDT.

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“…Two-photon PDT (briefly discussed below) promoted the development of femtosecond lasers delivering pulses of light of 800 nm wavelength at 1 kHz frequency (35). Such pulses provide the necessary high peak power (kW-MW) while still maintain low average power that prevents photothermal damage of healthy tissues.…”

Section: New Light Sourcesmentioning

confidence: 99%

Approaches to improve photodynamic therapy of cancer

Firczuk

Winiarska²,

Szokalska³

et al. 2011

Front Biosci

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Photodynamic therapy (PDT) is a clinically approved method of tumor treatment. Its unique mechanism of action results from minimal invasiveness and high selectivity towards transformed cells. However, visible light used to excite most photosensitizers has rather limited ability to penetrate tissues resulting in insufficient destruction of deeply seated malignant cells. Therefore, novel strategies for further potentiation of the anticancer effectiveness of PDT have been developed. These include combined treatments with surgery, chemo- and radiotherapy, strategies targeting cytoprotective mechanisms induced in PDT-treated cells, as well as attempts aimed at enhancement of PDT-mediated antitumor immune response. Moreover, new photosensitizers and novel light sources are being developed. Impressive progress in nanotechnology and understanding of tumor cell biology rise hopes for further improvements in this elegant and promising method of cancer treatment.

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Two-photon excitation studies of m-THPC photosensitizer and photodynamic activity in an epithelial cell line

Cited by 30 publications

References 14 publications

Excitonically Coupled Oligomers and Dendrimers for Two-Photon Absorption

Excitonically Coupled Oligomers and Dendrimers for Two-Photon Absorption

Effective Two-Photon Excited Photodynamic Therapy of Xenograft Tumors Sensitized by Water-Soluble Bis(arylidene)cycloalkanone Photosensitizers

Approaches to improve photodynamic therapy of cancer

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